Evaluation of the mechanical properties and biocompatibility of gypsum-containing calcium silicate cements

Hayashi, Yumiyo; Kawaki, Harumi; Hori, Mizuyo; Shintani, Kohei; Hasegawa, Tomoya; Tanaka, Masashi; Kondoh, Nobuo; Yoshida, Takakazu; Kawano, Satoshi; Tamaki, Yukimichi

doi:10.4012/dmj.2020-086

“…Additionally, BD contains calcium carbonate (CaCO 3 ) (filler material) and calcium oxide (CaO) (traces), whereas PRMTA contains calcium sulfate dihydrate (CaSO 4 ·2H 2 O) (filler material) and tricalcium aluminate (Ca 3 Al 2 O 6 ) (traces) [ 125 ]. The reported data suggest that calcium sulfate dihydrate and calcium carbonate help PRMTA and BD, respectively, to be more cytocompatible for hDPSCs [ 126 ]. All of the mentioned reported outcomes corroborate our findings that BD and PRMTA have very similar abilities and both result in similar viability/proliferation and odonto-/osteogenesis outcomes.…”

Section: Resultsmentioning

confidence: 99%

Comparative Biocompatibility and Odonto-/Osteogenesis Effects of Hydraulic Calcium Silicate-Based Cements in Simulated Direct and Indirect Approaches for Regenerative Endodontic Treatments: A Systematic Review

Yousefi-Koma,

Assadian,

Mohaghegh

et al. 2023

JFB

2

0

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Background: Regenerative dentistry is the operation of restoring dental, oral and maxillofacial tissues. Currently, there are no guidelines for the ideal cement/material in regenerative endodontic treatments (RET). Hydraulic calcium silicate-based cements (hCSCs) are currently the material of choice for RET. Objectives: This systematic review was conducted to gather all of the different direct and indirect approaches of using hCSCs in RET in vitro and in vivo, and to ascertain if there are any superiorities to indirect approaches. Methods and Materials: This systematic review was conducted according to the 2020 PRISMA guidelines. The study question according to the PICO format was as follows: Comparison of the biological behavior (O) of stem cells (P) exposed to hCSCs through direct and indirect methods (I) with untreated stem cells (C). An electronic search was executed in Scopus, Google Scholar, and PubMed. Results: A total of 78 studies were included. Studies were published between 2010 and 2022. Twenty-eight commercially available and eighteen modified hCSCs were used. Seven exposure methods (four direct and three indirect contacts) were assessed. ProRoot MTA and Biodentine were the most used hCSCs and had the most desirable results. hCSCs were either freshly mixed or set before application. Most studies allowed hCSCs to set in incubation for 24 h before application, which resulted in the most desirable biological outcomes. Freshly mixed hCSCs had the worst outcomes. Indirect methods had significantly better viability/proliferation and odonto-/osteogenesis outcomes. Conclusion: Biodentine and ProRoot MTA used in indirect exposure methods result in desirable biological outcomes.

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“…Calcium silicate cement containing synthesized gypsum showed minimal cytotoxicity and did not inhibit in human dental pulp stem cells (hDPSC) proliferation [10] . The highest cell viability was demonstrated by Biodentine, MTA and Repair HP, in descending order.…”

Section: Mtamentioning

confidence: 99%

TheraCal as the material of choice for direct pulp treatment compared to two other materials: MTA and biodentine

Dominguez¹,

Martínez²,

Delgado³

et al. 2022

Int. J. Appl. Dent. Sci.

1

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Introduction: Direct pulp treatment is a procedure in which the exposed vital pulp is treated with a therapeutic material, it is sought to promote healing, maintain pulp vitality and protect the pulp. Objective: To prove that TheraCal is the material of choice as a coating for direct pulp treatment in terms of biocompatibility and cytotoxicity, solubility and clinical management, effects on the pulp, clinical and radiographic success in comparison with current materials used; MTA and Biodentine. Methodology: An electronic search was performed during September 2021 in the PubMed-MEDLINE database. Human or In vitro comparative studies evaluating biocompatibility, clinical and radiographic success were included. No restriction was applied to the date of publication. Case series and expert opinions were excluded. Keywords such as "Theracal", "direct pulp capping", "Biodentine", "MTA" and "vital pulp treatment" were used. Results: Only one article was found that discussed the toxic effects of TheraCal. TheraCal has very favorable effects on the pulp, as it could be observed to induce dentin formation, these effects are to some extent limited. The solubility of TheraCal is one of its strongest characteristics, and it is very useful in indirect pulp capping, but not very useful in direct pulp capping. In comparison with other materials, Theracal shows good results that are considerably successful, however, the MTA and Biodentine variants present better percentages and higher probabilities of success. Conclusion: Theracal cannot be considered as a first-choice material when performing direct pulp treatment.

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Untitled

2022

Int. J. Appl. Dent. Sci.

0

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Introduction: Direct pulp treatment is a procedure in which the exposed vital pulp is treated with a therapeutic material, it is sought to promote healing, maintain pulp vitality and protect the pulp. Objective: To prove that TheraCal is the material of choice as a coating for direct pulp treatment in terms of biocompatibility and cytotoxicity, solubility and clinical management, effects on the pulp, clinical and radiographic success in comparison with current materials used; MTA and Biodentine. Methodology: An electronic search was performed during September 2021 in the PubMed-MEDLINE database. Human or In vitro comparative studies evaluating biocompatibility, clinical and radiographic success were included. No restriction was applied to the date of publication. Case series and expert opinions were excluded. Keywords such as "Theracal", "direct pulp capping", "Biodentine", "MTA" and "vital pulp treatment" were used. Results: Only one article was found that discussed the toxic effects of TheraCal. TheraCal has very favorable effects on the pulp, as it could be observed to induce dentin formation, these effects are to some extent limited. The solubility of TheraCal is one of its strongest characteristics, and it is very useful in indirect pulp capping, but not very useful in direct pulp capping. In comparison with other materials, Theracal shows good results that are considerably successful, however, the MTA and Biodentine variants present better percentages and higher probabilities of success. Conclusion: Theracal cannot be considered as a first-choice material when performing direct pulp treatment.

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Evaluation of the mechanical properties and biocompatibility of gypsum-containing calcium silicate cements

Cited by 6 publications

References 35 publications

Comparative Biocompatibility and Odonto-/Osteogenesis Effects of Hydraulic Calcium Silicate-Based Cements in Simulated Direct and Indirect Approaches for Regenerative Endodontic Treatments: A Systematic Review

Comparative Biocompatibility and Odonto-/Osteogenesis Effects of Hydraulic Calcium Silicate-Based Cements in Simulated Direct and Indirect Approaches for Regenerative Endodontic Treatments: A Systematic Review

TheraCal as the material of choice for direct pulp treatment compared to two other materials: MTA and biodentine

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