Evaluation of the outcome of various laser therapy applications in root canal disinfection: A systematic review

Bordea, Ioana Roxana; Hanna, Reem; Chiniforush, Nasim; Grădinaru, Elena; Câmpian, Radu Septimiu; Sîrbu, Adina; Amaroli, Andrea; Benedicenti, Stefano

doi:10.1016/j.pdpdt.2019.101611

Cited by 66 publications

(63 citation statements)

References 104 publications

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“…The literature seems to be agreeing with the use of PDT as an adjunctive tool to the chemomechanical endodontic techniques, particularly in persistent endodontic infection conditions [13,15]. Pourhajibagher et al showed a significant reduction of diversity and number of bacteria in an in-vivo study on patients with secondary or persistent endodontic infections after PDT with TB [21].…”

Section: Discussionmentioning

confidence: 83%

“…The heterogeneity of outcomes may be due to the presence of several sensitive factors in the PDT protocol that may affect the outcomes, including the type of PS, its concentration, its pre-irradiation time, the laser's wavelength, the irradiance time, the type of irrigant, its exposure time, the bacterial biofilms, and the utilized microbiological technique to evaluate the colony counts [14,15,23].…”

Section: Discussionmentioning

confidence: 99%

“…In a study on infected extracted teeth with E. faecalis, the greatest culture-negative samples were noted with the 3% NaOCl-irrigation-alone protocol in the secondary infection cases [24]. In fact, the heterogeneity of reported data and the absence of a standardized protocol of PDT were noted in a recent systemic review [15].…”

Section: Discussionmentioning

confidence: 99%

“…Recent systematic reviews have found that the outcome of PDT in removing endodontic biofilms from infected root canals is still not completely clear. This may be due to the diversity in the studies' methodology and PDT protocols [13][14][15]. Some authors have demonstrated better results of PDT through improving the evaluation methodology of the antibacterial effect [4].…”

Section: Introductionmentioning

confidence: 99%

“…It is believed that studies with similar PS type and light source cannot be compared when the irradiation protocol, irradiation time, laser parameters, and PS concentration are different [13]. Therefore, carrying out further studies to achieve a standardized protocol of PDT is still recommended [13][14][15]. Our study aimed to evaluate the antimicrobial effect of photodynamic therapy using a diode laser 635 nm and TB solution on freshly extracted teeth infected with biofilms of E. faecalis.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Photodynamic Therapy Using a Diode Laser 635 nm as an Adjunct to Conventional Chemo-Mechanical Endodontic Procedures against Enterococcus faecalis Biofilm: Ex-Vivo Study

et al. 2020

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The study aimed to evaluate the antimicrobial effect of photodynamic therapy (PDT) with the use of Toluidine Blue (TB) on extracted teeth infected with biofilms of Enterococcus faecalis. Fifty-four extracted teeth with single-roots and single canals were mechanically shaped, autoclaved, and contaminated with E. faecalis. They were randomly divided into six groups: two groups were negative and positive control groups, two groups were subjected to mechanical instrumentation and PDT with different pre-irradiation times and irradiation times, and two groups were subjected to chemo-mechanical endodontic treatment and PDT with different pre-irradiation times and irradiation times. In PDT groups, after the application of TB, the canals were irradiated with a diode laser of wavelength 635 nm, with a fiber diameter of 200 μm and 100 mW of power in continuous mode. The bacterial load was evaluated using a BioTimer Assay protocol. The greatest reduction of bacterial load was observed in groups of combined PDT with chemo-mechanical treatment. The reductions of bacterial load in groups of combined PDT with chemo-mechanical treatment, and in the positive control group, were significant (p < 0.01) when compared to that of the negative control group. Photodynamic therapy as an adjunctive modality may improve the disinfection capacity of conventional endodontic treatment against E. faecalis.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Photodynamic Therapy Using a Diode Laser 635 nm as an Adjunct to Conventional Chemo-Mechanical Endodontic Procedures against Enterococcus faecalis Biofilm: Ex-Vivo Study

et al. 2020

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Evaluation of the effects of different photosensitizers used in antimicrobial photodynamic therapy on tooth discoloration: spectrophotometric analysis

Şahin,

Korucu,

Aydin

2024

Lasers Med Sci

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Background Tooth discoloration is a common concern in antimicrobial photodynamic therapy (aPDT) using various photosensitizers (PS). Toluidine Blue (TB), Methylene Blue (MB), Phthalocyanine (Pc), and 2-mercaptopyridine-substituted zinc phthalocyanine (TM-ZnPc) are among those studied, but their relative impacts on tooth discoloration remain unclear. Aim This study aimed to compare the effects of TB, MB, Pc, and TM-ZnPc in aPDT on tooth discoloration, utilizing a controlled experimental setup. Materials and Methods The study comprised seventy-five single-rooted incisors with root canals. Following meticulous preparation, a standardized area on the crown surface was designated for examination, and precise measurements of the initial tooth colors were recorded. Samples were randomly divided into five groups: Negative control, MB, TM, Pc, and TM-ZnPc. Photoactivation was performed using LED light, and color measurements were taken at multiple time points up to 90 days. Data were converted to Lab* color values of the CIE Lab* color system (International Commission on Illumination, Vienna, Austria), and ΔE values were calculated. Statistical analysis was performed using Two-way ANOVA and Post-Hoc Tukey tests (p < 0.05). Results At day 7 and 30, TM-ZnPc and Pc caused less discoloration compared to MB and TB. TM-ZnPc caused more tooth discoloration compared to Pc (p < 0.05). Compared to baseline, MB and TM-ZnPc caused more tooth discoloration at 30 days and TB caused more tooth discoloration at 90 days (p < 0.05). No significant difference was observed in terms of tooth discoloration at all periods evaluated after Pc application (p > 0.05). All photosensitizers tested in the study caused tooth coloration. Conclusion All PS induced clinically detectable tooth discoloration, with TB and MB causing more significant discoloration compared to Pc and TM-ZnPc at certain time points. TM-ZnPc and Pc demonstrated more stable coloration levels over time, suggesting their potential reliability in aPDT applications. This study highlights the importance of selecting appropriate PS to minimize tooth discoloration in aPDT, with Pc showing promise in this regard.

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Can laser therapy used in endodontic treatment improve apical periodontitis repair? A systematic review

et al. 2021

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Evaluation of the outcome of various laser therapy applications in root canal disinfection: A systematic review

Cited by 66 publications

References 104 publications

Evaluation of Photodynamic Therapy Using a Diode Laser 635 nm as an Adjunct to Conventional Chemo-Mechanical Endodontic Procedures against Enterococcus faecalis Biofilm: Ex-Vivo Study

Evaluation of Photodynamic Therapy Using a Diode Laser 635 nm as an Adjunct to Conventional Chemo-Mechanical Endodontic Procedures against Enterococcus faecalis Biofilm: Ex-Vivo Study

Evaluation of the effects of different photosensitizers used in antimicrobial photodynamic therapy on tooth discoloration: spectrophotometric analysis

Can laser therapy used in endodontic treatment improve apical periodontitis repair? A systematic review

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