Evaluation of the Neurobehavioral Functioning Inventory as a Depression Screening Tool After Traumatic Brain Injury

Kennedy, Richard E.; Livingston, L; Riddick, Amy; Marwitz, Jennifer H.; Kreutzer, Jeffrey S.; Zasler, Nathan D.

doi:10.1097/00001199-200511000-00004

Cited by 42 publications

(25 citation statements)

References 34 publications

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“…One reason for these fi ndings could be the patients' chronic condition of having to face daily living diffi culties. Indeed, this could have clinical implications for emotional distress, such as depression or anxiety (Jorge & Robinson, 2002 ;Kennedy, Livingston, Riddick, Marwitz, Kreutzer, & Zasler, 2005 ;Kreutzer, Seel, & Gourley, 2001 ;Rao & Lyketsos, 2000 ). It could be that neuropsychological factors contribute to unawareness and that heightened awareness is infl uenced by emotional factors.…”

Section: Discussionmentioning

confidence: 99%

Metacognitive unawareness correlates with executive function impairment after severe traumatic brain injury

Ciurli

Bivona

Barba

et al. 2010

J Int Neuropsychol Soc

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A neuropsychological battery was used to evaluate attention, memory and executive functions. SA was assessed by the PCRS, which was administered to patients and close family members. Patients were divided into two groups representing those with and without SA. Patients with poor SA had more problems than those with good SA in some components of the executive system, as indicated by the high percentage of perseverative errors and responses they made on the Wisconsin Card Sorting Test. Moreover, a decrease in metacognitive SA correlated significantly with time to follow commands (TFC). This study suggests the importance of integrating an overall assessment of cognitive functions with a specific evaluation of SA to treat self-awareness and executive functions together during the rehabilitation process.

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Section: Discussionmentioning

confidence: 99%

Metacognitive unawareness correlates with executive function impairment after severe traumatic brain injury

Ciurli

Bivona

Barba

et al. 2010

J Int Neuropsychol Soc

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“…There is consistent evidence that depressed mood (A1) in persons with TBI is more frequently evidenced by irritability, frustration, anger, and aggression than by sadness, feeling blue, or tearfulness. 15,35,36 High levels of self-reported somatic and cognitive symptoms that exceed objective findings also strongly distinguish persons with and without depressed mood. 35 Diminished interest or pleasure (A2) in persons with TBI commonly centers on difficulty enjoying activities, loss of interest in sex, and loneliness.…”

Section: Major Depression-diagnostic Featuresmentioning

confidence: 99%

“…35 Diminished interest or pleasure (A2) in persons with TBI commonly centers on difficulty enjoying activities, loss of interest in sex, and loneliness. 15,36 Poor appetite (A3) is more frequently reported by persons with TBI than overeating and may be a primary discriminator between depressed and nondepressed persons with TBI. 36 Rumination, self-criticism, and guilt are closely related to feelings of worthlessness (A7) and appear to highly differentiate depressed from nondepressed persons with TBI.…”

Section: Major Depression-diagnostic Featuresmentioning

confidence: 99%

Clinical Considerations for the Diagnosis of Major Depression After Moderate to Severe TBI

Seel¹,

Macciocchi²,

Kreutzer³

2010

Journal of Head Trauma Rehabilitation

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Major depression (MD) is the most common psychiatric disorder after traumatic brain injury (TBI). Yet, diagnosing MD is often challenging because of cognitive, emotional, and somatic symptoms that overlap with TBI and other psychiatric disorders. Best current evidence suggests that depressed mood is characterized more by irritability, anger, and aggression than by sadness and tearfulness in persons with TBI. Rumination, self-criticism, and guilt may best differentiate depressed persons from nondepressed persons. Anxiety, aggression, sleep problems, alcohol use, lower-income levels, and poor social functioning appear to be primary associated factors to MD. Objective levels of injury severity, impairment, and functioning do not appear to be related to developing MD. The presence of "organic" TBI sequelae that overlap with the Diagnostic and Statistical Manual of Mental Disorders-Version IV MD criteria does not appear to lead to false-positive MD diagnoses, and anosognosia does not appear to lead to false-negative MD diagnoses. Only the Patient Health Questionnaire-9 and Neurobehavioral Functioning Inventory-Depression demonstrated evidence of acceptably ruling out MD in persons with TBI; the Patient Health Questionnaire-9 had the best ability to rule in the presence of MD following TBI. Apathy, anxiety, dysregulation, and emotional lability require careful clinical consideration when making a differential diagnosis of MD in persons with TBI. Lastly, recommendations are provided on how clinicians can improve diagnostic accuracy and what future research is required to improve our understanding of MD in persons with TBI.

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“…4 Depression is the most frequently diagnosed psychiatric disorder after TBI. 5,6 Nearly half of those with TBI experience major depressive disorder (MDD) in the first year. 7 Despite the high prevalence of affective disorders after TBI, the pathophysiological mechanisms still remain to be defined.…”

Section: Introductionmentioning

confidence: 99%

Involvement of Extracellular Signal Regulated Kinases in Traumatic Brain Injury-Induced Depression in Rodents

Kuo

Cheng

Chen

et al. 2013

Journal of Neurotrauma

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Traumatic brain injury (TBI) is the most common cause of death and acquired disability among children and young adults in the developed countries. In clinical studies, the incidence of depression is high after TBI, and the mechanisms behind TBI-induced depression remain unclear. In the present study, we subjected rats to a moderate fluid percussion into the closed cranial cavity to induce TBI. After 3 days of recovery, injured rats were given a forced swim test (FST) and novelty-suppressed feeding tests. We found that TBI rats exhibited increased duration of immobility and longer latency to begin chewing food in a new environment compared with sham-operated rats. Western blot analysis showed that TBI led to a decrease in the phosphorylated levels of extracellular signal regulated kinases (ERK1/2) and p38 mitogenactivated protein kinase (p38 MAPK). Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), significantly reduced the duration of immobility when administered once per day for 14 days. Consistent with behavioral tests, fluoxetine treatment reversed TBI-induced decrease in p-ERK1/2 and p-p38 MAPK levels. Pre-treatment with a selective tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA) blocked the antidepressant effect of fluoxetine. PCPA also prevented the effect of fluoxetine on ERK1/2 phosphorylation without affecting p38 MAPK phosphorylation. Pre-treatment with ERK inhibitor SL327 but not p38 MAPK inhibitor SB203580 prevented the antidepressant effect of fluoxetine. These results suggest that ERK1/2 plays a critical role in TBI-induced depression.

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Evaluation of the Neurobehavioral Functioning Inventory as a Depression Screening Tool After Traumatic Brain Injury

Cited by 42 publications

References 34 publications

Metacognitive unawareness correlates with executive function impairment after severe traumatic brain injury

Metacognitive unawareness correlates with executive function impairment after severe traumatic brain injury

Clinical Considerations for the Diagnosis of Major Depression After Moderate to Severe TBI

Involvement of Extracellular Signal Regulated Kinases in Traumatic Brain Injury-Induced Depression in Rodents

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