Evaluation of the in Vitro Immunomodulatory Activity of Lic Extracts of Triplotaxis Stellulifera (Beuth.) Hutch. And Crassocephalum Vitellinum (Benth.) S. Moore

Nfozon, Jinette Ndonkou; Kamtchueng, Monique Odette; Nkwelle, Roland; Orwa, James; Aboge, Gabriel Oluga; Simplice, Moukeu Raymond; Yolande, Feudjio Ndemanou; Boyom, Fabrice Fekam; Tume, Christopher

doi:10.35410/ijaeb.2021.5601

Cited by 1 publication

(2 citation statements)

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“…The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) of the extracts were determined by the broth microdilution Immunomodulatory [20] Tannins [21] A. manniana (Cyatheaceae) 25694/ HNC Leaves, seeds, Stembark Filariasis [22] Backache [23] Antioxidant [24] Flavonoids, quinones, tannins, terpenoids, and steroids [ The antibacterial activity of plant extracts was characterized as bactericidal (MBC/MIC ≤4) or bacteriostatic (MBC/MIC <4) [33]. Additionally, the antifungal activity of plant extracts was considered fungicidal when MFC/MIC ≤4 and fungistatic when MFC/MIC >4 [34].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Phytochemical Screening, Antioxidant, and Antimicrobial Activities of Seven Underinvestigated Medicinal Plants against Microbial Pathogens

Bisso

Nkwelle

Tchuenteu

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Background. Plants are a rich source of therapeutic compounds that have tremendous applications in the pharmaceutical industry. This study aimed to identify the phytochemicals present in the seven selected medicinal plants as well as their antioxidant and antimicrobial activities. Methods. Phytochemical screening, total phenolic, and flavonoid contents were determined using standard methods. The antioxidant activity of plant extracts was determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (OH), and nitric oxide (NO) radical scavenging assays. The antimicrobial activity of the plant extracts was determined by the broth microdilution method. Results. The results of phytochemical analysis showed the presence of phenols, flavonoids, and steroids in all plant extracts. The extract of Psychotria peduncularis showed the highest total phenolic and flavonoid contents (5.57 ± 0.22 mg GAE/g and 1.38 ± 0.06 mg QE/g, respectively). All plant extracts showed very strong antioxidant activity against DPPH and NO radical scavenging with IC50 values ranging from 0.55 to 49.43 µg/mL and 0.65 to 13.7 µg/mL, respectively. The extracts of Tristemma mauritianum and P. peduncularis displayed significant antibacterial activity with MIC values ranging from 16 to 1024 µg/mL. T. mauritianum extract showed bactericidal activity against all tested species. The extracts of Alsophila manianna and P. peduncularis showed significant antifungal activity (MIC = 64 µg/mL) against Candida albicans strain. Conclusion. The screened extracts of medicinal plants used in our study can be used as potential antioxidant and antimicrobial agents, and resources for the development of new drugs.

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Section: Antimicrobial Activitymentioning

confidence: 99%

“…Traditionally, it has been used for the treatment of polyhydramnios and amnionitis affecting newborns. It is also known to have immunomodulatory properties [ 19 , 20 ]. A. manianna synomyn Cyathae manianna is a species of tree fern belonging to the Cyatheaceae family.…”

Section: Introductionmentioning

confidence: 99%