There are many process parameters involved in the deep drawing of TWBs. Each parameter has different effects on the forming quality and intercrosses each other. It is difficult to establish the relationship between the process parameters and forming quality in traditional methods. The TWBs square box part of the same material with different thickness was taking as the research object, and the common defects of the deep drawing forming part was analysed. The forming process was simulated by using finite element software DYNAFORM, considering five factors, including the thickness combination, the friction coefficient, the punch and die corner radius, the three types of variable blank holder force loading method, as well as the intercross between the variable blank holder force loading method and other factors on the forming quality of the TWBs square box part. The orthogonal test was designed to determine the important order of the various factors under different indicators, and the optimal combination of process parameters was determined by combining the AHP and grey system theory. The optimized parameters of square box part were verified by the finite element method and the deep-drawing test. The results show that the thickness distribution is reasonable, the welding seam movement is small, and there is obvious improvement in the forming quality.