Evaluation of the incorporation of essential oils in microemulsions as a promising formulation in the inhibition of tyrosinase

Sá, Adrielly Á. Menezes de; Santos, Edmilson Willian Propheta dos; Santana, Matheus Henrique Dos Santos; Santos, Adriana de Jesus; Cavalcanti, Sócrates Cabral de Holanda; Santana, Danielle Gomes; Arguelho, Maria De Lara Palmeira de Macedo; Silva, Ana Mara de O. e; Corrêa, Cristiane Bani; Nunes, Rogéria de Souza; Sarmento, Víctor Hugo Vitorino; Lira, Ana Amélia Moreira

doi:10.1016/j.indcrop.2020.112654

Cited by 16 publications

(15 citation statements)

References 47 publications

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“…In-depth studies were conducted to assess rheological properties of O/W microemulsions using a mixture of Tween 80/PG (2:1) (10-30%) as a powerful solubilizer for cinnamon essential oil 2-5%. In this case, viscosity parameter depended on the oil phase amount (20-30%) and the addition of the essential oil, and varied between 166.2-969.5 cP [47].…”

Section: Discussionmentioning

confidence: 99%

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Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

et al. 2022

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The present study brings to attention a method to develop salicylic acid-based oil in water (O/W) microemulsions using a tensioactive system based on Tween 80, lecithin, and propylene glycol (PG), enriched with a vegetable oat oil phase and hyaluronic acid. The systems were physically characterized and the Quality by design approach was applied to optimize the attributes of microemulsions using Box–Behnken modeling, combined with response surface methodology. For this purpose, a 33 fractional factorial design was selected. The effect of independent variables namely X1: Tween 80/PG (%), X2: Lecithin (%), X3: Oil phase (%) was analyzed considering their impact upon the internal structure and evaluated parameters chosen as dependent factors: viscosity, mean droplet size, and work of adhesion. A high viscosity, a low droplet size, an adequate wettability—with a reduced mechanical work—and clarity were considered as desirable for the optimal systems. It was found that the optimal microemulsion which complied with the established conditions was based on: Tween 80/PG 40%, lecithin 0.3%, oat oil 2%, salicylic acid 0.5%, hyaluronic acid 1%, and water 56.2%. The response surface methodology was considered an appropriate tool to explain the impact of formulation factors on the physical properties of microemulsions, offering a complex pattern in the assessment of stability and quality attributes for the optimized formulation.

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Section: Discussionmentioning

confidence: 99%

“…et al, the selection of Tween 80/PG in a ratio of 2:1 from 10% up to 30% was highlighted. This mixture was suitable for stabilizing O/W microemulsions with essential oils of 2-5% and an oil phase of 20-30% as potential skin lightening agents [47].…”

Section: Introductionmentioning

confidence: 99%

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

et al. 2022

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“…OEO, TEO, and CLX have been formulated as microemulsions to treat different diseases (14,15,16,17). In this investigation, we propose a canine mouthwash formulation as a microemulsion system.…”

Section: Discussionmentioning

confidence: 99%

“…Once hydrogenated castor oil was selected as an emulsifier agent, a ternary phase diagram was constructed. Ternary phase diagrams offer information about the thermodynamically stable phases of a three-component system under specific conditions (19) and are considered a tool in microemulsion formulations development (14,15,16,17,20). In this case, the EOM was the oil phase, distilled water was the aqueous phase, and the surfactant agent was the hydrogenated castor oil.…”

Section: Discussionmentioning

confidence: 99%

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Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

Redondo

Corrales

Rojas

et al. 2021

Vitae

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Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they are considered potential therapeutic agents. Objectives: The main objective was to formulate and evaluate the antimicrobial activity of a 0.2% chlorhexidine canine mouthwash with essential oils. Methods: Three microemulsion formulations were obtained by constructing a pseudo-ternary phase diagram using the phase titration method. Different surfactant agents were evaluated, and hydrogenated castor oil was selected as the emulsifier agent. The antimicrobial activity of oregano essential oil (Origanum vulgare), thyme essential oil (Thymus vulgaris), and the three formulations were evaluated against Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, and Escherichia coli. Results: Pure thyme and oregano essential oils showed higher antimicrobial activity than a 0,2% chlorhexidine solution. The formulations with essential oils plus chlorhexidine and chlorhexidine alone showed antimicrobial activity. The formulation containing only essential oils did not show antimicrobial activity. Conclusions: A canine mouthwash was formulated with chlorhexidine and thyme and oregano essential oil. Based on the evaluation of antimicrobial activity, two of the proposed formulations could be a therapeutic option to reduce the risk and prevent periodontal disease in canines.

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Essential oil-in-water microemulsions for topical application: structural study, cytotoxic effect and insect repelling activity

Chatzidaki

Demisli

Zingkou

et al. 2022

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Evaluation of the incorporation of essential oils in microemulsions as a promising formulation in the inhibition of tyrosinase

Cited by 16 publications

References 47 publications

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

Essential oil-in-water microemulsions for topical application: structural study, cytotoxic effect and insect repelling activity

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