Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes

Bambo, M; Güerri, Noemí; Ferrández, Blanca; Cameo, Beatriz; Fuertes, Isabel; Polo, Vicente; García‐Martín, Elena

doi:10.1159/000453318

Cited by 29 publications

(22 citation statements)

References 32 publications

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“…Lee et al [46] evaluated the rates of structural and functional changes among 465 eyes of 338 subjects with different severities of glaucoma and demonstrated that the VFI rates were significantly worse in the more advanced groups ( p < 0.001). Our results are in agreement with the conclusion of Bambo et al [52] that the correlations of central vision (the 4 central VF thresholds) and the VFI on the HFA 24-2 VF test with mGCIPLT were moderate and statistically significant in early-to-severe stages of glaucoma.…”

Section: Discussionsupporting

confidence: 93%

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

et al. 2020

Ophthalmic Res

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Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma. Methods: In this cross-sectional study, 102 eyes from 102 patients with advanced glaucoma (defined as a 24-2 VF mean deviation (MD) of ≤−12 dB) were included. mGCIPLT, cpRNFLT, and ONH parameters (including the rim area, average cup-to-disc [C:D] ratio, and vertical C:D ratio) were measured using Cirrus high-definition OCT, and 24-2 and 10-2 VF sensitivity tests were performed using standard automated perimetry. Pearson correlations and linear models were used to analyze relationships between OCT-derived parameters and VF parameters. Results: The mGCIPLT and rim area were significantly positively correlated with the 24-2 VF MD, 24-2 VF pattern standard deviation, 24-2 VF visual field index, and 10-2 VF MD, but cpRNFLT was not significantly correlated with VF parameters. In addition, the average and vertical C:D ratios were significantly negatively correlated with VF parameters. The mGCIPLT and rim area were significantly positively correlated with the 10-2 VF MD (r ranging between 0.542 and 0.621, p < 0.001), while the average and vertical C:D ratios were significantly negatively correlated with the 10-2 VF MD (r = −0.537, p < 0.001, and r = −0.428, p < 0.001, respectively). Each 1-µm change in the average mGCIPLT was associated with an approximately 0.368-dB change in the 24-2 VF MD and 0.677-dB change in the 10-2 VF MD (R² = 0.268, p < 0.001, and R² = 0.385, p < 0.001, respectively). The 10-2 VF MD showed a significantly stronger association with inferonasal mGCIPLT than did the 24-2 VF MD in advanced glaucoma (p = 0.007). Conclusions: mGCIPLT and ONH parameters were associated with the severity of VF damage and reflected functional damage better than cpRNFLT in advanced glaucoma. Our results suggested that structural measurements of mGCIPLT and ONH parameters and functional measurement of the 10-2 VF may be useful for monitoring progression in advanced glaucoma.

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Section: Discussionsupporting

confidence: 93%

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

et al. 2020

Ophthalmic Res

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“…To identify factors associated with the rate of MD progression, linear regression analysis was adopted using MD slope as the dependent variable ( Table 3 ). Since OCT parameters have been known for their robust associations with VF indices [ 22 , 23 , 24 ], we created two multivariate models: one with OCT parameters (model 1) and the other without OCT parameters (model 2). According to model 1, average RNFLT was the ultimate factor associated with the rate of MD progression.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma

Lee

Park

2021

JCM

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Purpose: To investigate the clinical significance of vessel density (VD) on visual field (VF) progression regarding the severity of glaucoma. Methods: A total of 130 eyes were recruited in this retrospective and longitudinal study. Superficial and deep VDs in circumpapillary and macular regions were measured via ImageJ. The rate of VF progression was defined as the mean deviation (MD) slope (dB/year). Linear regression was used to verify factors affecting deterioration of VF. The eyes with lower superficial VD were further analyzed. Results: Fifty patients with early glaucoma (EG) (MD > −6 dB) and 52 patients with moderate-to-advanced glaucoma (MAG) (MD ≤ −6 dB) were included. A faster progression rate was found in MAG (p = 0.049). Superficial VD was noticeably related to the VF progression rate in total eyes and in MAG (Both Ps ≤ 0.007, respectively). With patients in the lower half of the superficial VD, the VD was significantly associated with the rate of progression (B, 0.049, p = 0.021). This association was independent of the baseline MD and OCT parameters. Conclusion: Decreased superficial VD might conversely affect the progression of glaucoma even in MAG, which suggests superficial VD could be used as a potential marker to foresee the disease progression even in progressed eyes.

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“…A study by Bambo et al . [ 18 ] compared the cp-RNFL and the macular GCIPL in glaucoma patients at different disease stages in a single OCT device (Cirrus HD OCT) and concluded that the inner macular parameters performed as well as cp-RNFL measurements in patients with different stages of glaucoma. However, in this study, the AUC was not calculated, and the discriminating ability of various parameters was evaluated on the basis of the difference in the mean values of the parameters in early, moderate, and advanced glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Discriminating ability of Cirrus and RTVue optical coherence tomography in different stages of glaucoma

Mittal

Dubey

Gandhi

et al. 2018

Indian J Ophthalmol

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Purpose:The aim of this study is to determine which parameter of Cirrus and RTVue optical coherence tomography (OCT) has the highest ability to discriminate between early, moderate, and advanced glaucoma. Simultaneously, to compare the performance of the two OCT devices in terms of their ability to differentiate the three stages of glaucoma. Further, to analyze the macular parameters of both devices and compare them with the conventional retinal nerve fiber layer (RNFL) parameters.Methods:One hundred and twenty eyes (30 healthy and 90 glaucomatous [30 mild, 30 moderate, and 30 advanced glaucoma]) of 65 participants (15 healthy, 50 glaucomatous [15 mild, 15 moderate, and 20 advanced glaucoma]) underwent Cirrus and RTVue OCT scanning on a single visit.Results:Average RNFL thickness and superior RNFL thickness of both the devices and inferior (ganglion cell complex [GCC] of RTVue device best differentiated normals from all stage glaucomatous eyes (P > 0.05). Cirrus average RNFL thickness and superior RNFL thickness performed better than other parameters (P < 0.05) in differentiating early glaucoma from moderate and advanced. In differentiating advanced from early and moderate glaucoma, RTVue average, superior, and inferior RNFL thickness and inferior GCC parameters had the highest discriminating ability (P < 0.05).Conclusion:Overall, average RNFL thickness had the highest ability to distinguish different stages of the disease. No significant difference was found between RTVue and Cirrus OCT device in different severity levels. No significant difference was observed between RNFL and macular parameters in different stages of glaucoma.

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Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes

Cited by 29 publications

References 32 publications

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma

Discriminating ability of Cirrus and RTVue optical coherence tomography in different stages of glaucoma

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