Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial

Andere, Naira Maria Rebelatto Bechara; Santos, Nídia Cristina Castro dos; Araújo, Cássia Fernandes; Mathias, Ingrid Fernandes; Rossato, Amanda; Marco, Andréa Carvalho De; Santamaria, Milton; Jardini, Maria Aparecida Neves; Santamaría, Mauro Pedrine

doi:10.1016/j.pdpdt.2018.09.002

Cited by 33 publications

(44 citation statements)

References 26 publications

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“…The risk of bias assessment for these four studies is shown in Table 3. All four studies were assessed as having a low risk of bias for random sequence generation and blinding of outcome assessors [12][13][14][15][16]. Two studies were assessed as having a low risk of bias for allocation concealment [12,16], whilst this was unclear in two studies [13][14][15].…”

Section: Search Outcome and Screeningmentioning

confidence: 99%

“…All four studies were assessed as having a low risk of bias for random sequence generation and blinding of outcome assessors [12][13][14][15][16]. Two studies were assessed as having a low risk of bias for allocation concealment [12,16], whilst this was unclear in two studies [13][14][15]. Blinding of participants and personnel was assessed as having a low risk of bias in two studies [12,16], high risk in one study [15] and was unclear in the fourth [13,14].…”

Section: Search Outcome and Screeningmentioning

confidence: 99%

“…Two studies were assessed as having a low risk of bias for allocation concealment [12,16], whilst this was unclear in two studies [13][14][15]. Blinding of participants and personnel was assessed as having a low risk of bias in two studies [12,16], high risk in one study [15] and was unclear in the fourth [13,14]. Incomplete data outcome was assessed as having low risk of bias in two studies [12][13][14], high risk in one study [16] and was unclear in the fourth [14].…”

Section: Search Outcome and Screeningmentioning

confidence: 99%

“…Blinding of participants and personnel was assessed as having a low risk of bias in two studies [12,16], high risk in one study [15] and was unclear in the fourth [13,14]. Incomplete data outcome was assessed as having low risk of bias in two studies [12][13][14], high risk in one study [16] and was unclear in the fourth [14]. Selective outcome reporting was assessed as having high risk of bias in two studies [12,15] and was unclear in two studies [13,14,16].…”

Section: Search Outcome and Screeningmentioning

confidence: 99%

“…Incomplete data outcome was assessed as having low risk of bias in two studies [12][13][14], high risk in one study [16] and was unclear in the fourth [14]. Selective outcome reporting was assessed as having high risk of bias in two studies [12,15] and was unclear in two studies [13,14,16]. All four studies were assessed as having a low risk of bias for any other bias.…”

Section: Search Outcome and Screeningmentioning

confidence: 99%

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Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review

et al. 2019

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Periodontal disease can be treated in several ways. This paper reviewed whether antimicrobial photodynamic therapy (aPDT) in addition to scaling and root planing (SRP) produces improved clinical results over systemic antibiotics (ABs) in conjunction with SRP in adults with periodontitis. Studies were searched using the following electronic databases: MEDLINE, the Cochrane Database of Systematic Reviews, and the Web of Science Core Collection up to and including November 2018. Four randomized controlled trials (RCTs) were reviewed to maximise the reliability of the evidence. All participants suffered from either chronic or aggressive periodontitis and each study contained SRP as an adjunct to ABs or aPDT. To determine whether groups showed improvement after treatment, the outcome parameters chosen were probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Despite finding significant improvements in all groups, the differences among groups were not consistently statistically significant. The lack of homogeneity in the results among these studies indicates that it was not possible to determine a conclusion about whether aPDT or AB as an adjunct to SRP provides better improvements in periodontitis as measured by PD, CAL, and BOP. Further studies with more similar study designs are required before firm conclusions can be deduced.

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Section: Search Outcome and Screeningmentioning

confidence: 99%

Section: Search Outcome and Screeningmentioning

confidence: 99%

Section: Search Outcome and Screeningmentioning

confidence: 99%

Section: Search Outcome and Screeningmentioning

confidence: 99%

Section: Search Outcome and Screeningmentioning

confidence: 99%

See 3 more Smart Citations

Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review

et al. 2019

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Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

Jervøe-Storm,

Bunke,

Worthington

et al. 2024

Cochrane Database of Systematic Reviews

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The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

Aghili,

Jahangirnia,

Alam

et al. 2023

J Basic Microbiol

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Several resistance mechanisms are involved in dental caries, including oral biofilms. An accumulation of bacteria on the surface of teeth is called plaque. Periodontitis and gingivitis are caused by dental plaque. In this review article, we aimed to review the studies associated with the application of photodynamic therapy (PDT) to prevent and treat various microbial biofilm‐caused oral diseases in recent decades. There are several studies published in PubMed that have described antimicrobial photodynamic therapy (APDT) effects on microorganisms. Several in vitro and in vivo studies have demonstrated the potential of APDT for treating endodontic, periodontal, and mucosal infections caused by bacteria as biofilms. Reactive oxygen species (ROS) are activated in the presence of oxygen by integrating a nontoxic photosensitizer (PS) with appropriate wavelength visible light. By causing irreversible damage to microorganisms, ROS induces some biological and photochemical events. Testing several wavelengths has been conducted to identify potential PS for APDT. A standard protocol is not yet available, and the current review summarizes findings from dental studies on APDT.

show abstract

Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial

Cited by 33 publications

References 26 publications

Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review

Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

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