Evaluation of the OptiMAL Test for Rapid Diagnosis of
            <i>Plasmodium vivax</i>
            and
            <i>Plasmodium falciparum</i>
            Malaria

Palmer, Carol; Lindo, John; Klaskala, Winslow; Quesada, José A.; Kaminsky, Rina Girard de; Baum, Marianna K.; Ager, Arba L.

doi:10.1128/jcm.36.1.203-206.1998

Cited by 195 publications

(65 citation statements)

References 14 publications

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“…Early diagnosis and prompt treatment of clinical malaria is one of the key strategies for reducing malaria morbidity and mortality. Although diagnostic accuracy can be improved signi®cantly with microscopy or dipstick (Palmer et al 1998), these tools are often not available in rural areas where health workers with a low level of formal clinical training are the main treatment providers for febrile illnesses. Administering presumptive treatment for malaria to everyone who presents with fever or with a history of fever is common practice in many countries.…”

Section: Introductionmentioning

confidence: 99%

A clinical algorithm for the diagnosis of malaria: results of an evaluation in an area of low endemicity

Chandramohan

Carneiro

Kavishwar

et al. 2001

Tropical Med Int Health

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SummaryWe conducted a study of 1945 children and 2885 adults who presented with fever to a hospital outpatients clinic in an urban area of India order to develop and evaluate a clinical algorithm for the diagnosis of malaria. Only 139 (7%) children and 349 (12%) adults had microscopically con®rmed malaria. None of the symptoms or signs elicited from the respondents were good predictors of clinical malaria. Simple scores were derived through combining clinical features which were associated with slide positivity or were judged by clinicians to be important. The best-performing algorithms were a score of 4 clinical features in children (sensitivity 60.0% and speci®city 61.2%) and a score of 5 in adults (sensitivity 54.6% and speci®city 57.5%). The clinical features differed and algorithm performances were poorer than in previous studies in highly endemic areas. The conclusion is that malaria diagnosis in areas of low endemicity requires microscopy to be accurate.keywords clinical diagnosis, malaria, algorithm, validity correspondence Daniel Chandramohan,

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Section: Introductionmentioning

confidence: 99%

A clinical algorithm for the diagnosis of malaria: results of an evaluation in an area of low endemicity

Chandramohan

Carneiro

Kavishwar

et al. 2001

Tropical Med Int Health

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“…Molecular diagnostic technologies that are either already in use or are being tested in low-income regions include the polymerase chain reaction (PCR), monoclonal antibodies, and recombinant antigens. 41 Daar et al report that:…”

Section: Products and Interventions For Low-income Settingsmentioning

confidence: 99%

The Social Value of Health Research and the Worst Off

Barsdorf¹,

Millum²

2017

Bioethics

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In this article we argue that the social value of health research should be conceptualized as a function of both the expected benefits of the research and the priority that the beneficiaries deserve. People deserve greater priority the worse off they are. This conception of social value can be applied for at least two important purposes: (1) in health research priority setting when research funders, policy-makers, or researchers decide between alternative research projects; and (2) in evaluating the ethics of proposed research proposals when research ethics committees (RECs) assess whether the social value of the research is sufficient to justify the risks and burdens to research participants and others. In assessing how far a proposed research project will advance the interests of people who are more disadvantaged, research priority setters and RECs should examine (at least) the diseases that the research targets and the type of research. Just as certain diseases impose a greater burden on people who are more disadvantaged, so certain types of intervention and forms of research are more likely to benefit people who are more disadvantaged. We outline which populations are likely to be representative of the global worst off and identify what types of health research, and which disease categories, are priorities for these populations.

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“…â reported an overall sensitivity of 20 %-79 % [15,16,19,20]. The OptiMAL â test yielded a somewhat better sensitivity of 69 %-93 % [19,21,22].…”

Section: Sensitivitymentioning

confidence: 99%

“…In contrast, pLDH depends on the presence of living parasites. Monitoring the presence of pLDH with the corresponding RDTs may therefore be more suitable to evaluate response to treatment [22,23]. Field studies are currently under way to clarify this issue [24].…”

Section: Specificitymentioning

confidence: 99%

“…In these situations, that are often complicated by concomitant infectious diseases, RDTs may be a useful tool to quickly assess the dimension and nature of the outbreak and to direct limited drug resources to those who would benefit most from treatment. According to Palmer et al, the use of an RDT kit was very effective during a malaria outbreak in Honduras, in an area where dengue fever is very common [22]. Singh et al found RDTs very helpful in the management of seasonal outbreaks in remote regions of India [18].…”

Section: The Role Of Rdts In Regions With Low To Moderate Malaria Tramentioning

confidence: 99%

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Malaria Rapid Tests - Perspectives for Malaria Endemic and Non-Endemic Regions. Malariaschnelltests - Perspektiven fur Regionen mit und ohne endemischer Malaria

Schmidt

2003

Laboratoriums Mediz

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Summary: Rapid, reliable and affordable diagnostic means are indispensable for the diagnosis and treatment of malaria. Recently, immunochromatographic rapid tests (RDT) for the detection of malaria parasites in blood have been developed as an alternative to conventional diagnosis with light microscopy. Currently available tests target different Plasmodium‐specific antigens, and some RDTs also allow the differentiation of malaria tropica (P. falciparum) from the other forms. The performance RDTs in terms of sensitivity, specificity, positive and negative predictive value, and reliability is discussed. For most parameters, various studies have shown an acceptable or good test performance. Of concern is the failure of RDTs to diagnose individual cases of high parasitemia. In highly endemic regions, the utility of RDTs is limited. In these regions, the widespread prevalence of asymptomatic parasitemia leads to a high rate of false positive test results. RDTs seem to be most useful in areas with low to moderate malaria transmission, especially in the presence of multiple drug resistance. They are useful in the management of malaria outbreaks within populations with a low degree of malaria specific immunity. RDTs can help inexperienced hospital staff in non‐endemic regions to diagnose cases of imported malaria. The self‐use of RDTs by travellers is subject to controversy. In conclusion, RDTs are an additional tool for the diagnosis of malaria but in most settings do not replace light microscopy.

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Evaluation of the OptiMAL Test for Rapid Diagnosis of Plasmodium vivax and Plasmodium falciparum Malaria

Cited by 195 publications

References 14 publications

A clinical algorithm for the diagnosis of malaria: results of an evaluation in an area of low endemicity

A clinical algorithm for the diagnosis of malaria: results of an evaluation in an area of low endemicity

The Social Value of Health Research and the Worst Off

Malaria Rapid Tests - Perspectives for Malaria Endemic and Non-Endemic Regions. Malariaschnelltests - Perspektiven fur Regionen mit und ohne endemischer Malaria

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