Evaluation of the potential aphrodisiac activity of sesquiterpenoids from roots of Ferula huber-morathii Peşmen in male rats

Aydoğan, Fadime; Baykan, Şüra; Soliman, Gamal A.; Yusufoğlu, Hasan Soliman; Bedir, Erdal

doi:10.1016/j.jep.2020.112868

Cited by 13 publications

(10 citation statements)

References 55 publications

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“…2000 years ago. However, currently there is a greater danger lurking around Ferula drudeana growing in Anatolia perpetrated by the onslaught of publications appearing in various journals that the Ferula species growing in Anatolia has aphrodisiac qualities [63] and can help people that have erectile dysfunction problems [171][172][173]. If short-term commercial exploitation is unchecked, the very large-scale destruction of their roots certainly will drive many endemic The impact of these negative ecological and man-made factors, in addition to the over harvesting of the silphion plant, driven by short-term profit, definitely contributed to the extinction of this species.…”

Section: Discussionmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed.

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Section: Discussionmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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“…The results showed that only the chloroform extract and three compounds—deacetylkellerin, elaeochytrin-A, and ferutinin ( Figure 4 )—had a significant impact on stimulating sexual behaviors. Among these sesquiterpenoids, ferutinin was shown be the most effective aphrodisiac compound [ 14 ].…”

Section: Ferula Hubermentioning

confidence: 99%

“…In traditional Turkish medicine, several species of Ferula , such as the root and oleo gum resin of Ferula elaeochytris , Ferula communis , Ferula assa-foetida , and Ferula gummosa , have been used as aphrodisiacs to treat male sexual disorders. Ferula hermonis , also known as “zallouh” in the Middle East, is still used as a male aphrodisiac [ 14 ]. In Iranian traditional medicine, F. assa-foetida has also been used as an aphrodisiac [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Review of potential spermatogenic and aphrodisiac effects of the Ferula genus

Bagheri

Shieh

Ghalenoei

et al. 2023

Clin Exp Reprod Med

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Objective: Men’s sexual health plays an important role in male fertility and childbearing, as it is associated with factors such as sexual desire, healthy spermatogenesis, and erectile function. In various cultures, medicinal plants have been utilized to address male sexual issues, including infertility and erectile dysfunction. Despite recent advancements in medical science for treating male impotence, some men opt for herbal supplements as an alternative, given that numerous herbs have the potential to enhance male sexual performance. The Apiaceae family is one of the oldest plant families used for medicinal purposes. Ferula, a genus within this family, comprises approximately 170 different species worldwide. Members of this genus possess numerous therapeutic properties due to the presence of various compounds. This article aims to explore the potential impacts of Ferula plants on the male reproductive system. Methods: This review article was prepared by searching for terms including Ferula and “aphrodisiac,” Ferula and “spermatogenesis,” and Ferula and “male reproductive system.” Relevant information was gathered through electronic databases, including ISI Web of Knowledge, PubMed, and Google Scholar. Results: The findings indicated that relatively comprehensive studies have been conducted in this area, revealing that certain Ferula species have been employed in folk medicine to boost fertility and libido. Recent research has corroborated these effects. Conclusion: It is hoped that new aphrodisiac compounds with fewer side effects can be isolated from Ferula plants in the future.

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“…Rats designated for physical behavior analysis were evaluated for their behavior and housed under observation in a glass cage measuring 60×50×40 cm. To distinguish between groups, the animals were marked using picric acid with distinct markings assigned to each group [7][8] .…”

Section: Grouping Of Animalsmentioning

confidence: 99%

Butea Superba Rosb Extract Pharmacological Assessment for Aphrodisiac Effects

A. K.,

V. B.

2023

ijnrph

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This study conducted a thorough assessment of the aphrodisiac effects of Butea superba Roxb extract, using multiple parameters to evaluate its influence on male reproductive functions. At first, the researchers compared the androgenic activity to testosterone. They found that the ethanolic extracts group showed a significant increase in body weight, testes, epididymis, seminal vesicles weight, and testosterone levels. These findings indicate notable androgenic effects of the extracts, which may be linked to the plant's androgenic properties. An analysis of sexual performance showed a decrease in the time it took for mounting and initiating sexual activity, along with an increase in the frequency of mounting and sexual activity in the group that received ethanolic extracts. The results of the study suggest an improvement in sexual activity among male rats, as evidenced by an increase in the penile erection index. Through behavioral analysis, it was observed that the group treated with the extract displayed increased exploratory behavior and mounting scores. This indicates an overall improvement in response to sexual stimulus. The testis sections were examined histologically and showed a significant improvement in spermatogenesis, similar to the effects of testosterone. The extracts showed an improvement in spermatogenic activity that varied based on the dosage. In addition, the study revealed that the group treated with ethanolic extracts had higher testosterone levels compared to the control and testosterone groups. This suggests a possible boost in testosterone production.

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Evaluation of the potential aphrodisiac activity of sesquiterpenoids from roots of Ferula huber-morathii Peşmen in male rats

Cited by 13 publications

References 55 publications

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Review of potential spermatogenic and aphrodisiac effects of the Ferula genus

Butea Superba Rosb Extract Pharmacological Assessment for Aphrodisiac Effects

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