Evaluation of the potential of chicoric acid as a natural food antioxidant

Zhu, Xueliang; Huang, Fenghong; Xiang, Xia; Fan, Min; Chen, Tingtao

doi:10.3892/etm.2018.6596

Cited by 18 publications

(17 citation statements)

References 35 publications

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“…The major active compounds in PCE are caftaric acid, polydatin, rutin, quercitrin, and resveratrol. The five active compounds are present in many natural plant extracts, and previous studies have demonstrated that they have anti-inflammatory and anti-oxidative properties [ 48 , 49 , 50 ]. Therefore, PCE may promote anti-oxidative activity in DED by recovering expression of anti-oxidant proteins such as HO-1, SOD-1, and GPx in hyperosmolar stressed HCECs.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model

et al. 2018

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Dry eyes are caused by highly increased osmolarity of tear film, inflammation, and apoptosis of the ocular surface. In this study, we investigated the effect of Polygonum cuspidatum (PCE) aqueous extract in in vivo and in vitro dry eye models. Dry eye was induced by excision of the lacrimal gland and hyperosmotic media. In vivo, oral administration of PCE in exorbital lacrimal gland-excised rats recovered tear volume and Mucin4 (MUC4) expression by inhibiting corneal irregularity and expression of inflammatory cytokines. In vitro, hyperosmotic media induced human corneal epithelial cell (HCEC) cytotoxicity though increased inflammation, apoptosis, and oxidative stress. PCE treatment significantly inhibited expression of cyclooxygenase-2 and inflammatory cytokines (interleukin-6 and tumor necrosis factor-α), and activation of NF-κB p65 in hyperosmolar stress-induced HCECs. Hyperosmolarity-induced increase in Bcl-2-associated X protein (BAX) expression and activation of cleaved poly (ADP-ribose) polymerase and caspase 3 were attenuated in a concentration-dependent manner by PCE. PCE treatment restored anti-oxidative proteins such as heme oxygenase-1 (HO-1), superoxide dismutase-1 (SOD-1), and glutathione peroxidase (GPx) in hyperosmolar stress-induced HCECs. These data demonstrate that PCE prevents adverse changes in the ocular surface and tear fluid through inhibition of hyperosmolar stress-induced inflammation, apoptosis, and oxidation, suggesting that PCE may have the potential to preserve eye health.

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Section: Discussionmentioning

confidence: 99%

The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model

et al. 2018

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“…It has been reported that chicoric acid possesses various functional properties including antioxidant, antivirus and immunoregulation. [28,29] Particularly, chicoric acid is a potent inhibitor of the integrase of the Type 1 human immunodeficiency virus (HIV-1). [30] Additionally, Lee and Scagel [28] indicated that chicoric acid helps a plant protect itself from insects and infection from viruses, bacteria, fungi, and nematodes and that it aids in wound healing in plants after mechanical damage.…”

Section: Rp-hplc Analysis Of Phenolic Compoundsmentioning

confidence: 99%

Antioxidant Sources from Leaves of Russian Dandelion

Molinu

Piluzza

Campesi

et al. 2019

Chemistry & Biodiversity

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Taraxacum kok‐saghyz (TKS) is a dandelion species native to Kazakhstan, Uzbekistan and north‐west China, considered as a promising alternative source of natural rubber from its roots. The aim of this study was to investigate the possible exploitation of TKS leaves, a rubber byproduct, as a source of phenolic compounds with antioxidant properties for potential applications in forage, nutraceutical and pharmacological fields. Two accessions (TKS016, TKS018) grown under Mediterranean conditions of Sardinia were evaluated at vegetative and flowering stages. The leaves of TKS018 had the highest antioxidant capacity (19.6 mmol trolox equivalent antioxidant capacity 100 g−1), total phenolic (106.4 g gallic acid equivalent kg−1), tannic phenolics (58.5 g gallic acid equivalent kg−1) and total flavonoid contents (22.9 g catechin equivalent kg−1). At both phenological stages, TKS016 showed significantly lower values than TKS018 in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), total phenolic and tannic phenolics. Six individual molecules were identified, namely chlorogenic, cryptochlorogenic, caffeic, sinapic, chicoric and 3,4‐dimethoxycinnamic acids. Chicoric (8.53–10.68 g kg−1 DW) and chlorogenic acids (4.18–7.04 g kg−1 DW) were the most abundant. TKS leaves represent a valuable source of chicoric acid with potential application as antioxidant to be used as herbal medicine and nutrition for production of healthy food/feed.

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“…Moreover, C. intybus leaves are specifically rich in chicoric acid as reported [ 63 , 67 ]. Chicoric acid, a caffeic acid derivative, has been also regarded as a nutraceutical with antioxidant and anti-inflammatory activities [ 68 , 69 ] as well as antioxidant effects, important for human health [ 70 ]. In addition to anti-inflammation [ 69 , 71 , 72 ] and antioxidation effects [ 73 , 74 ], the main benefits of chicoric acid also include antiviral [ 75 , 76 , 77 ], glucose and lipid homeostasis [ 78 , 79 ] and neuroprotection [ 80 ] activities.…”

Section: Resultsmentioning

confidence: 99%

First Insight into Nutraceutical Properties of Local Salento Cichorium intybus Varieties: NMR-Based Metabolomic Approach

Girelli

Serio

Accogli

et al. 2021

IJERPH

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Background: Plants of genus Cichorium are known for their therapeutic and nutraceutical properties determined by a wealth of phytochemical substances contained in the whole plant. The aim of this paper was to characterize the metabolic profiles of local Salento chicory (Cichorium intybus L.) varieties (“Bianca”, “Galatina”, “Leccese”, and “Otranto”) in order to describe their metabolites composition together with possible bioactivity and health beneficial properties. Methods: The investigation was performed by 1H-NMR spectroscopy and Multivariate Analysis (MVA), by which the metabolic profiles of the samples were easily obtained and compared. Results: The supervised Partial Least Squares Discriminant Analysis (PLS-DA) analysis showed as “Bianca” and “Galatina” samples grouped together separated by “Leccese” and “Otranto” varieties. A different content of free amino acids and organic acids was observed among the varieties. In particular a high content of cichoric and monocaffeoyl tartaric acid was observed for the “Leccese” variety. The presence of secondary metabolites adds significant interest in the investigation of Cichorium inthybus, as this vegetable may benefit human health when incorporated into the diet. Conclusions: The 1H-NMR (Nuclear Magnetic Resonance Spectroscopy) based characterization of Salento chicory varieties allowed us to determine the potential usefulness and nutraceutical properties of the product, also providing a method to guarantee its authenticity on a molecular scale.

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Evaluation of the potential of chicoric acid as a natural food antioxidant

Cited by 18 publications

References 35 publications

The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model

The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model

Antioxidant Sources from Leaves of Russian Dandelion

First Insight into Nutraceutical Properties of Local Salento Cichorium intybus Varieties: NMR-Based Metabolomic Approach

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