Evaluation of the peripapillary circulation in healthy and glaucoma eyes with scanning laser Doppler flowmetry

Hollo, G.; Greve, E. L.; Berg, Thomas; Vargha, P.

doi:10.1007/bf00212949

Cited by 39 publications

(49 citation statements)

References 15 publications

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“…These structural changes may eventually cause retinal microvessel loss and induce retinal capillary regression. 23 The significant correlation between the microvessel density and AL may also suggest that the global elongation may affect the retinal microvasculature. The stretching of the sclera, choroid, and retina caused by AL elongation may result in retinal and choroidal thinning.…”

Section: Discussionmentioning

confidence: 99%

“…6,19 However, Chueng et al 22 found no difference between myopic and normal eyes after correcting for field of view magnification. Hollo et al, 23 using the Heidelberg retina flowmeter, reported that capillary perfusion near the temporal edge of the optic disc was significantly decreased in healthy subjects and glaucoma patients with myopia. However, the tests and analyses of large retinal vessels and global flow may not reflect the early onset of retinal vascular alterations before the manifestation of obvious vasculopathies.…”

Section: Discussionmentioning

confidence: 99%

“…Decreases in blood flow in highly myopic eyes have been reported for both retrobulbar and retinal microvasculature. 5,24,26 Furthermore, using ultrawide fluorescein angiography, Hollo et al 23 identified a larger nonperfused zone in the far retinal periphery of highly myopic eyes. This nonperfused area may be caused by retinal stretching, which may further exacerbate peripheral retina thinning.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal vessels Laser Doppler velocimetry CRA blood flow decrease La Spina et al 25 2015 Retina vessels Dynamic Vessel Analyzer (DVA) Vessel diameter decrease Dimitrova et al 26 2002 Retrobulbar vessels Color Doppler imaging Central retinal vessel velocity decrease Li et al 19 2010 Retina large vessels Optic disc photographs Density decrease Azemin et al 6 2014 Retina large vessels NAVIS Lite Image Filing System Density decrease Lim et al 27 2011 Retina large vessels Retinal fundus photographs Retinal vessel density decrease Li et al 20 2011 Retina large vessels Fundus camera Retinal vessel density decrease Kaneko et al 28 2014 Retina large vessels Fluorescein angiography (FA) Perfusion area density decrease Hollo et al 23 1997 Peripapillary capillaries Heidelberg Retina Flowmeter Capillary perfusion density decrease CRA, central retinal artery.…”

Section: Present Study 2016mentioning

confidence: 99%

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Retinal Microvasculature Alteration in High Myopia

Wang

Jiang

et al. 2016

Invest. Ophthalmol. Vis. Sci.

129

100

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PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes.METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett's formula. Fractal analysis (box counting method, D box ) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS.The average density (D box ) of the superficial retinal annular zone (0.6-2.5 mm) microvessels was 1.741 6 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 6 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r ¼ À0.38 to À0.48; P < 0.05).CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Present Study 2016mentioning

confidence: 99%

See 2 more Smart Citations

Retinal Microvasculature Alteration in High Myopia

Wang

Jiang

et al. 2016

Invest. Ophthalmol. Vis. Sci.

129

100

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“…18,19 Other studies of glaucoma patients have shown abnormalities in blood rheology with increased blood viscosity and reduced erythrocyte deformability. 7,[20][21][22][23][24] In addition to the above clinical associations, a variety of experimental and clinical observations demonstrate circulatory aberrations of the anterior optic nerve, the peripapillary region, [25][26][27][28][29] the choroid, 27,30,31 and the retrobulbar vasculature [32][33][34][35][36][37][38][39][40] in eyes with GON. 33,[40][41][42][43] These apparent alterations in the circulation of the glaucomatous optic nerve may implicate dysfunction of vascular regulatory mechanisms.…”

Section: Glaucoma and Systemic Vascular Diseasementioning

confidence: 99%

Ischemic model of optic nerve injury

Cioffi

2006

American Journal of Ophthalmology

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Depth of Penetration of Scanning Laser Doppler Flowmetry in the Primate Optic Nerve

Wang

Cull²,

Cioffi³

2001

Arch Ophthalmol

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Objectives: To estimate the measuring depth of the blood flow and to establish the vascular contributions to these measurements with scanning laser Doppler flowmetry (SLDF) of the primate anterior optic nerve.Methods: Optic nerve blood flow in each eye of 8 monkeys was measured using SLDF before and following surgical occlusion of the central retinal artery (n=4) or posterior ciliary arteries (n = 4). The regional blood flow in both eyes was determined using a nonradioactive microsphere method.Results: The blood flow in the nerve fiber layer (NFL), including the prelaminar region, was measured with microspheres after central retinal artery occlusion; it was significantly reduced (−83%) with no significant change in the combined laminar and retrolaminar regions. The blood flow measured with SLDF had a 51% reduction. After posterior ciliary artery occlusion, the blood flow in the NFL was measured with microspheres and was not significantly affected (+2%); neither was that measured with SLDF (−12%). However, there was a 51% reduc-tion in the laminar and retrolaminar regions when microspheres were used. The mean±SD tissue thickness of the NFL was 359±16 µm and 353±54 µm in each group.Conclusions: Scanning laser Doppler flowmetry measures blood flow principally in the NFL of the anterior optic nerve, which is primarily supplied by the central retinal artery. Blood flow in the laminar and retrolaminar regions makes a small contribution to the SLDF measurement, with an NFL thickness between 300 and 400 µm.Clinical Relevance: Scanning laser Doppler flowmetry is used for the noninvasive evaluation of ocular microcirculation in diseases such as glaucoma. Because of the dual blood flow supply in the optic nerve and the limited penetration power of the laser, the instrument primarily measures the microcirculation on the surface of the optic nerve, which is largely supplied by the central retinal artery rather than the ciliary arteries.

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Evaluation of the peripapillary circulation in healthy and glaucoma eyes with scanning laser Doppler flowmetry

Cited by 39 publications

References 15 publications

Retinal Microvasculature Alteration in High Myopia

Retinal Microvasculature Alteration in High Myopia

Ischemic model of optic nerve injury

Depth of Penetration of Scanning Laser Doppler Flowmetry in the Primate Optic Nerve

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