Multimorbidity is a national and global public health problem that causes a deterioration in people’s health and survival. Health system response is fragmented in several programs with low satisfaction and adherence in patients. Therefore, is advisable to move towards a strategy applying the principles of the Model of Comprehensive Community Health, where the focus ison people, who are activated for their health care. The Ancora Health Innovation Center of the “Universidad Católica” and the Metropolitan Southeast Health Service (SSMSO) carried out a pilot project to implement the Person-Centered Care Model with Multimorbidity (MACEP) aiming to prevent complications and reducing demand at secondary and tertiary care levels. Between 2017 and 2019, 20,642 people were intervened and to evaluate intervention impact they were compared with 32,661 people treated in neighboring not intervened Family Health Care Centers (CESFAM). Significant decreases in the risk of dying and hospitalization were found in the intervened population. Percentage level of MACEP implementation in the seven intervened family health care centers was also evaluated,verifying values from 41 to 100%. The economic evaluation of the pilot project showed higher costs in primary and secondary care, as well as significant savings at the tertiary level, witha net saving in the system total cost. In 2019, the Ministry of Health,drawing on MACEP's experience in the SSMSO, described the Strategy for Person-Centered Comprehensive Care in the Context of Multimorbidity (ECICEP) and began its implementation at the national level. In the case of a public policy that it is still very young,it becomes necessary to deepen the changes that ensure its progress and consolidation.