2016
DOI: 10.1371/journal.pone.0161621
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Evaluation of the Performance of Five Diagnostic Tests for Fasciola hepatica Infection in Naturally Infected Cattle Using a Bayesian No Gold Standard Approach

Abstract: The clinical and economic importance of fasciolosis has been recognised for centuries, yet diagnostic tests available for cattle are far from perfect. Test evaluation has mainly been carried out using gold standard approaches or under experimental settings, the limitations of which are well known. In this study, a Bayesian no gold standard approach was used to estimate the diagnostic sensitivity and specificity of five tests for fasciolosis in cattle. These included detailed liver necropsy including gall bladd… Show more

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Cited by 68 publications
(71 citation statements)
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“…Infection can be also confirmed at necropsy and many farmers use abattoir returns to identify if F. hepatica is present in their livestock (Mazeri, Sargison, Kelly, Bronsvoort, & Handel, ).…”
Section: Diagnosismentioning
confidence: 99%
See 1 more Smart Citation
“…Infection can be also confirmed at necropsy and many farmers use abattoir returns to identify if F. hepatica is present in their livestock (Mazeri, Sargison, Kelly, Bronsvoort, & Handel, ).…”
Section: Diagnosismentioning
confidence: 99%
“…Infection can be also confirmed at necropsy and many farmers use abattoir returns to identify if F. hepatica is present in their livestock (Mazeri, Sargison, Kelly, Bronsvoort, & Handel, 2016). The MM3-COPRO test, based on the MM3 MoAb that binds to both CatL1 and CatL2 proteases (Mezo, Gonz alez-Warleta, Carro, & Ubeira, 2004), is commercialized by BIO X Diagnostics (La Jemelle, Belgium).…”
Section: Diagnosismentioning
confidence: 99%
“…As Th1 responses are associated with lesion development in bTB, the presence of liver fluke infection could promote a shift towards a Th2‐type immune response and potentially restrain the progression of lesion development. It should be noted that surveillance data have less than perfect sensitivity or specificity in detecting liver fluke (recent European studies suggest sensitivity of 0.63–0.68 and specificity 0.88–1.00; Mazeri, Sargison, Kelly, Bronsvoort, & Handel, ; Rapsch et al., ), which could impact on our inferences here (potentially conservatively biasing our inferences towards the null; Schennach, ). Indeed, similarly, the ability to detect bTB visible lesions at slaughter is less than perfect (though specificity is close to 1; Lahuerta‐Marin et al., ), which is a general limitation to these study types (e.g., Downs et al., ; O'Hagan et al., ; Olea‐Popelka et al., ; Wright et al., ).…”
Section: Discussionmentioning
confidence: 89%
“…Several draft genome efforts are reported for S. mansoni [54] and S. haematobium [55], similar efforts detailing transcriptomics and proteomics data sets for S. japonicum are available [52,56,57]. A number of expressed sequence tags have been described for Fish-borne zoonotic trematodes such as O. viverrini [58], and the sequence of genes coding for hundreds of important invasive factors are described for F. hepatica [28,59].…”
Section: Genomics Of Zoonotic Trematodiasismentioning
confidence: 99%