Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions

Fagone, Paolo; Piombino, Eliana; Mangano, Katia; Pasquale, Rocco De; Nicoletti, Ferdinando; Caltabiano, Rosario

doi:10.3390/antiox12071352

Cited by 1 publication

(1 citation statement)

References 54 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also fascinating to report that the transcription factor Nrf2 was significantly augmented for the genes positively associated with HMOX1. The Nrf2-Keap1-HMOX1 path is a cellular defense mechanism playing a vital role in shielding against oxidative stress and inflammation [58]. This pathway is activated in response to diverse stimuli, involving reactive oxygen species (ROS), heavy metals, and xenobiotics.…”

Section: Nrf2 Regulation and Inflammationmentioning

confidence: 99%

A Review of the Potential of Nuclear Factor [Erythroid-Derived 2]-like 2 Activation in Autoimmune Diseases

Ates,

Yılmaz,

Buttari

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

An autoimmune disease is the consequence of the immune system attacking healthy cells, tissues, and organs by mistake instead of protecting them. Inflammation and oxidative stress (OS) are well-recognized processes occurring in association with acute or chronic impairment of cell homeostasis. The transcription factor Nrf2 (nuclear factor [erythroid-derived 2]-like 2) is of major importance as the defense instrument against OS and alters anti-inflammatory activities related to different pathological states. Researchers have described Nrf2 as a significant regulator of innate immunity. Growing indications suggest that the Nrf2 signaling pathway is deregulated in numerous diseases, including autoimmune disorders. The advantageous outcome of the pharmacological activation of Nrf2 is an essential part of Nrf2-based chemoprevention and intervention in other chronic illnesses, such as neurodegeneration, cardiovascular disease, autoimmune diseases, and chronic kidney and liver disease. Nevertheless, a growing number of investigations have indicated that Nrf2 is already elevated in specific cancer and disease steps, suggesting that the pharmacological agents developed to mitigate the potentially destructive or transformative results associated with the protracted activation of Nrf2 should also be evaluated. The activators of Nrf2 have revealed an improvement in the progress of OS-associated diseases, resulting in immunoregulatory and anti-inflammatory activities; by contrast, the depletion of Nrf2 worsens disease progression. These data strengthen the growing attention to the biological properties of Nrf2 and its possible healing power on diseases. The evidence supporting a correlation between Nrf2 signaling and the most common autoimmune diseases is reviewed here. We focus on the aspects related to the possible effect of Nrf2 activation in ameliorating pathologic conditions based on the role of this regulator of antioxidant genes in the control of inflammation and OS, which are processes related to the progression of autoimmune diseases. Finally, the possibility of Nrf2 activation as a new drug development strategy to target pathogenesis is proposed.

show abstract

Section: Nrf2 Regulation and Inflammationmentioning

confidence: 99%