Evaluation of the in vivo effects of various laser, light, or ultrasound modalities on human skin treated with a collagen and polymethylmethacrylate microsphere dermal filler product

Wu, Douglas C.; Karnik, Jwala; Margarella, Tara; Nguyen, Vivien; Calame, Antoanella; Goldman, Mitchel P.

doi:10.1002/lsm.22580

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…It is well documented that nonresorbable PMMA microspheres used in facial plastic surgery field, elicit low‐grade foreign body reaction postinjection causing the presence of lymphohistiocytic inflammation and collagen surrounding the PMMA microspheres in human tissue (e.g., abdomen) or dog larynx . which resemble the immunological response invoked by PMMA poly(HIPEs) monoliths in the rats muscle.…”

Section: Resultsmentioning

confidence: 99%

Nonaqueous Synthesis of Macroporous Nanocomposites Using High Internal Phase Emulsion Stabilized by Nanohydroxyapatite

Carranza

Romero-Perez

Almanza-Reyes

et al. 2017

Adv Materials Inter

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Nonaqueous high internal phase emulsions (HIPEs) stabilized by nanohydroxyapatite (NHA)/surfactant hybrids are used as template to prepare interconnected porous monoliths. The use of a sustainable deep eutectic solvent (DES) comprised of urea and choline chloride (UChCl), as the internal phase, enables an efficient interaction of NHA/surfactant at the HIPE interface, which in turn allows for a bottom‐up approach to selective interfacial functionalization of poly(HIPE's) voids surface after polymerization of methyl methacrylate continuous phase. UChCl DES is a suitable internal phase for HIPE polymerization thanks to its polarity and viscosity that provides further stabilization of the emulsion precursor. This simple synthetic method produces well‐defined functional poly(methyl methacrylate) (pMMA) scaffolds with tunable mechanical properties and exposed NHA at the inner surface. Based upon a preliminary biocompatibility in vivo test, poly(HIPEs) show enhanced biocompatibility in comparison with sterile gauze. Interestingly, pMMA NHA nanocomposite scaffold remains in the tissue after 90 d allowing little ingrowth of cells while causing a normal foreign‐body reaction in the rats' muscle tissue. Interfacial functionalization of well‐defined interconnected porous monoliths with nanomaterials via DES‐based HIPEs approach is a promising method that encourages further investigation for the synthesis of biodegradable and biocompatible scaffolds nanocomposites for tissue engineering purposes.

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Section: Resultsmentioning

confidence: 99%

Nonaqueous Synthesis of Macroporous Nanocomposites Using High Internal Phase Emulsion Stabilized by Nanohydroxyapatite

Carranza

Romero-Perez

Almanza-Reyes

et al. 2017

Adv Materials Inter

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“…However, there are concerns that laser treatment after filler injection may affect the filler and cause some unwanted effects. Several studies have shown that laser procedures on fillers can be performed safely without causing other tissue reactions and adverse effects [15,20]. In a previous porcine model study, [15] fractional ablative CO 2 and erbium:YAG lasers created dermal injuries that directly contacted pre‐injected HAF, which was apparent in some ablated microchannels; however, filler morphological changes and denaturation were not observed.…”

Section: Discussionmentioning

confidence: 99%

“…The use of injectable dermal fillers is another well-established procedure in the treatment of acne scars [13,14]. Sometimes, a multimodal combination treatment can be performed as a same-day procedure for patient convenience, and several studies have explored the effects of energy-based devices on hyaluronic acid fillers (HAFs) and other soft-tissue fillers [15][16][17][18][19][20]. However, studies specifically examining the histological effects of picosecond-domain lasers on HAFs are lacking.…”

