Evaluation of the Need for Antibiotic Prophylaxis During Routine Intra-alveolar Dental Extractions in Healthy Patients: A Randomized Double-Blind Controlled Trial

Antibiotic prescribing practices of dentists at Medunsa Oral Health Centre

“…The review further concluded that patients at higher risk of infection, the risk may be up to 25% in patients who are already sick or have low immunity, are more likely to benefit from prophylactic antibiotics, because infections in this group are likely to be more frequent, associated with complications and be more difficult to treat. 37 A more recent prospective cohort study corroborates these reviews. 39 The results of this study indicate that 3.2% of antibiotics were dispensed to treat pericoronitis.…”

“…15,36 However, patients at higher risk of infection are more likely to benefit from Routine dental extractions prophylactic antibiotics. 37 Akinbami and Osagbemiro (2015) found that the type of extraction, difficulty of extraction and adherence to postoperative instructions were important associated factors that determined the occurrence of postoperative complications. 15 The issue of prophylactic antibiotic therapy in third molar surgery in healthy patients is highly controversial.…”

A comparative analysis of the efficacy of moxifloxacin and cefixime in the reduction of postoperative inflammatory sequelae after mandibular third molar surgery

“…Table 6 Insert for Table 7 Discussion At present, as a part of the impacted mandibular third molar surgery, especially in private dental practice settings, antibiotics are often routinely prescribed due to the prevalent view (which is not based on scientific evidence) that this promotes a safer postoperative course, with fewer postoperative sequelae that commonly accompany this intervention. However, such potentially unnecessary use of antibiotics may lead to adverse consequences (development of resistant microorganism strains and increased risk of allergy to prescribed antibiotics), which is why many researchers do not support routine antibiotic use following mandibular third molar surgery unless preoperative infection (pericoronitis) is diagnosed [14][15][16][17][18] . Therefore, the aim of the present double-blind prospective study was to evaluate the efficacy of antibiotic prophylaxis in mitigating discomfort (inflammatory sequelae and dry socket) that most frequently occur after the impacted mandibular third molar surgery.…”

“…Authors of numerous articles published in professional and scientific literature advocate for the prophylactic use of antibiotics as a part of the surgical extraction of mandibular third molars and provide the reasons for this recommendation [10][11][12][13] , while others offer equally compelling reasons for their disagreement with this approach [14][15][16][17][18] . However, neither of these opposing views is founded on scientific evidence.…”

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

“…383,384 Although the recommendations for the administration of antibiotics to prevent infective endocarditis remain unchanged, 383 there is accumulating evidence that antibiotics cannot prevent infectious complications after dental extractions effectively and should not be used. [384][385][386] In every patient, clinicians should carefully weigh the risks (adverse events, antibiotic resistance) and benefits of the application of prophylactic antibiotics, considering the obvious lack of evidence supporting this practice in many situations.…”