Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au 3 Ag 1 nanoparticles

Oluwole, David O.; Manoto, Sello Lebohang; Malabi, Rudzani; Maphanga, Charles; Ombinda‐Lemboumba, Saturnin; Mthunzi‐Kufa, Patience; Nyokong, Tebello

doi:10.1016/j.dyepig.2017.11.019

Cited by 17 publications

(5 citation statements)

References 44 publications

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“…S14b †) exhibit two characteristic peaks at 398.3 and 401.1 eV, attributed to NvC and N-H, respectively, indicating the existence of CvN linkages. 40 Moreover, the peak observed at 394.9 eV indicates the formation of an Mo-N moiety. 41 For C 1s, the spectrum of the Mo-HATN-COF is deconvoluted into three carbon species of C-C (284.9 eV), CvN (286.3 eV) and C-O (288.7 eV), confirming the existence of C-based frameworks (Fig.…”

Section: Resultsmentioning

confidence: 99%

Conductive metal-covalent organic frameworks as novel catalytic platforms for reduction of nitrate to ammonia

Huang,

Wang

2023

Green Chem.

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Section: Resultsmentioning

confidence: 99%

Conductive metal-covalent organic frameworks as novel catalytic platforms for reduction of nitrate to ammonia

Huang,

Wang

2023

Green Chem.

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“…Nanoscale materials such as nanoparticles offer several advantages to biosensors and this includes; signal amplifications, sensitivity, specificity, selectivity, stability, rapidity and cost effectiveness ( Farzin, et al, 2020 ; Oluwole et al, 2018 ). Detection of ultralow concentrations of biomarkers is impossible by using conventional Raman spectroscopy because the intensity of Raman scattering from the molecules is too low to be detected ( Devi et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Exploring optical spectroscopic techniques and nanomaterials for virus detection

Manoto

Elhussein

Malabi

et al. 2021

Saudi Journal of Biological Sciences

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Viral infections pose significant health challenges globally by affecting millions of people worldwide and consequently resulting in a negative impact on both socioeconomic development and health. Corona virus disease 2019 (COVID-19) is a clear example of how a virus can have a global impact in the society and has demonstrated the limitations of detection and diagnostic capabilities globally. Another virus which has posed serious threats to world health is the human immunodeficiency virus (HIV) which is a lentivirus of the retroviridae family responsible for causing acquired immunodeficiency syndrome (AIDS). Even though there has been a significant progress in the HIV biosensing over the past years, there is still a great need for the development of point of care (POC) biosensors that are affordable, robust, portable, easy to use and sensitive enough to provide accurate results to enable clinical decision making. The aim of this study was to present a proof of concept for detecting HIV-1 pseudoviruses by using anti-HIV1 gp41 antibodies as capturing antibodies. In our study, glass substrates were treated with a uniform layer of silane in order to immobilize HIV gp41 antibodies on their surfaces. Thereafter, the HIV pseudovirus was added to the treated substrates followed by addition of anti-HIV gp41 antibodies conjugated to selenium nanoparticle (SeNPs) and gold nanoclusters (AuNCs). The conjugation of SeNPs and AuNCs to anti-HIV gp41 antibodies was characterized using UV–vis spectroscopy, transmission electron microscopy (TEM) and zeta potential while the surface morphology was characterized by fluorescence microscopy, atomic force microscopy (AFM) and Raman spectroscopy. The UV–vis and zeta potential results showed that there was successful conjugation of SeNPs and AuNCs to anti-HIV gp41 antibodies and fluorescence microscopy showed that antibodies immobilized on glass substrates were able to capture intact HIV pseudoviruses. Furthermore, AFM also confirmed the capturing HIV pseudoviruses and we were able to differentiate between substrates with and without the HIV pseudoviruses. Raman spectroscopy confirmed the presence of biomolecules related to HIV and therefore this system has potential in HIV biosensing applications.

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“…Recently, several PS have gained prominence in clinical trials and applicatio The role of the PS in the success of PDT is indispensable due to their crucial f in the photosensitisation process. For optimum therapeutic activity, suitable PS pected to possess several characteristics, including good solubility in biological deep tissue penetration, minimal dark toxicity, intense Q-band absorption within t apeutic window (600 nm-800 nm), purity, photothermal stability, and high singlet quantum yields [18,[22][23][24]. However, there have been cases where pristine PS ex low purity, undesirable side effects (skin irritation), limited efficacy in deep tissue and reduced specificity, necessitating the need for PS with precise selectivity and ity, high purity, and deep tissue penetration [18].…”

Section: Photodynamic Therapy and Photosensitisermentioning

confidence: 99%

Multicomponent Crystals of Phthalocyanines–A Possibility of Fine-Tuning Properties

Oluwole

Báthori

2023

Colorants

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Phthalocyanines (Pcs) are 18-electron π-conjugated macrocyclic ring systems with proven activities in diverse fields, including pharmaceuticals and catalysis. These demonstrated activities are often alluded to as their fascinating photophysical and photochemical dispositions, which are usually dependent on their molecular structures. However, many of these molecules suffer from aggregation due to π–π stacking and have limited insolubility in hydrophilic media, which limits their extensive utilisation in pharmaceutical applications. This review will explore the possibility of fine-tuning the physicochemical properties of phthalocyanines when designed as multicomponent crystals. Among the proven and SMART approaches that have been shown to enhance drug solubility without altering the molecular structure is co-crystallisation. This protocol involves the design and formation of non-covalent interactions between two or more molecular entities to create a supramolecular assembly and subsequently afford multicomponent crystals (MCCs). A systematic review of the Cambridge Structural Database repository yielded several single and multicomponent crystals of Pcs; however, most of them were either salts or solvates, with only a few reports on their co-crystals.

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Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au 3 Ag 1 nanoparticles

Cited by 17 publications

References 44 publications

Conductive metal-covalent organic frameworks as novel catalytic platforms for reduction of nitrate to ammonia

Conductive metal-covalent organic frameworks as novel catalytic platforms for reduction of nitrate to ammonia

Exploring optical spectroscopic techniques and nanomaterials for virus detection

Multicomponent Crystals of Phthalocyanines–A Possibility of Fine-Tuning Properties

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