Polylactic-co-glycolic acid (PLGA) is the most popular biodegradable copolymers have several applications in the pharmaceuticals and biomedical industries, but degradation and stability of PLGA are major apprehensions. The aim of this study was to evaluate the impact of the Trivedi Effect ® on the physicochemical and thermal properties of PLGA using a number of analytical techniques. The PLGA powder sample was divided into two parts, one part of the test samples was considered as a control sample, whereas the other part of PLGA samples received the Trivedi Effect ® -Consciousness Energy Healing Treatment remotely by a well-known Biofield Energy Healer, Dahryn Trivedi and termed as a Biofield Energy Treated sample. The particle size values of the treated PLGA powder were significantly decreased by 48.08% (d 10 ), 40.08% (d 50 ), 33.78% (d 90 ), and 37.17% {D (4,3)} compared to the control sample. Hence, the specific surface area of the treated PLGA powder sample was significantly increased by 72.57% compared to the control sample. The PXRD diffractograms of the control and treated PLGA powder sample did not show sharp and intense peaks, indicated that both the samples were amorphous. The evaporation and melting temperature of the treated sample were slightly altered by 1.31% and -0.94%, respectively compared with the control sample. But, the latent heat of evaporation and latent heat of fusion of the treated PLGA sample were significantly increased by 6.91% and 116.91%, respectively compared with the control sample. The total weight loss was significantly decreased by 4.1%; however, the residue amount was 21.99% more in the treated PLGA sample compared to the control sample. The maximum thermal degradation temperature of the treated PLGA was altered by 2.37% compared with the control sample. From the results, it was established that the Trivedi Effect ® -Consciousness Energy Healing Treatment might introduce a new form of PLGA, which would show better solubility, dissolution rate, absorption, bioavailability, and thermal stability compared with the control PLGA. This the Trivedi Effect ® -Consciousness Energy Healing Treated PLGA would be a better choice for the pharmaceutical formulations, i.e., the drug like amoxicillin, simvastatin, minocycline, and vancomycin loaded PLGA nanoparticles and manufacturing of biomedical devices, i.e., grafts, surgical sealant films, sutures, prosthetic devices, implants, micro, and nanoparticles.