Evaluation of the Performance of GenoType® MTBDR<i>plus</i>Assay for Rapid Detection of Multi-drug Resistant<i>Mycobacterium tuberculosis</i>in Sputum Specimens

Recurrent tuberculosis can be caused by a relapse of the original infecting strain, a re infection with a new strain of Mycobacterium tuberculosis or a paradoxical response associated with the anti-tuberculosis treatment. A drug susceptibility test is important when evaluating recurrent tuberculosis but a conventional microbiological test may be unavailable or unsuccessful. Recently, direct molecular testing as a line probe assay (GenoType ® MTBDRplus, Hain Lifescience GmbH, Nehren, Germany) has shown promising results for the diagnosis or treatment of drug-resistant tuberculosis.We present two cases of rifampin-resistant, relapsed tuberculosis that were confirmed using a molecular technique.

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Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Moon

Lee

Choi

et al. 2012

Infect Chemother

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Evaluation of the AdvanSure MDR-TB GenoBlot Assay for Detection of Rifampin and Isoniazid ResistantMycobacterium tuberculosisComplex in Respiratory Specimens

Kim

Park

Lee

et al. 2012

Korean J Clin Microbiol

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a total of 542 M. tuberculosis clinical isolates were collected from pulmonary tuberculosis patients in six university hospitals across Korea. We analyzed the conventional drug susceptibility testing (DST) and compared the results with those of the AdvanSure MDR-TB. Results: Compared with the conventional DST, the overall agreement rates, sensitivity, and specificity were 98.2% (532/542), 84.6% (33/39), and 99.2% (499/503), respectively, for RFP resistance and

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Evaluation of the Performance of GenoType® MTBDRplusAssay for Rapid Detection of Multi-drug ResistantMycobacterium tuberculosisin Sputum Specimens

Cited by 2 publications

References 22 publications

Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Evaluation of the AdvanSure MDR-TB GenoBlot Assay for Detection of Rifampin and Isoniazid ResistantMycobacterium tuberculosisComplex in Respiratory Specimens

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