Evaluation of the potential impact and cost-effectiveness of respiratory syncytial virus (RSV) prevention strategies for infants in Argentina

Guiñazú, Gonzalo; Dvorkin, Julia; Mahmud, Sarwat; Baral, Ranju; Pecenka, Clint; Libster, Romina; Clark, Andrew; Caballero, Mauricio T.

doi:10.1016/j.vaccine.2024.126234

Vaccine

2024

DOI: 10.1016/j.vaccine.2024.126234

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Evaluation of the potential impact and cost-effectiveness of respiratory syncytial virus (RSV) prevention strategies for infants in Argentina

Gonzalo Guiñazú,

Julia Dvorkin,

Sarwat Mahmud

et al.

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Cited by 1 publication

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Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options

Riccò,

Abu-Raya,

Icardi

et al. 2024

Vaccines

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Background/Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly affecting young infants, older adults, and individuals with comorbidities. Methods: This document, developed as a consensus by an international group of experts affiliated with the World Association of Infectious Diseases and Immunological Disorders (WAidid), focuses on recent advancements in RSV prevention, highlighting the introduction of monoclonal antibodies (mAbs) and vaccines. Results: Historically, RSV treatment options were limited to supportive care and the monoclonal antibody palivizumab, which required multiple doses. Recent innovations have led to the development of long-acting mAbs, such as nirsevimab, which provide season-long protection with a single dose. Nirsevimab has shown high efficacy in preventing severe RSV-related lower respiratory tract infections (LRTIs) in infants, reducing hospitalizations and ICU admissions. Additionally, new vaccines, such as RSVpreF and RSVpreF3, target older adults and have demonstrated significant efficacy in preventing LRTIs in clinical trials. Maternal vaccination strategies also show promise in providing passive immunity to newborns, protecting them during the most vulnerable early months of life. This document further discusses the global burden of RSV, its economic impact, and the challenges of implementing these preventative strategies in different healthcare settings. Conclusions: The evidence supports the integration of both passive (mAbs) and active (vaccines) immunization approaches as effective tools to mitigate the public health impact of RSV. The combined use of these interventions could substantially reduce RSV-related morbidity and mortality across various age groups and populations, emphasizing the importance of widespread immunization efforts.

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Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options

Riccò,

Abu-Raya,

Icardi

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

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Evaluation of the potential impact and cost-effectiveness of respiratory syncytial virus (RSV) prevention strategies for infants in Argentina

Cited by 1 publication

References 26 publications

Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options

Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options

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