Evaluation of the long-term results of trabectome surgery

Yıldırım, Yasemin; Kar, Taner; Düzgün, Eyüp; Sağdiç, Sercan Koray; Ayata, Ali; Ünal, Melih

doi:10.1007/s10792-016-0190-y

Cited by 16 publications

(6 citation statements)

References 21 publications

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“…typically stabilises in the mid-teens range. 5,26,27 These results support the consideration of the trabectome anywhere along the arc of disease where IOP in the mid-teens would be acceptable.…”

Section: Discussionmentioning

confidence: 59%

Comprehensive Trabectome Outcomes in Surgery-naive Versus Previously Operated Eyes

Mosaed¹

2018

European Ophthalmic Review

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This study aims to compare the results of trabectome surgery between surgery-naïve eyes and eyes that have previously undergone incisional surgery. Prospective data was collected on the first 20 cases of each new trabectome surgeon. This trabectome dataset was used to create two groups of subjects: surgery-naïve eyes versus eyes with prior incisional surgery. A total of 2,051 eyes were included in the study. These two groups were further broken down into the subtype of glaucoma (primary open angle glaucoma, pigmentary, pseudoexfoliation, uveitic and steroid-induced glaucoma). At 12- and 36-months follow up, success rates, intraocular pressure (IOP) reduction and medication usage were compared between the groups using the Tube versus Trabeculectomy Study criteria for defining success. At 36 months, the IOP of the virgin eyes and the previously operated eyes was 16.3 mmHg versus 15.8 mmHg, respectively. This difference was not statistically significant (p<0.05). Trabectome outcomes are similar in eyes with a history of prior incisional surgery (including failed glaucoma procedures) compared with those that are surgery-naive.

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Section: Discussionmentioning

confidence: 59%

Comprehensive Trabectome Outcomes in Surgery-naive Versus Previously Operated Eyes

Mosaed¹

2018

European Ophthalmic Review

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“…We observed a significant reduction in IOP at 7 postoperative time points (Figure 2). The complete success rate of trabeculo-canalectomy at 1, 3, 6, 12 and 24 months was 92.5%, 86.8%, 94.3%, 92.5% and 90.6% respectively ( Table 2), which showed good therapeutic effects compared with previous literature [10][11][12]. International and domestic studies reported that IOP drop rate of trabeculectomy combined with anti-metabolizing drugs or releasable sutures in PACG patients was 44-70% [13].…”

Section: Discussionmentioning

confidence: 65%

Two-year outcome of Trabeculo-Canalectomy for Chinese Glaucoma Patients

Xie

et al. 2020

Int. J. Med. Sci.

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To evaluate the efficacy of trabeculo-canalectomy in treating glaucoma patients, a retrospective investigation of 53 glaucoma patients (53 eyes) who underwent trabeculo-canalectomy was conducted at the First Affiliated Hospital of Nanjing Medical University, China, from April 2017 to January 2019. Intraocular pressure (IOP), visual acuity, surgical success rates, medications, and complications were monitored at post-operative 1 day, 1 week, 1, 3, 6, 12 and 24 months. Surgical success criteria were defined as 6 mm Hg≤IOP≤21 mmHg with or without additional medications. Our results showed that average IOP was statistically significant between pre-operative visit and each follow-up visit (all P <0.05). The total success rate of trabeculo-canalectomy at 1, 3, 6, 12 and 24 months was 92.5%, 86.8%, 94.3%, 92.5% and 90.6% respectively. After 3 months post-operatively, all patients had no obvious filtering blebs. The main early complications included postoperative hyphema (7.5%), elevated IOP (5.7%) and anterior chamber exudation (3.8%), which were all cured after conservative treatment. No blebitis, shallow anterior chamber, choroidal detachment and endophthalmitis were observed. Logistic regression analysis showed that patients with secondary glaucoma were more likely to undergo surgical failure 24 months post-operatively (P= 0.008). Thus, we conclude that trabeculo-canalectomy is effective and safe for the treatment of glaucoma.

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“…Esfandiari et al (13) also found PEXG to be associated with a higher chance of success. Discrepancies in reports may be related to the differences in follow-up duration, considering that the reports indicating better results for PEXG had shorter follow-up periods (19)(20)(21)(22)(23). Since PEXG is associated with fibrillary protein deposition in the trabeculum, (24) it may have an initially better response to surgical operations bypassing trabecular resistance.…”

Section: Discussionmentioning

confidence: 99%

Long-term clinical results of trabectome surgery in Turkish patients with primary open angle glaucoma and pseudoexfoliative glaucoma

Ün¹

2023

Beyoglu Eye J

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is the only modifiable risk factor to slow down disease progression (1,2). Glaucoma is a challenging disease of the eye necessitating lifelong follow-up and the leading cause of irreversible vision loss worldwide (3). Objectives:The objectives of the study were to analyze the long-term results of trabectome surgery in Turkish patients with primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) and to characterize the risk factors for failure. Methods: This single-center retrospective non-comparative study included 60 eyes of 51 patients diagnosed with POAG and PEXG, who underwent trabectome alone or phacotrabeculectomy (TP) surgery between 2012 and 2016. Surgical success was defined as a 20% decrease in intraocular pressure (IOP) or IOP≤21 mmHg and no further glaucoma surgery. Risk factors for further surgery were analyzed with the Cox proportional hazard ratio (HR) models. The cumulative success analysis was undertaken with the Kaplan-Meier method based on the time to further glaucoma surgery. Results:The mean follow-up period was 59.4±14.3 months. During the follow-up period, 12 eyes required additional glaucoma surgery. The mean pre-operative IOP was 26.9±6.8 mmHg. The mean IOP at the last visit was 18.8±4.7 mmHg (p<0.01). IOP decreased 30.1% from the baseline to the last visit. The average number of antiglaucomatous drug molecules used was 3.4±0.7 (range 1-4) preoperatively and 2.5±1.3 (range 0-4) at the last visit (p<0.01). The risk factors for further surgery requirement were determined as a higher baseline IOP value (HR: 1.11, p=0.03] and the use of a higher number of preoperative antiglaucomatous drug molecules (HR: 2.54, p=0.09). The cumulative probability of success was calculated as 94.6%, 90.1%, 85.7%, 82.1%, and 78.6% at three, 12, 24, 36, and 60 months, respectively. Conclusion:The success rate of trabectome was 67.3% at 59 months. A higher baseline IOP value and the use of a higher number of antiglaucomatous drug molecules were associated with an increased risk of further glaucoma surgery requirement.

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Evaluation of the long-term results of trabectome surgery

Cited by 16 publications

References 21 publications

Comprehensive Trabectome Outcomes in Surgery-naive Versus Previously Operated Eyes

Comprehensive Trabectome Outcomes in Surgery-naive Versus Previously Operated Eyes

Two-year outcome of Trabeculo-Canalectomy for Chinese Glaucoma Patients

Long-term clinical results of trabectome surgery in Turkish patients with primary open angle glaucoma and pseudoexfoliative glaucoma

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