Evaluation of the potential of polymeric carriers based on chitosan‐grafted‐polyacrylonitrile in the formulation of drug delivery systems

Abstract

Graft copolymerization of chitosan with acrylonitrile (AN) was carried out by free radical polymerization using KMnO4 and oxalic acid as a combined redox initiator system. Graft copolymerization was confirmed by Fourier transform infrared spectra (FTIR), proton nuclear magnetic resonance spectra (1H‐NMR), thermal gravimetric analysis (TGA) measurements, and wide angle X‐ray diffraction (WAXD). In addition, further modification of the cyano groups of the grafted copolymers was performed by partial hydrolysis into carboxylic function groups with various extents. The extent of hydrolysis was monitored using FTIR spectroscopy. The potential of the hydrolyzed and unhydrolyzed grafted copolymers as polymeric carriers for drug delivery systems was extensively studied by preparation of tablets incorporated with methyl orange (MO) as a drug model. In vitro drug release was carried out in simulated gastric and intestinal conditions. The effects of grafting percentage (GP) and the extent of hydrolysis on the release kinetics were evaluated. Release continued up to 24 h for both hydrolyzed and unhydrolysed chitosan‐g‐PAN copolymers. The nature of drug transport through the polymer matrices was studied by comparing with power law or Kormeyer‐Peppas equation. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

Microstructure and magneto-dielectric properties of the chitosan/gelatin-YIG biocomposites

“…The crystalline phase obtained from the YIG powder was identified by comparing the diffractograms from the ICDD database (ICDD/PDF-70-0953), see Figure 3. One can observe in F sample an amorphous phase characteristic to the matrix polymer and this pattern follows those observed in the literature [18][19][20][21][22]. This behavior is present in all composites, see FY 25 and FY 50 ( Figure 3).…”

Preparation and characterization of chitosan-grafted-poly(2-amino-4,5-pentamethylene-thiophene-3-carboxylic acid N′-acryloyl-hydrazide) chelating resin for removal of Cu(II), Co(II) and Ni(II) metal ions from aqueous solutions

“…This lowering in crystallinity can be attributed to the insertion of the grafted chains onto the chitosan backbone may led to breaking the hydrogen bonding in the chitosan polysaccharide structure resulting in an amorphous structure. Similar discussions for the deformation of crystal structure had been explained in previous references [15,21].…”

“…Therefore, a series of chemical modifications on chitosan have been conducted such as nitration, phosphorylation and sulphation [14,15]. On the other hand, the graft copolymerization is expected to be one of the most promising approaches for molecular designs leading to novel types of hybrid materials which can introduce desired properties and enlarge the application fields of chitosan [16].…”

Novel water-soluble chitosan derivative prepared by graft polymerization of dicyandiamide: synthesis, characterisation, and its antibacterial property

“…Studies on the graft copolymerization of chitosan with various vinyl monomers have been conducted with different initiating systems and different mechanisms. Several studies on the graft copolymerization onto CS with a wide range of initiator systems to initiate graft copolymerization onto CS have been reported [4,[10][11][12][13][14][15][16][17][18][19][20]. Ammonium persulphate (APS), ceric ammonium nitrate (CAN) and potassium persulphate (KPS) were proven to be effective as initiator were used in our study.…”