Section: Introductionmentioning

confidence: 99%

Picosecond‐Domain Fractional Laser Treatment Over Hyaluronic Acid Fillers: In Vivo and Clinical Studies

et al. 2020

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Background and Objectives Combined sequential treatments with multiple modalities such as lasers and soft‐tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond‐domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond‐domain fractional laser treatment over hyaluronic acid fillers (HAFs). We aimed to evaluate the in vivo tissue responses to 1064 nm picosecond‐domain fractional neodymium:yttrium‐aluminum‐garnet (Nd:YAG) laser treatments using microlens array (MLA) applied over pre‐injected HAF in rats. In addition, we evaluated the efficacy and safety of this combined same‐day treatment for atrophic acne scars in patients. Study Design/Materials and Methods Sprague–Dawley rats were subjected to 1064 nm picosecond‐domain fractional Nd:YAG laser treatment immediately after HAF dermal injection. Skin specimens were histologically evaluated on days 0, 7, and 21. In a clinical study, 36 patients with acne scars were treated concurrently with 1064 nm MLA‐type picosecond lasers and HAFs. The patients were scheduled to receive two consecutive treatments at 4‐week intervals, with a follow‐up visit at 12 weeks after the final treatment. Acne scar photographs were graded using the Goodman and Baron's qualitative and quantitative scales at baseline and 12 weeks post‐procedure. Results Picosecond‐domain fractional laser treatment immediately after the dermal injection of HAF into rats did not cause any histological changes in the filler or surrounding skin. In a clinical study, treated subjects (n = 36) achieved significant improvement in acne scars and patient satisfaction. No serious adverse events were observed. Conclusions Combined picosecond laser and HAF treatment were proven to be safe and effective based on in vivo and clinical study results. Facial rejuvenation and scar treatment using a picosecond‐domain fractional laser may be performed immediately after HAF injection. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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“…Both injection fillers decreased in volume over time from 4 weeks after filler injection to 24 weeks of evaluation. The volume changes were as follows: Juvéderm VOLUMA, 120 mm 3 ; Juvéderm VOLBELLA and HA-PN 0.5%, 98 mm 3 ; HA-PN 0.1%, 92 mm 3 ; HA-PN 1%, 97 mm 3 (Fig. 5).…”

Section: Comparison Of Durability Between Ha and Ha-pn Complex Fillermentioning

confidence: 92%

“…Dermal fillers can be used in simple and short procedures in surgery and rapid facial rejuvenation. There is growing interest in the use of fillers for tissue enlargement and improvement of skin aesthetic beauty [1][2][3] .…”

mentioning

confidence: 99%

Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler

Kim

Kwon

Lee

et al. 2020

Sci Rep

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HA (Hyaluronic acid) filler, the most commonly used dermal filler, causes several side effects. HA-PN (Hyaluronic acid-Polynucleotide), a new composite filler, has excellent biocompatibility and induces tissue regeneration. In this study, we compare the efficacies and safety profiles of these fillers. The characteristics of HA and HA-PN fillers were compared using scanning electron microscopy and rheometry. No morphological difference was noted between the fillers. However, the latter had higher viscosity and elasticity values. The HA-PN filler induced higher cell migration than the HA filler in a wound healing assay. It was also found to stimulate better collagen synthesis in human and mouse fibroblasts. The HA and HA-PN fillers were injected into SKH1 hairless mice to determine changes in their volume for up to 24 weeks. Increased cell migration and collagen synthesis were observed in mice injected with the HA-PN complex filler. Although the safety and durability of the HA and HA-PN fillers were similar, the latter induced a lower transient receptor potential vanilloid 4 expression and caused less stimulation upon injection. In conclusion, HA-PN complex fillers can stimulate fibroblast growth and facilitate volume growth and skin regeneration.

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Evaluation of the in vivo effects of various laser, light, or ultrasound modalities on human skin treated with a collagen and polymethylmethacrylate microsphere dermal filler product

Abstract: Laser, light, and ultrasound treatments can safely be administered following a PMMA-collagen injection. Lasers Surg. Med. 48:811-819, 2016. © 2016 Wiley Periodicals, Inc.

Cited by 12 publications

References 16 publications

Nonaqueous Synthesis of Macroporous Nanocomposites Using High Internal Phase Emulsion Stabilized by Nanohydroxyapatite

Nonaqueous Synthesis of Macroporous Nanocomposites Using High Internal Phase Emulsion Stabilized by Nanohydroxyapatite

Picosecond‐Domain Fractional Laser Treatment Over Hyaluronic Acid Fillers: In Vivo and Clinical Studies

Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler

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