“…There is a variety of PAMAM terminal amine group modifications reported till now, like PEG-ylation, acylation, and hydroxyalkylation [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ], which modify not only the basicity of intrinsic nitrogen atoms but also tune surface hydrophilicity vs. hydrophobicity. On the other hand, amine groups are convenient peripheral sites to attach potential ligands like folate or biotin and are responsible for binding a conjugated carrier selectively to cancer cell membranes [ 5 , 8 , 10 , 13 , 14 , 15 , 16 , 17 , 18 ]. Conjugates bearing anticancer drugs, targeting molecules, and surface-modifying substituents may serve as selective and systematically nontoxic anticancer drugs.…”