Evaluation of the insulin jet injector as a potential source of infection

Price, Joan P.; Kruger, Davida F.; Saravolatz, Louis D.; Whitehouse, Fred W.

doi:10.1016/0196-6553(89)90172-7

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…There are five current forms of insulin based on how long it works in our body starting from rapid to long-acting. All five forms are invasive (32), and they are described briefly as follows:…”

Section: Conventional Insulin Forms and Methodsmentioning

confidence: 99%

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Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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Diabetes is one of the major medical problems in the world. The discovery of insulin was a milestone in the history of medical science. This legendary invention has completed 100 years of its journey. Through this 100-year journey, many important events have taken place, and many modifications have been made to make it convenient for commercialization and patient compliance. After the antidiabetic activity of the pancreatic extract was discovered, the bovine and pork insulin came into use. Then, recombinant human insulin was discovered. Now long-acting to rapid-acting insulin forms are available (e.g., insulin pens, insulin pumps, and the like), and different systems are in use to deliver them to the body, but all these insulins are in invasive dosage forms and have some disadvantages, too. As we are using the oral form of most medicines, we prefer the oral form of insulin. Therefore, the concern is now to develop the oral dosage form of insulin. Some proposed oral dosage forms are at different stages of the clinical trial such as classical dosage forms, enzyme inhibitors, unnatural amino acids, nanoparticles, cell-penetrating peptides, and so on. Since the oral forms of insulin create some limitations and confusion, further research is required to solve these problems. Accordingly, the aim of the review was to predict the possibility of developing marketable oral insulin.

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Section: Conventional Insulin Forms and Methodsmentioning

confidence: 99%

“…Once injected, the combination of fastest-acting insulin will start working immediately. It peaks around the same time as each kind of insulin and lasts as long as the longest-acting insulin (e.g., 30% regular and 70% NPH, 50% lispro and 50% lispro protamine, and the like) (32). Different types of insulin are shown in Figure 2.…”

Section: Premixed Insulinmentioning

confidence: 99%

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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“…The jet injector is a needle‐free system using high pressure instead of the needle to deliver the drug molecules through the skin. Insulin absorption is higher than subcutaneous injection but it may cause bruise or pain …”

Section: Strategies To Improve Non‐invasive Insulin Therapymentioning

confidence: 99%

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Taraghdari

Imani

Mohabatpour

2019

Macromolecular Bioscience

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Diabetes mellitus (DM) is the most prevalent non‐contagious disease, which has affected a large number of people all over the world. Among all treatments known to have a positive influence in the control of DM, insulin therapy is the most common and effective one. Nowadays, various methods of insulin delivery are under investigation, which are able to reach a plausible bioavailability with ignorable side effects instead of insulin injection. This article presents a comprehensive review of the insulin therapy approach with a focus on modified methods in insulin delivery strategies and current advances in engineered insulin delivery systems.

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“…The available jet injectors allow a dose range of two to 50 units of insulin and can deliver insulin in half-unit increments. Insulin that is administered by the jet injector method is absorbed rapidly without the risk of subcutaneous infection29. In gestational diabetes, jet injection therapy is associated with less antiinsulin antibody (AIA) production and better postprandial glycemia30.…”

Section: Current Insulin Delivery Systemsmentioning

confidence: 99%

Recent challenges in insulin delivery systems: A review

Al-Tabakha¹,

Arida²

2008

Indian J Pharm Sci

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Relatively, a large percentage of world population is affected by diabetes mellitus, out of which approximately 5-10% with type 1 diabetes while the remaining 90% with type 2. Insulin administration is essential for type 1 patients while it is required at later stage by the patients of type 2. Current insulin delivery systems are available as transdermal injections which may be considered as invasive. Several non-invasive approaches for insulin delivery are being pursued by pharmaceutical companies to reduce the pain, and hypoglycemic incidences associated with injections in order to improve patient compliance. While any new insulin delivery system requires health authorities' approval, to provide long term safety profile and insuring patients' acceptance. The inhalation delivery system Exubera® has already become clinically available in the United States and Europe for patients with diabetes as non-invasive delivery system.

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Evaluation of the insulin jet injector as a potential source of infection

Cited by 9 publications

References 14 publications

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Recent challenges in insulin delivery systems: A review

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