Evaluation of the Liver Cancer Prevention of Anthocyanin Extracts from Mulberry (&amp;lt;i&amp;gt;Morus alba&amp;lt;/i&amp;gt; L.) Variety PR-01

Liao, Sufeng; Liu, Jianghong; Xu, Ming; Zheng, Jingui

doi:10.4236/abb.2018.99030

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…In this study, the hepatic GST and UGT concentrations in the NDEA group was remarkably ( p < 0.001) reduced as compared to the control group, which is consistent with earlier reports (Liao, Liu, Xu, & Zheng, ). Compared with the NDEA group, the hepatic tissue GST and UGT were significantly increased in the NDEA + CFT‐1 group by 63.94% and 57.95%, respectively (Figure c, p < 0.001).…”

Section: Resultssupporting

confidence: 93%

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Liao

Lin

Liu

et al. 2019

Food Science & Nutrition

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Camellia sinensis (L.) O. Kuntze cv. CFT‐1 is an elite tea variety bred by sexual hybridization with a high content of epigallocatechin‐3‐gallate (EGCG) as 134.2 mg/g (which is 2.54‐fold that of the common variety). This study was to evaluate the chemopreventive effects of CFT‐1 green tea infusion (CFT‐1) against N ‐nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis in rats and its mechanisms. The results showed that CFT‐1 had a superior inhibitory effect in NDEA‐initiated hepatocarcinogenesis compared to that of common tea. CFT‐1 significantly reduced the hepatic nodules incidence, size, and number and prevented the hepatic adenoma or hepatocellular carcinoma (HCC) formation. In particular, CFT‐1‐treated animals had the least incidence of HCC (8.33%) followed by common tea treatment (40.00%) and model control rats (87.50%). CFT‐1 treatment significantly ameliorated abnormal liver function enzymes, reduced serum AFP, CEA, TSGF, and TNF‐α levels, inhibited the dickkopf‐related protein‐1 expression, enhanced antioxidant capacity, suppressed the production of livers 8‐hydroxy‐2′‐deoxyguanosine, and regulated hepatic phase I and II xenobiotic‐metabolizing enzymes. Transcriptomic analysis of liver tissue suggested that compared to common tea, administration of CFT‐1 regulated larger gene sets, which were located in several important pathways of antioxidants, inflammatory network, xenobiotic‐metabolizing enzymes, apoptosis, cell proliferation, and metabolism associated with liver tumorigenesis. We identified some genes as potential molecular targets involved in the prevention of CFT‐1 and found that CFT‐1 inhibited inflammation response, proliferation, and accelerated apoptosis by inhibiting NF‐κB and PI3K/Akt pathway. Thus, EGCG‐rich CFT‐1 green tea might be a potential choice for liver cancer prevention/treatment in the future.

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Section: Resultssupporting

confidence: 93%

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Liao

Lin

Liu

et al. 2019

Food Science & Nutrition

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“…Liao et al, found that 150 mg•kg −1 anthocyanins extracted from mulberries reduce the incidence of liver cancer induced by N-nitrosodiethylamine by half. The protective effect of anthocyanin extract against liver cancer is related to a decrease in the expression of the inflammatory mediator COX-2, which, through the NF-κB pathway, induces the expression of antioxidant enzymes and reduces lipid peroxidation [106]. As nutritional supplements, anthocyanins from blueberries can suppress the development of hepatocellular carcinoma by inhibiting invasion, apoptosis, migration, and proliferationrelated pathways [107].…”

Section: Liver Cancermentioning

confidence: 99%

Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

et al. 2021

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Anthocyanins are natural products that give color to plants. As natural plant pigments, anthocyanins also have a series of health-promoting benefits. Many researchers have proved that anthocyanins have therapeutic effects on diseases, such as circulatory, nervous, endocrine, digestive, sensory, urinary and immune systems. Additionally, a large number of studies have reported that anthocyanins have an anticancer effect through a wide range of anti-inflammatory and antioxidant effects. The anti-disease impact and mechanism of anthocyanins are diverse, so they have high research value. This review summarizes the research progress of anthocyanins on the pharmacological agents of different diseases to provide references for subsequent research.

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“…Also, anthocyanins have the potential of modulating signaling pathways that are deregulated in cancers (Kausar et al, 2012). There is evidence that anthocyanin-rich extracts from some plants (e.g., Ribes nigrum and Morus alba) have a chemopreventive effect against HCC induction in animal models (Bishayee et al, 2011;Liao, Liu, Xu, & Zheng, 2018).…”

Section: Introductionmentioning

confidence: 99%

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

Hooshmand

Mahdinezhad

Jamshidi

et al. 2021

Phytotherapy Research

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Morus nigra is a rich source of anthocyanins, phytochemicals that have anticancer effects.This study aimed to investigate the effects of M. nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC). Male Sprague-Dawley rats were assigned into four groups (n = 10): control, DEN, and DEN +100 or 400 mg/kg of MNE. After 4 months, the DEN group showed a significant mortality rate, hepatic lipid peroxidation, dysplastic nodules in the cirrhotic liver, and an increase of blood bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Also, the body weight gain, blood albumin and glucose, liver antioxidant capacity (thiol groups), and some hematological parameters (RBC, hematocrit, hemoglobin, and platelet) were significantly decreased in the DEN group. MNE significantly increased survival, reduced the size of HCC nodules, improved liver oxidant/antioxidant status, and prevented the above-mentioned changes in the blood (except ALP, glucose, and platelet). Quantitative real-time PCR showed that MNE decreased the expression of Wnt4 and β-catenin, while had no significant effect on PI3K, Akt, and PTEN expression.The MNE did not exhibit antiproliferative activity against HepG2 liver cancer cells. In conclusion, MNE exhibits a hepatoprotective effect through inhibiting oxidative stress and Wnt4/β-catenin pathway and therefore prolongs the survival of rats with HCC.

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Evaluation of the Liver Cancer Prevention of Anthocyanin Extracts from Mulberry (<i>Morus alba</i> L.) Variety PR-01

Cited by 15 publications

References 28 publications

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

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