Evaluation of the migration of mutagens/carcinogens from PET bottles into mineral water by Tradescantia/micronuclei test, Comet assay on leukocytes and GC/MS

Biscardi, D; Monarca, Silvano; Fusco, R. De; Senatore, Felice; Poli, Paola; Buschini, Annamaria; Rossi, Carlo; Zani, Claudia

doi:10.1016/s0048-9697(02)00349-2

Cited by 88 publications

(55 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The migration of DEHP from PET into mineral water was reported by Biscardi et al (2003). Casajuana and Lacorte (2003) monitored several phthalates in mineral water and found increased concentrations of DMP, DEP, DBP, and DEHP after storing water in PET bottles for 10 weeks.…”

Section: Discussionmentioning

confidence: 89%

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Wagner

Oehlmann

2009

Environ Sci Pollut Res

294

178

View full text Add to dashboard Cite

Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled mineral water as model foodstuff and to characterize the potential sources of the estrogenic contamination. Materials, methods, and results In the present study, we analyzed commercially available mineral water in an in vitro system with the human estrogen receptor alpha and detected estrogenic contamination in 60% of all samples with a maximum activity equivalent to 75.2 ng/l of the natural sex hormone 17β-estradiol. Furthermore, breeding of the molluskan model Potamopyrgus antipodarum in water bottles made of glass and plastic [polyethylene terephthalate (PET)] resulted in an increased reproductive output of snails cultured in PET bottles. This provides first evidence that substances leaching from plastic food packaging materials act as functional estrogens in vivo.Discussion and conclusions Our results demonstrate a widespread contamination of mineral water with xenoestrogens that partly originates from compounds leaching from the plastic packaging material. These substances possess potent estrogenic activity in vivo in a molluskan sentinel. Overall, the results indicate that a broader range of foodstuff may be contaminated with endocrine disruptors when packed in plastics.

show abstract

Section: Discussionmentioning

confidence: 89%

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Wagner

Oehlmann

2009

Environ Sci Pollut Res

294

178

View full text Add to dashboard Cite

show abstract

“…Among these are the plasticizers, like the Di(2-ethylexyl)phthalate (DEHP) that is widely used as plasticizer and is also present in PET bottles (11). sunlight and high temperature) may contribute to the release of chemicals from bottles to water (32,58,59 (60). In an updated study, bioanalytical techniques and in vivo experiments with molluskan model are used to determine the estrogenicity of bottled water.…”

Section: Discussionmentioning

confidence: 99%

Natural mineral waters: chemical characteristics and health effects

Quattrini

Pampaloni

Brandi

2016

ccmbm

106

View full text Add to dashboard Cite

SummaryWater contributes significantly to health and a daily intake of 1.5 to 2 liters of water should be guaranteed, because a good hydration is essential to maintain the body water equilibrium, although needs may vary among people. However, worldwide population is far from the Recommended Allowance for water intake. Among the waters for human uses, there are 'waters (treated or not), intended for drinking, used for the food and beverages preparation or for other domestic purposes' and natural mineral waters, that are 'originated from an aquifer or underground reservoir, spring from one or more natural or bore sources and have specific hygienic features and, eventually, healthy properties'. According to the European Legislation (2009/54/EC Directive), physical and chemical characterization is used to make a classification of the different mineral waters, basing on the analysis of main parameters. Mineral composition enables to classify natural mineral waters as bicarbonate mineral waters, sulphate mineral waters, chloride mineral waters, calcic mineral waters, magnesiac mineral waters, fluorurate mineral waters, ferrous mineral waters and sodium-rich mineral waters. Although the concerns about bottled mineral waters (due to plasticizers and endocrine disruptors), many are the health effects of natural mineral waters and several studies explored their properties and their role in different physiological and pathological conditions.

show abstract

“…Evandri et al (2000) showed that genotoxic activity was present in water samples after 8 weeks regardless of light exposure. Biscardi et al (2003) observed mutagenic behaviour not only in water samples without light exposure during mineral bottle storage but also from pipes supplying water for the bottling process.…”

Section: Solar Disinfection (Sodis) Is a Water Treatment Methodsmentioning

confidence: 90%

“…A similar study conducted by Monarca et al (1994) revealed no mutagenic activity in the mineral water after 1 month of storage. Evandri et al (2000) and Biscardi et al (2003) used two plant-based genotoxic assays, Allium cepa and Tradescantia/micronuclei, respectively, to evaluate migration of mutagens from PET bottles. These plant assays have been used to test genotoxicity in drinking water and can be used for unconcentrated samples as well.…”

Section: Solar Disinfection (Sodis) Is a Water Treatment Methodsmentioning

confidence: 99%

A preliminary Ames fluctuation assay assessment of the genotoxicity of drinking water that has been solar disinfected in polyethylene terephthalate (PET) bottles

Ubomba-Jaswa

Fernández‐Ibáñez

McGuigan

2010

Journal of Water and Health

View full text Add to dashboard Cite

Though microbially safe, concerns have been raised about the genotoxic/mutagenic quality of solar-disinfected drinking water, which might be compromised as a result of photodegradation of polyethylene terephthalate (PET) bottles used as SODIS reactors. This study assessed genotoxic risk associated with the possible release of genotoxic compounds into water from PET bottles during SODIS, using the Ames fluctuation test. Negative genotoxicity results were obtained for water samples that had been in PET bottles and exposed to normal SODIS conditions (strong natural sunlight) over 6 months. Under SODIS conditions, bottles were exposed to 6 h of sunlight, followed by overnight room temperature storage. They were then emptied and refilled the following day and exposed to sunlight again. Genotoxicity was detected after 2 months in water stored in PET bottles and exposed continuously (without refilling) to sunlight for a period ranging from 1 to 6 months. However, similar genotoxicity results were also observed for the dark control (without refill) samples at the same time-point and in no other samples after that time; therefore it is unlikely that this genotoxicity event is related to solar exposure.

show abstract

Evaluation of the migration of mutagens/carcinogens from PET bottles into mineral water by Tradescantia/micronuclei test, Comet assay on leukocytes and GC/MS

Cited by 88 publications

References 22 publications

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Natural mineral waters: chemical characteristics and health effects

A preliminary Ames fluctuation assay assessment of the genotoxicity of drinking water that has been solar disinfected in polyethylene terephthalate (PET) bottles

Contact Info

Product

Resources

About