Evaluation of the Nano Spray Dryer B-90 for pharmaceutical applications

Abstract

The vibrating mesh spray technology implemented in the Nano Spray Dryer B-90 was evaluated for pharmaceutical applications by spray drying common pharmaceutical excipients (e.g. trehalose, mannitol) and model drugs (e.g. griseofulvin). Aerosol droplet size measurements investigated the influence of spray solution factors (e.g. viscosity, surface tension) and of vibrating mesh aperture sizes on particle characteristics. Particle deposition on the spray nozzle was addressed by analyzing the influence of spray solute concentration and solvent on the process outcome. Submicron particles with 0.5 ?m and 0.8 ?m mean particle size were obtained at high yields for 50?mg powder amounts.

Spray-dried Respirable Powders Containing Bacteriophages for the Treatment of Pulmonary Infections

“…The manufacturing setup is shown in Figure 2. The spray dryer used a vibrating mesh atomizer with 111 orifices each having a diameter of 4 :m corresponding to an atomized droplet diameter of 7 :m. 46,47 The feedstock was circulated through the spray head at atmospheric pressure. A cellulose acetate and cellulose nitrate membrane filter with a pore width of 0.45 :m was used in line for filtration of the feedstock.…”

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

“…This device is suitable for the production of fine particles (300 nm-5 µm) with satisfactory yield, even for small sample amounts (milligrams) [61,62]. This feature is very relevant especially at the very early stages of product development and when expensive materials, such as monoclonal antibodies, are used [63].…”

Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies

“…The setup comprises three subunits: (1) an atomization system composed of a piezoelectric actuator driven at an ultrasonic frequency (60 kHz) generating a fine aerosol of droplets with controlled size; (2) a glass dry tower with a laminar air flow promoting fast drying of droplets into dry particles using a gentle heating system; (3) an electrostatic particle collector consisting of a star electrode (cathode) and a cylindrical particle collecting electrode (anode) with an applied high voltage causing the electrostatic deposition of particles on the surface of the cylindrical electrode. In contrast to traditional spray-drying, in which very small particles (< 2 µm) are lost during the drying process, this new equipment allows collecting particles in the submicron scale [22,23]. Vibrational atomization spray-drying has been studied to produce polymeric or nonpolymeric particles with a range from 300 nm to 5 μm intended for several pharmaceutical applications, including cerebral [24], oral [25], ophthalmic [26] and pulmonary administration [27][28][29].…”