Evaluation of the potential modulator of bacterial resistance, acute toxicity and chemical composition of Schinopsis brasiliensis Engl.

Abstract

In Brazil's semi arid region, Schinopsis brasiliensis Engl. (Anacardiaceae) is used in traditional medicine, but little is known about its chemical, pharmacological and toxicological properties. In this study, the phytochemical and biological potential of the extract of S. brasiliensis (EESb) was evaluated. The main secondary metabolites in EESb were quantified by spectroscopy in the visible region. The minimum inhibitory concentration (MIC) of the extract, of antibiotics alone and of antibiotics combined with the extract were determined using microdilution method, and the acute toxicity was determined by in vivo tests. In microbiological testing, the EESb showed good antimicrobial activity against Staphylococcus aureus and, when combined with synthetic antibiotics, potentiated its activity by reducing the MIC values. In vivo studies showed low acute toxicity in rats treated with EESb. These results demonstrate the richness of the phenolic compounds in S. brasiliensis and its effectiveness as an antibacterial and in modulating activities of bacterial resistance. The probable low toxicity was also demonstrated.

Levantamento Etnofarmacológico/Etnobotânico De Plantas Medicinais Em Comunidade Rural No Município De São José Do Jacuípe-Ba

“…Com relação à avaliação de S. brasiliensis, há relatos na literatura sobre a atividade antioxidante de folhas e sementes [23][24][25][26] , atividade antimicrobiana da casca, casca da raiz, flores, vagens e sementes 24,[27][28][29] , toxicidade frente a Artemia salina das folhas e caules 30 e a atividade anticolinesterásica das sementes 24 . Há também relatos da determinação de compostos fenólicos totais e flavonoides totais em extratos de folhas dessa espécie 26 .…”

Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro

“…In this context, the Schinopsis brasiliensis Engl., is used in folk medicine to combat various diseases, including toothache, diarrhea, flu, and inflammations (Agra et al 2006, Albuquerque 2006, Albuquerque et al 2007, 2012. The bark of S. brasiliensis presents polyphenols, flavonoids, tannins, and saponins (Chaves et al 2015, Fernandes et al 2015 and a lot of compounds with biological activities have been isolated (Cardoso et al 2005, 2015, Santos et al 2017. In this way, Santos et al (2014) detected flavonoids and tannins in the hydroalcoholic extract of the bark of S. brasiliensis, along with the absence of toxicity.…”