Evaluation of the Pharmaceutical Properties and Value of Astragali Radix

Gong, Amy G. W.; Duan, Ran; Wang, Huaiyou; Kong, Xiangzhen; Dong, Tina Tingxia; Tsim, Karl Wah Keung; Chan, Kelvin

doi:10.3390/medicines5020046

Cited by 77 publications

(55 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As we all know, Astragalus membranaceus (AM) was originally described in the Sheng Nong's Herbal Classic which is the Classic of Herbal Medicine in ancient Evidence-Based Complementary and Alternative Medicine traditional Chinese medicine practice. It has a long history of medicinal use as one of the most important qi-tonifying herbs in traditional Chinese medicine [34]. Recently, AM is widely used in clinic treatment.…”

Section: Discussionmentioning

confidence: 99%

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

Liang

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Influenza is an acute respiratory infection disease caused by the influenza virus. At present, due to the high mutation rate of influenza virus, it is difficult for the existing antiviral drugs to play an effective antiviral effect continually, so it is urgent to develop a new anti-influenza drug. Recently, more and more studies have been conducted on the antiviral activity of Astragalus membranaceus, but the specific antiviral mechanism of this traditional Chinese medicine is not clear. In this study, the results proved that the Astragalus membranaceus injection showed obvious anti-influenza virus activity. It could improve the survival rate of Raw264.7 cells which were infected with influenza virus, while it improved the blocking effect of influenza virus on cell cycle after infection, increased the SOD activity, and reduced the MDA content. At the same time, the innate immunity was affected by regulating the expression of TLR3, TAK1, TBK1, IRF3, and IFN-β in the TLR3-mediated signaling pathway, thus exerting its antiviral effect in vitro.

show abstract

Section: Discussionmentioning

confidence: 99%

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

Liang

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…As we mentioned above, Astragali Radix is one of the main components of modified HGWD. In TCM theory, Astragali Radix has the effect of tonifying Qi, and Qi deficiency is considered a primary factor for the occurrence of neuropathic pain [36]. Pharmacology studies found that one of the main active components of Astragali Radix, Astragaloside IV (AS-IV), has neuroprotective effects and promotes neovascularization and is also indicated for the prevention of diabetes and its complications because of its decrease in lowing blood glucose and HbA1C levels and increase in insulin levels.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Zheng

Fan

Lin

et al. 2019

Journal of Diabetes Research

View full text Add to dashboard Cite

Painful diabetic peripheral neuropathy (pDPN) is a debilitating complication of diabetes. The aim of this retrospective study was to investigate the effectiveness of a Chinese herbal medicine regimen—the modified Huangqi Guizhi Wuwu Decoction (HGWD)—in the treatment of moderate-severe pDPN. The primary objective was to estimate the improvement in neuropathic pain severity. The secondary objective was to assess the response of common symptoms to the treatment. The change in patients’ blood glucose level during the whole treatment was also evaluated. By searching through our medical records of all the diabetic patients from January 2006 to January 2012, we identified and enrolled 30 moderate and severe pDPN patients in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed. The modified HGWD treatment was administered orally twice a day for 6 months. The numerical rating scale (NRS) level at month 6 was 2.57±2.30, significantly improved compared with the baseline level of 6.03±1.83 (P<0.05). The amelioration of 3 common symptoms, namely, limb pain, limb numbness, and insomnia, was evident, and the major response of common symptoms at month 6 including limb pain, insomnia, and limb coldness was significantly increased compared with the results at month 3 (P<0.05). Moreover, 2-hour postprandial blood glucose (2hPG) level decreased from 10.77±1.29 mmol/L at baseline to 9.66±0.60 mmol/L at month 6 (P<0.05). No serious adverse events occurred throughout the treatment period. The modified HGWD was effective in the treatment of moderate and severe pDPN and can thus be offered as a new alternative treatment option for pDPN patients who failed to respond to regular pharmaceutical therapies.

show abstract

“…Astragali Radix Bunge (also called as Huangqi in Chinese) has been diffusely utilised as an essential ingredient in over 200 Chinese herb prescriptions to treat weakness, anorexia, chronic fatigue, uterine bleeding, anemia, diarrhea and uterine prolapsed [6,7]. Currently, pharmacological experiments have showed that Astragali Radix possesses a wide variety of biological activities [8], including antioxidant, anti-aging, immunomodulation, anti-in ammation, antitumor, and anti-asthma pharmacological activities [9].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic Nephropathy

Tian¹,

Chen²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Diabetic nephropathy (DN), a unique complication of diabetes, could contribute to an increase in mortality. In this study, we predicted and proved the molecular pharmacological mechanism concerning the protective effects of Astragali Radix on DN. Methods The same potential target genes from Astragali Radix and DN were analyzed and constructed the protein interaction network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment-related major targets and signal pathways were performed. The drug-ingredients-target-disease network was visually built using Cytoscape 3.6.1. The beneficial pharmacological activities of quercetin from Astragali Radix were confirmed by CCK-8 assay, determination of antioxidant parameters and Western blotting analysis. Results There are 12 bioactive components from Astragali Radix and 56 same targets between Astragali Radix and DN. The GO analysis results showed that the biological processes mainly included protein homodimerization activity. KEGG analysis indicate that the screened targets were most closely linked to the mitogen-activated protein kinase (MAPK) signaling pathway. The drug-ingredients-target-disease network results revealed that the therapeutic effects of Astragali Radix mainly included oxidative stress, inflammatory reaction and apoptosis. During the verification process, quercetin from Astragali Radix could attenuate cytotoxicity, enhance catalase (CAT) and superoxide dismutase (SOD) activities and suppress MAPK signaling pathway. Conclusions In the current study, network pharmacology with experimental analysis predicted and proved the therapeutic function of Astragali Radix by improving antioxidant capacity and suppressing MAPK signaling pathway, these investigations could provide a new perspective for further exploration of Astragali Radix on DN treatment.

show abstract

Evaluation of the Pharmaceutical Properties and Value of Astragali Radix

Cited by 77 publications

References 89 publications

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic Nephropathy

Contact Info

Product

Resources

About