Evaluation of the in vivo biocompatibility of hydroxyapatite granules incorporated with zinc ions

Lima, I.; Alves, Gutemberg Gomes; Fernandes, Gustavo Vicentis de Oliveira; Dias, Eliane Pedra; Soares, Glória Dulce de Almeida; Granjeiro, José Mauro

doi:10.1590/s1516-14392010000400021

Cited by 21 publications

(17 citation statements)

References 24 publications

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“…31 The incorporation of Zn to HA also augmented angiogenic potential which is revealed by the increased number of blood vessels relative to HA alone. 32 In this study, Zn-BGN upregulated the expression of VEGF mRNA in HDPCs and enhanced the formation of the tubular structure of endothelial cells in vitro, suggesting that Zn-BGN has the potential to induce angiogenesis in HDPCs.…”

Section: Discussionsupporting

confidence: 51%

Effects of bioactive cements incorporating zinc-bioglass nanoparticles on odontogenic and angiogenic potential of human dental pulp cells

et al. 2014

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Section: Discussionsupporting

confidence: 51%

Effects of bioactive cements incorporating zinc-bioglass nanoparticles on odontogenic and angiogenic potential of human dental pulp cells

et al. 2014

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“…In addition, foreign ion substitution is also known to enhance osteoconductivity of hydroxyapatite. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] For ion substitution, candidate replacement elements are recommendable to be already present in bone apatite at trace levels due to safety purposes. Thus, sodium, magnesium, potassium, strontium, zinc, barium, copper, aluminum, iron, fluorine, chlorine, and silicon 38,39 can be considered.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, several methods such as variations of sintering temperature, granule size, introductions of porous structures, and electrical polarity have been proposed to improve osteoconductivity of synthetic hydroxyapatite. In addition, foreign ion substitution is also known to enhance osteoconductivity of hydroxyapatite …”

Section: Introductionmentioning

confidence: 99%

Enhanced osteoconductivity of sodium‐substituted hydroxyapatite by system instability

Cho

Yoo

et al. 2013

J Biomed Mater Res

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The effect of substituting sodium for calcium on enhanced osteoconductivity of hydroxyapatite was newly investigated. Sodium-substituted hydroxyapatite was synthesized by reacting calcium hydroxide and phosphoric acid with sodium nitrate followed by sintering. As a control, pure hydroxyapatite was prepared under identical conditions, but without the addition of sodium nitrate. Substitution of calcium with sodium in hydroxyapatite produced the structural vacancies for carbonate ion from phosphate site and hydrogen ion from hydroxide site of hydroxyapatite after sintering. The total system energy of sodium-substituted hydroxyapatite with structural defects calculated by ab initio methods based on quantum mechanics was much higher than that of hydroxyapatite, suggesting that the sodium-substituted hydroxyapatite was energetically less stable compared with hydroxyapatite. Indeed, sodium-substituted hydroxyapatite exhibited higher dissolution behavior of constituent elements of hydroxyapatite in simulated body fluid (SBF) and Tris-buffered deionized water compared with hydroxyapatite, which directly affected low-crystalline hydroxyl-carbonate apatite forming capacity by increasing the degree of apatite supersaturation in SBF. Actually, sodium-substituted hydroxyapatite exhibited markedly improved low-crystalline hydroxyl-carbonate apatite forming capacity in SBF and noticeably higher osteoconductivity 4 weeks after implantation in calvarial defects of New Zealand white rabbits compared with hydroxyapatite. In addition, there were no statistically significant differences between hydroxyapatite and sodium-substituted hydroxyapatite on cytotoxicity as determined by BCA assay. Taken together, these results indicate that sodium-substituted hydroxyapatite with structural defects has promising potential for use as a bone grafting material due to its enhanced osteoconductivity compared with hydroxyapatite.

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“…Zinc ion possibly inhibits the growth of plaque formation and exhibits a promising potential to be used as an antibacterial agent in future dentifrices and mouth rinses [ 6 ]. Zinc containing wound dressings are commonly used for topical applications which enhance healing of chronic and acute wounds [ 7 – 9 ]. Meanwhile, there are also many evidences that zinc can provide anti-infective action in the damaged skin or tissues with little side effects [ 10 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

A novel zinc complex with antibacterial and antioxidant activity

Zhang

et al. 2021

BMC Chemistry

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Background In order to enhance the antibacterial activity and reduce the toxicity of Zn2+, novel complexes of Zn(II) were synthesized. Results A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl2, ZnGC complex presented better antibacterial activity against Staphylococcus aureus (S. aureus, Gram-positive) and Escherichia coli (E. coli, Gram-negative). Conclusions The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.

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Evaluation of the in vivo biocompatibility of hydroxyapatite granules incorporated with zinc ions

Cited by 21 publications

References 24 publications

Effects of bioactive cements incorporating zinc-bioglass nanoparticles on odontogenic and angiogenic potential of human dental pulp cells

Effects of bioactive cements incorporating zinc-bioglass nanoparticles on odontogenic and angiogenic potential of human dental pulp cells

Enhanced osteoconductivity of sodium‐substituted hydroxyapatite by system instability

A novel zinc complex with antibacterial and antioxidant activity

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