Evaluation of the possible effect of inspiratory muscle training on inflammation markers and oxidative stress in childhood asthma

Gökçek, Özden; Yurdalan, Saadet Ufuk; Tuğay, Baki Umut; El, Çiğdem; Doğan, Serdar

doi:10.1007/s00431-023-05047-4

Cited by 2 publications

(7 citation statements)

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“…MEP: Data from five studies ( 13 , 18 , 19 , 21 , 22 ) involving 227 children were extracted for meta-analysis to assess the effects of IMT on MEP. Due to the high level of homogeneity ( I 2 = 92%), a random-effects model was employed.…”

Section: Resultsmentioning

confidence: 99%

“…While medication therapy has long been used for asthma control, non-pharmacological approaches, such as educational programs ( 26 ), self-management ( 27 ), breathing exercises ( 12 ), and physical training ( 28 ), have been highlighted as adjuvant therapies for children undergoing pharmacological asthma treatment and are widely used worldwide. IMT is a therapeutic modality aimed at strengthening respiratory muscles and has some applications in children with asthma ( 13 , 18 – 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…Out of the 2,112 potentially relevant studies, 241 duplicates and 1,853 articles were excluded based on reading of titles and abstracts. The remaining 18 publications were read in full, following which six randomized controlled trials (13,(18)(19)(20)(21)(22) were retained for the final analysis (Figure 1, Table 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…Respiratory muscle strength (MIP and MEP) MIP: Data from five studies (13,18,19,21,22) involving 227 children were extracted for meta-analysis to assess the effects of IMT on MIP. The training led to significant increase in MIP compared to control interventions (MD 25.36 cmH 2 O, 95% CI 2.47-48.26, P = 0.03; Figure 3).…”

Section: Outcome Measuresmentioning

confidence: 99%

“…Lista-Paz et al (17) reported that IMT can significantly increase maximum inspiratory pressure (MIP) in adults with asthma. While most recent systematic reviews and meta-analyses have predominantly focused on adults with asthma, several RCTs have been conducted on children with asthma (13,(18)(19)(20)(21)(22). Therefore, we systematically reviewed the available evidence from RCTs to assess the efficacy of inspiratory muscle training in strengthening the respiratory muscles in children with asthma.…”

Section: Introductionmentioning

confidence: 99%

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Effect of inspiratory muscle training in children with asthma: a systematic review and meta-analysis of randomized controlled trials

Xiang,

Luo,

Chen

et al. 2024

Front. Pediatr.

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BackgroundAsthma is a common chronic respiratory disease in children. Alongside pharmacological interventions, inspiratory muscle training (IMT) emerges as a complementary therapeutic approach for asthma management. However, the extent of its efficacy in pediatric populations remains uncertain when compared to its benefits in adults. This systematic review aims to evaluate the effectiveness of IMT with threshold loading in children with asthma.MethodsRandomized controlled trials (RCTs) evaluating the efficacy of inspiratory muscle training in pediatric asthma patients were identified through June 2023 across various literature databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAL), Web of Science, China Knowledge Resource Integrated Database (CNKI), Wei Pu Database, Wan Fang Database, and Chinese Biomedical Database (CBM). These trials compared inspiratory muscle training against sham inspiratory muscle training and conventional care. Eligible studies were assessed in terms of risk of bias and quality of evidence. Where feasible, data were pooled and subjected to meta-analysis, with results reported as mean differences (MDs) and 95% confidence intervals (CIs).ResultsSix trials involving 333 patients were included in the analysis. IMT demonstrated significant improvements in maximum inspiratory pressure (MIP) (MD 25.36, 95% CI 2.47–48.26, P = 0.03), maximum expiratory pressure (MEP) (MD 14.72, 95% CI 4.21–25.24, P = 0.006), forced vital capacity in percent predicted values [FVC(% pred)] (MD 3.90, 95% CI 1.86–5.93, P = 0.0002), forced expiratory volume in the first second in percent predicted values [FEV1(% pred)] (MD 4.96, 95% CI 2.60–7.32, P < 0.0001), ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) (MD 4.94, 95% CI 2.66–7.21, P < 0.0001), and asthma control test (ACT) (MD = 1.86, 95% CI: 0.96–2.75, P < 0.0001).ConclusionsFindings from randomized controlled trials indicate that inspiratory muscle training enhances respiratory muscle strength and pulmonary function in pediatric asthma patients.Systematic Review Registrationwww.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023449918, identifier: CRD42023449918.

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