Evaluation of the Influence of Antiepileptic Therapy on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Children With Epilepsy

Sobaniec, Wojciech; Sołowiej, Elżbieta; Kułak, Wojciech; Boćkowski, Leszek; Śmigielska-Kuzia, Joanna; Artemowicz, Barbara

doi:10.1177/08830738060210070301

Cited by 28 publications

(14 citation statements)

References 25 publications

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“…Similarly, Vidya and Subramanian [32] reported that SVP-treatment was found to increase levels of malondialdhyde and hydroperoxides and decreased levels of enzymatic (superoxide dismutase [SOD], CAT, and glutathione peroxidase [GPx]) and non-enzymatic (glutathione [GSH]) antioxidants in rats. The activities of SOD, GPx, and GSH reductase were insignificantly lower, whereas the malondialdehyde concentration was insignificantly higher in the erythrocytes of children with epilepsy treated with SVP [33]. Zhang et al [34] found that the levels of malondialdehyde in neutrophils of SVP-treated patients were higher while the activities of SOD and CAT were significantly lower than the control and untreated groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of saffron (Crocus sativusL.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

2014

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The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological changes. A significant decrease in seminiferous tubules and their epithelial heights diameters and inhibition of spermatogenesis was recorded. In addition, the number of sperm head abnormalities was increased. Biochemical results revealed an increase in malondialdhyde (MDA) which is lipid peroxidation marker and a significant decrease in the level of serum antioxidant enzyme, catalase (CAT) and reducing antioxidant power (RAP). Animals given SVP and saffron showed an improvement in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by SVP. Moreover, MDA decreased and CAT and RAP increased. It is concluded from the present results that the ameliorative effects of saffron extract against SVP-induced cytogenetic and testicular damage in albino rats may be due to the presence of one or more antioxidant components of saffron.

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Section: Discussionmentioning

confidence: 99%

Effect of saffron (Crocus sativusL.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

2014

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“…Changes in antioxidant defence mechanisms, as a result of epileptic condition itself or the effects of antiepileptic therapy have been studied in humans, but the observed research findings are discordant [ 5 - 7 , 31 - 47 ].…”

Section: Oxidative Stress In Drug-naive Patients With Epilepsymentioning

confidence: 99%

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

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Epilepsy is known as one of the most frequent neurological diseases, characterized by an enduring predisposition to generate epileptic seizures. Oxidative stress is believed to directly participate in pathways leading to neurodegeneration, which serves as the most important propagating factor, leading to the epileptic condition and cognitive decline. Moreover, there is also a growing body of evidence showing the disturbance of antioxidant system balance and consequently increased production of reactive species in patients with epilepsy. A meta-analysis, conducted in the present review confirms an association between epilepsy and increased lipid peroxidation. Furthermore, it was also shown that some of the antiepileptic drugs could potentially be responsible for additionally increased lipid peroxidation. Therefore, it is reasonable to propose that during the epileptic process neuroprotective treatment with antioxidants could lead to less sever structural damages, reduced epileptogenesis and milder cognitive deterioration. To evaluate this hypothesis studies investigating the neuroprotective therapeutic potential of various antioxidants in cells, animal seizure models and patients with epilepsy have been reviewed. Numerous beneficial effects of antioxidants on oxidative stress markers and in some cases also neuroprotective effects were observed in animal seizure models. However, despite these encouraging results, till now only a few antioxidants have been further applied to patients with epilepsy as an add-on therapy. Based on the several positive findings in animal models, a strong need for more carefully planned, randomized, double-blind, cross-over, placebo-controlled clinical trials for the evaluation of antioxidants efficacy in patients with epilepsy is warranted.

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“…Sobaniec et al and Yük-sel et al found lower levels in patients receiving VPA. 44,45 On the other hand, Kürekçi et al 46 and Cengiz et al 47 reported higher levels of GPx in patients treated with VPA. In our study, GPx activity was higher in VPA group compared with control group in lens tissue.…”

Section: Discussionmentioning

confidence: 95%

The effects of vitamin B6 on lens antioxidant system in valproic acid-administered rats

Tunalı

2013

Hum Exp Toxicol

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Valproic acid (VPA, 2-propyl pentanoic acid) is a broad-spectrum antiepileptic drug (AED) and is commonly used in the treatment of bipolar disorders and epilepsy. AEDs are known to result in vascular disturbances. Vitamin B6 (Vit B6) is water soluble vitamin essential for normal growth, development, and metabolism. In this study, we aimed to investigate the protective effects of Vit B6 against VPA-induced lens damage in experimental animals. In this study, male 4-month-old, Sprague-Dawley rats were used. The animals were divided into four groups. Group I was intact control animals. Group II rats were administered with Vit B6 (50 mg/kg/day) for 7 days. Group III rats were administered with only VPA (500 mg/kg/day) for 7 days. Group IV was given VPA + Vit B6 (in a same dose and time). Vit B6 was given to rats by gavage and VPA was given by intraperitoneally. On the 8th day of experiment, all of the animals were fasted overnight and then killed under ether anesthesia. Lens tissues were taken from animals, homogenized in 0.9% saline to make up a 10% homogenate. The homogenates was used for glutathione (GSH), lipid peroxidation (LPO), protein levels, and enzyme analysis. In VPA groups, levels of lens GSH and LPO and activities of glutathione- S-transferase, glutathione peroxidase, glutathione reductase, and aldose reductase were increased, while superoxide dismutase activity was decreased. Treatment with Vit B6 reversed these effects. These results demonstrated that administration of Vit B6 is potentially beneficial agent to reduce the lens damage in VPA toxicity, probably by decreasing oxidative stress.

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Evaluation of the Influence of Antiepileptic Therapy on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Children With Epilepsy

Cited by 28 publications

References 25 publications

Effect of saffron (Crocus sativusL.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

Effect of saffron (Crocus sativusL.) on sodium valporate induced cytogenetic and testicular alterations in albino rats

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

The effects of vitamin B6 on lens antioxidant system in valproic acid-administered rats

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