Evaluation of the liver functional changes in modeling the hemodynamic effects of microgravity in bed rest studies

Afonin, B. V.; Sedova, E. A.; Tikhonova, G. A.; Solovieva, A. A.; Валуев, В. А.

doi:10.1134/s0362119716070021

Cited by 1 publication

(1 citation statement)

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“…Hepatocyte proliferation was negatively regulated by miR-223 in rats under tail suspension [33]. In the human body, head-down bed rest studies showed that short-term duration (12 h) led to a decline in metabolic and detoxified capacities because of reduced blood flow passing through the liver [34], while long-term duration (85 days) caused enlarged cross-sectional area and enhanced flow volume in the portal vein [35]. It was also indicated that five-day bed rest induced non-inflammatory shedding of L-selectin into plasma samples from granulocytes [36], serving as a potential regulator in localized hepatic inflammation.…”

Section: Ground-based Studiesmentioning

confidence: 99%

Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction

Shu

Zhang

et al. 2023

IJMS

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Microgravity exposure during spaceflight causes the disordered regulation of liver function, presenting a specialized mechano-biological coupling process. While YAP/TAZ serves as a typical mechanosensitive pathway involved in hepatocyte metabolism, it remains unclear whether and how it is correlated with microgravity-induced liver dysfunction. Here, we discussed liver function alterations induced by spaceflight or simulated effects of microgravity on Earth. The roles of YAP/TAZ serving as a potential bridge in connecting liver metabolism with microgravity were specifically summarized. Existing evidence indicated that YAP/TAZ target gene expressions were affected by mechanotransductive pathways and phase separation, reasonably speculating that microgravity might regulate YAP/TAZ activation by disrupting these pathways via cytoskeletal remodeling or nuclear deformation, or disturbing condensates formation via diffusion limit, and then breaking liver homeostasis.

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