Evaluation of the lamina cribrosa in patients with diabetes mellitus using enhanced depth imaging spectral-domain optical coherence tomography

Akkaya, Serkan; Küçük, Bekir; Doğan, Hatice; Can, Ertuğrul

doi:10.1177/1479164118782091

Cited by 11 publications

(10 citation statements)

References 38 publications

(35 reference statements)

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“…In the current study, some patients had a comparable to or even smaller LCCI in NTG than in contralateral healthy eyes, suggesting that non-IOPrelated factors such as ONH blood supply may play a more significant role in glaucoma development in these eyes. Akkaya et al 54 have reported that diabetic patients had thicker and more anteriorly positioned LC compared to healthy controls. Of the 76 patients included in the present study, nine (11.8%) had diabetes mellitus (DM).…”

Section: Discussionmentioning

confidence: 98%

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

Kim

Lee

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate intereye differences in lamina cribrosa (LC) morphology in normal tension glaucoma (NTG) patients with unilateral damage. METHODS. A total of 152 eyes of 76 treatment-naive NTG patients with unilateral damage from the ongoing Investigating Glaucoma Progression Study were included. Optic nerve heads were scanned using enhanced-depth spectral-domain optical coherence tomography. The magnitude of the LC curve and LC position were assessed by measuring the LC curve index (LCCI) and LC depth (LCD), respectively, at seven locations spaced equidistantly across the vertical optic disc diameter. LCCI and LCD were compared between glaucomatous and fellow healthy eyes. RESULTS. Eyes with NTG had larger average LCCI and LCD than contralateral healthy eyes (for both P < 0.002). The LCCI was greater in the glaucomatous eyes at all seven locations (P < 0.001). Univariate conditional logistic regression analysis showed that higher baseline intraocular pressure (P ¼ 0.010), deeper LCD (P ¼ 0.007), and larger LCCI (P < 0.001) were significantly associated with the presence of glaucoma. In multivariate analysis, only larger LCCI was significantly associated with the presence of glaucoma (P < 0.001). CONCLUSIONS. Glaucomatous eyes have more steeply curved LC than fellow healthy eyes. This finding suggests that LC undergoes significant remodeling in NTG eyes.

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Section: Discussionmentioning

confidence: 98%

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

Kim

Lee

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…These changes have been linked to ischemia as well as the neuroprotective effects of diabetes. [12][13][14][15][16][17] Even in glaucomatous eyes the effect the ONH is different between those with and without DM. 18 OCTA can demonstrate ischemia of the ONH and LC, which can lead to ganglion cell death.…”

Section: Discussionmentioning

confidence: 99%

Lamina cribrosa curvature index: A reliable parameter to screen diabetic patients for glaucoma

İlhan¹,

Tıskaoğlu²,

Baykara

2022

European Journal of Ophthalmology

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Purpose To compare the translaminar pressure difference (TLPD), anterior lamina cribrosa surface depth (ALCSD), lamina cribrosa thickness (LCT), lamina cribrosa curvature index (LCCI) and peripapillary vascular density (pVD) in diabetic and healthy subjects. Methods Two hundred and eighty eyes of 140 patients (79 patients with diabetes mellitus (DM) without diabetic retinopathy (DR) and 61 healthy subjects) were enrolled in this study. Full ophthalmological examination, as well as optical coherence tomography (OCT) and OCT angiography (OCT-A) images, were analyzed. The ALCSD, LCT, LCCI were measured by enhanced depth imaging (EDI) OCT and the pVD by OCT-A. The TLPD values and relationships between TLPD and lamina cribrosa features and pVD were investigated in all subjects. Results The ALCSD and LCT were significantly shallower and thinner in diabetic patients when compared to healthy subjects (p <0.001). There was no significant difference in the LCCI in diabetics 13.717 (5.74–33.91) vs healthy subjects 13.118 (5.53–27.05) (p = 0.181). OCT-A revealed that the pVD in the diabetic group was significantly lower than in the non-diabetic group (p <0.001). TLPD was significantly lower in diabetic patients compared to healthy controls. Conclusion There are early changes in pVD and peripapillary vessel morphology in patients with DM. ALCSD and LCT were shallower and thinner in diabetic patients whereas the LCCI did not differ significantly. LCCI may be more valuable in assessing the lamina cribrosa (LC) of diabetic patients. The TLPD was found to be lower in diabetic patients compared to normal controls.

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“…Structural and histological changes in the lamina cribrosa are investigated in ocular diseases and in some systemic diseases with ocular involvement (15)(16)(17)(18)(19)(20)(21)(22). Particularly, based on the consideration that it plays a role in the pathogenesis in patients with glaucoma, changes in the lamina cribrosa are investigated (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…LCT was lower in patients with retinal vein occlusion as compared with healthy individuals (21). In a study evaluating the lamina cribrosa using OCT, a thicker and more anteriorly positioned lamina cribrosa was demonstrated in patients with diabetes mellitus as compared with healthy controls (22). A study conducted in healthy adults (≥18 years old) reported a positive correlation between LCT and age (23).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Posterior Ocular Structures in Patients with Isolated Iris Coloboma

Akkaya¹

2020

Beyoglu Eye J

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To measure lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD) and subfoveal choroidal thickness (SFCT) by imaging posterior ocular structures in pediatric cases with isolated unilateral iris coloboma and to investigate the differences as compared with healthy contralateral eyes of these cases (fellow eyes) and healthy control eyes. Methods: This cross-sectional, comparative prospective study included seven children (age range, 9-17 years) with unilateral isolated iris coloboma. The healthy contralateral eyes of these cases formed the fellow group. An age-matched (age range 8-17 years) control group (n=9), including children with both eyes having either normal or corrected-to-normal visual acuity, was formed. A detailed ophthalmic examination was performed. The posterior ocular segments were evaluated using spectral domain-optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) technique. Results: The SFCT was 372.0±48.8 µm, 375.3±44.0 µm, and 386.5±71.8 µm, respectively, and the LCD was 362.4±68.3 µm, 354.4±47.1 µm, and 350.7±38.1 µm, respectively, in the coloboma, fellow, and control eyes. There was no difference between the groups regarding SFCT and LCD. The mean LCT was significantly thinner in the coloboma eyes (200.2±9.5 µm) than in the fellow (238.8±26.7 µm; p=0.023) and control eyes (240.0±12.9 µm; p<0.001). The LCT showed no significant correlation with age, axial length or spherical equivalent. Conclusion: Better visual prognosis is expected in isolated iris coloboma. However, detailed examinations using new technologies, such as SD-OCT, may reveal some structural changes. Longitudinal studies are required to understand if a thinner LCT in coloboma eyes is associated with any future problems.

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Evaluation of the lamina cribrosa in patients with diabetes mellitus using enhanced depth imaging spectral-domain optical coherence tomography

Abstract: The results of this study showed that the optical coherence tomography measurement of lamina cribrosa revealed thicker and more anteriorly positioned lamina cribrosa for patients with diabetes mellitus compared with those for healthy controls.

Cited by 11 publications

References 38 publications

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

Lamina cribrosa curvature index: A reliable parameter to screen diabetic patients for glaucoma

Evaluation of Posterior Ocular Structures in Patients with Isolated Iris Coloboma

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