Evaluation of the molluscicidal and Schistosoma mansoni cercariae activity of Croton floribundus extracts and kaurenoic acid

Medina, Janaina M.; Peixoto, Juliana Luna Bilheiro; Silva, Adriano A.; Haraguchi, Shirani Kaori; Falavigna, Dina Lúcia Morais; Zamuner, M L M; Sarragiotto, María Helena; Vidotti, Gentil J.

doi:10.1590/s0102-695x2009000200005

Cited by 14 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The molluscicidal activity was not observed for both extracts tested on Biomphalaria glabrata snails in the evaluated concentrations (200, 100 and 50 µg/ml). Medina et al (2009) reported significant molluscicidal and cercaricidal activities against adult Biomphalaria glabrata snails and Schistosoma mansoni cercariae for alcoholic extracts of leaves and barks of C. floribundus and the isolated compound, kaurenoic acid. The lack of activity observed in our study can be related to the non-production of active metabolites in the studied plant, since the production of secondary metabolites in plants can be influenced by several factors like seasonality, type of soil, weather, rainfall, radiation or any other condition (Al-Zanbagi et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

“…The fruits are considered tonic. According Medina et al (2009), the alcoholic extracts of leaves and barks and the isolated compound, kaurenoic acid, showed significant molluscicidal and cercaricidal activities against adult Biomphalaria glabrata snails and Schistosoma mansoni cercariae, respectively. In other work, the ent-kaur-16-en-6α,19-diol isolated from hexane extract of root bark showed moderate effect against three cancer cell lines: MDA-MB-435 (melanoma), HCT-8 (colorectal adenocarcinoma) and HCT-116 (colorectal adenocarcinoma) (Uchoa et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

et al. 2018

View full text Add to dashboard Cite

This work describes the preliminary evaluation of cytotoxic, antimicrobial, molluscicidal, antioxidant and anticholinesterase activities from leaf (LECF) and stem bark alcoholic extracts (BECF) of the species Croton floribundus Spreng. (Euphorbiaceae), popularly known as capixingui or tapixingui. BECF presented significant toxicity (LC50 = 89.6 μg/ml) in the Artemia salina Leach, 1819 (Crustacea: Branchiopoda) bioassay, whereas LECF did not show activity (LC50 > 1000 μg/ml). From DPPH method, the values of IC50 for the LECF and BECF were 61.2 μg/ml and 62.2 μg/ml, respectively, showing that C. floribundus has an expressive antioxidant activity. Antimicrobial susceptibility was evaluated by microdilution technique and only BECF was active against Staphylococcus aureus (MIC = 39.6 μg/ml). The extracts did not present molluscicidal activity against snail Biomphalaria glabrata Say, 1818 (Gastropoda: Planorbidae). Both extracts revealed the presence of several components with an inhibiting capacity of acetylcholinesterase enzyme on the bioautographic assay. C. floribundus showed to be a promising species considering that it exhibited good biological activity in the most assays performed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A previous study with CUR also demonstrated high activity on S japonicum cercariae, with 100% cercariae mortality at a concentration of 8 μg mL −1 after 30 min . Other compounds, such as kaurenoic acid isolated from Croton floribundus , have also demonstrated the cercaricidal effect on S. mansoni cercariae, with 100% cercariae mortality at a concentration of 100 μg mL −1 after 1 h of exposure . Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control.…”

Section: Discussionmentioning

confidence: 99%

“…30 Other compounds, such as kaurenoic acid isolated from Croton floribundus, have also demonstrated the cercaricidal effect on S. mansoni cercariae, with 100% cercariae mortality at a concentration of 100 μg mL −1 after 1 h of exposure. 48 Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control. In agreement with other reports, PZQ causes 100% mortality of S. mansoni and S. japonicum cercariae at concentrations of 1, 8 and 12.5 μg mL −1 between 0.30 and 3 h. 30,36,49 CUR toxicity related to other environment organisms was not evaluated in this study; however, CUR showed no toxic effect and systemic abnormalities in a higher dose (1.5 mg) against Labeo rohita fish.…”

Section: Discussionmentioning

confidence: 99%

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Matos

Silva

Paula

et al. 2019

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND Schistosomiasis control in endemic areas depends on several factors, including chemotherapy, snail control and adequate sanitation. In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from Curcuma longa, against snails and embryos of Biomphalaria glabrata, which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of Schistosoma mansoni. RESULTS CUR presented high activity against B. glabrata embryos and moderate activity against newborn and adult snails. The lethal concentration (LC50) values after being exposed for 24 h and evaluated for 7 days were 6.54 (95% confidence interval (CI) 5.86–7.30) μg mL−1 for the embryos and 42.29 (95% CI 33.82–52.87) μg mL−1 and 87.69 (95% CI 68.82–111.7) μg mL−1 for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC50 values lower than 10 μg mL−1 at 1, 3, 6, 9 and 12 h, respectively. CONCLUSION Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. © 2019 Society of Chemical Industry

show abstract

“…glabrata snails at concentrations of 50 ppm [263]. glabrata adult snails [269]. glabrata and their eggs [264,265].…”

Section: Schistosomiasismentioning

confidence: 99%

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

Oliveira

Chiaradia-Delatorre²,

Mascarello³

et al. 2015

Studies in Natural Products Chemistry

View full text Add to dashboard Cite

Evaluation of the molluscicidal and Schistosoma mansoni cercariae activity of Croton floribundus extracts and kaurenoic acid

Cited by 14 publications

References 14 publications

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

Biological screening of extracts from leaf and stem bark of Croton floribundus Spreng. (Euphorbiaceae)

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

Contact Info

Product

Resources

About