Evaluation of the platelet function analyzer (PFA-100®) vs. the thromboelastogram (TEG) in the parturient

Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples

“…The fibrinogen concentration was a main predictive variable of MA even in humans with combined vitamin K-dependent factor deficiencies. [16][17][18][19] In vitro adjustment of platelet concentration in human platelet-rich plasma samples impacted K, α angle, and particularly MA determined via TEG. 15 Platelet concentration has also been previously reported to impact TEM or TEG variables measured in blood samples from humans and other animals.…”

“…15 Maximum clot firmness is directly related to fibrinogen concentration in blood samples from humans with congenital fibrinogen deficiency and has been advocated as a surrogate marker for efficacy of fibrinogen replacement treatment. [17][18][19] Results of a study 16 of human platelet-rich plasma suggested that the critical platelet concentration necessary to cause K and MA to be outside reference ranges was < 66,000 platelets/µL. [16][17][18][19] In vitro adjustment of platelet concentration in human platelet-rich plasma samples impacted K, α angle, and particularly MA determined via TEG.…”

“…[16][17][18][19] In vitro adjustment of platelet concentration in human platelet-rich plasma samples impacted K, α angle, and particularly MA determined via TEG. 18 In the healthy dogs of the present study, platelet concentration correlated with CFT, α angle, and MCF, regardless of whether coagulation was initiated via the extrinsic or intrinsic pathway. In vitro adjustment of platelet concentration (by use of platelet depletion) in whole blood samples obtained from healthy humans and those with peripheral artery disease yielded a strong correlation between log platelet concentration and both K and MA.…”

The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets

“…Functional primary hemostasis was restored within hours of arousal from hibernation. In a thromboelastograph, the MA measures clot strength and correlates with platelet activity (3,5,17). The threefold increase in MA observed 2 h after the animals were aroused indicated that the platelets released back into the blood postarousal were still functional.…”

Investigation of the thrombin‐generating capacity, evaluated by thrombogram, and clot formation evaluated by thrombelastography of platelets stored in the blood bank for up to 7 days

“…Although the TEG provides additional information about the haemostatic system as compared to the thrombin generation assay, it should be noted that the ‘thrombus’ generation as measured by the TEG parameters included in the present study a more appropriate term would be clot generation, because it is an in vitro ‐generated clot and not a physiological thrombus. The reflection of thrombin generation by the TEG parameters may in part explain the clinical utility of the TEG as coagulation factor deficiency secondary to haemophilia, massive bleedings or thrombocytopenia/pathy may result in an impaired thrombin generation and consequently an impaired clot generation and reduced clot stability as evidenced by an abnormal TEG tracing [19–21]. This was demonstrated by Bassus et al .…”