Evaluation of the Incidence of Chronic Thromboembolic Pulmonary Hypertension 1 Year After First Episode of Acute Pulmonary Embolism: A Cohort Study

Rashidi, Farid; Parvizi, Rezayat; Bilejani, Eisa; Mahmoodian, Babak; Rahimi, Fatemeh Sadat; Koohi, Ata

doi:10.1007/s00408-019-00315-3

Cited by 9 publications

(14 citation statements)

References 29 publications

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“…A total of 22 cohort studies ( 11 – 32 ) with 5,834 acute PE patients were included. The baseline characteristics of the included cohorts were shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The baseline characteristics of the included cohorts were shown in Table 1 . These studies were published between 2004 and 2020, and performed in Italy ( 11 – 13 , 16 , 19 , 28 ), Spain ( 15 ), the Netherlands ( 14 , 17 ), Germany ( 18 , 21 , 23 ), France ( 20 ), Turkey ( 22 ), Czech ( 25 ), Switzerland ( 29 ), China ( 24 , 26 , 27 , 31 ), Thailand ( 30 ), and Iran ( 32 ). Eighteen of the included studies were prospective cohort studies ( 11 – 17 , 20 – 29 , 32 ), while the other four were retrospective ( 18 , 19 , 30 , 31 ).…”

Section: Resultsmentioning

confidence: 99%

“…These studies were published between 2004 and 2020, and performed in Italy ( 11 – 13 , 16 , 19 , 28 ), Spain ( 15 ), the Netherlands ( 14 , 17 ), Germany ( 18 , 21 , 23 ), France ( 20 ), Turkey ( 22 ), Czech ( 25 ), Switzerland ( 29 ), China ( 24 , 26 , 27 , 31 ), Thailand ( 30 ), and Iran ( 32 ). Eighteen of the included studies were prospective cohort studies ( 11 – 17 , 20 – 29 , 32 ), while the other four were retrospective ( 18 , 19 , 30 , 31 ). The numbers of acute PE patients included in each study varied from 43 to 866.…”

Section: Resultsmentioning

confidence: 99%

“…Our study, using a similar pre-defined classification of the patients showed a similar incidence of CTEPH in consecutive acute PE patients. However, eight recently published studies were included in this updated meta-analysis (24,(26)(27)(28)(29)(30)(31)(32), which predominantly included patients with acute PE survivors. By incorporating these data, we found that the incidence of CTEPH in acute PE survivors were higher than that in acute PE survivors without major comorbidity, which was not consistent with the finding of similar incidence in the two group patients in the previous meta-analysis (9).…”

Section: Discussionmentioning

confidence: 99%

“…Although two previous metaanalyses have been published to summarize the incidence of CTEPH in acute PE patients (9,10), only studies published before 2018 were included (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Some recently published trials were not included (28)(29)(30)(31)(32). Moreover, it remains unknown whether patient and study characteristics such as patient ethnicity, study design, or sample size could significantly affect the incidence of CTEPH.…”

Section: Introductionmentioning

confidence: 99%

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Higher Incidence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism in Asians Than in Europeans: A Meta-Analysis

et al. 2021

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Aim: To summarize the incidence of right heart catheter diagnosed chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary embolism (PE) in a meta-analysis.Methods: Cohort studies reporting the incidence of CTEPH after acute PE were identified via search of Medline, Embase, China National Knowledge Infrastructure and WanFang databases.Results: Twenty-two cohort studies with 5,834 acute PE patients were included. Pooled results showed that the overall incidence of CTEPH was 2.82% (95% CI: 2.11–3.53%). Subgroup analyses showed higher incidence of CTEPH in Asians than Europeans (5.08 vs. 1.96%, p = 0.01), in retrospective cohorts than prospective cohorts (4.75 vs. 2.47%, p = 0.02), and in studies with smaller sample size than those with larger sample size (4.57 vs. 1.71%, p < 0.001). Stratified analyses showed previous venous thromboembolic events and unprovoked PE were both significantly associated with increased risk of CTEPH (OR = 2.57 and 2.71, respectively; both p < 0.01).Conclusions: The incidence of CTEPH after acute PE is ~3% and the incidence is higher in Asians than Europeans. Efforts should be made for the early diagnosis and treatment of CTEPH in PE patients, particularly for high-risk population.

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“…A total of 22 cohort studies ( 11 – 32 ) with 5,834 acute PE patients were included. The baseline characteristics of the included cohorts were shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%