Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis

Abstract

Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive. Therefore, the aim of this study was to evaluate its potential sensitization systematically using meta-analysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria. In ASA test, odds ratio of behavior changes was 4.33 (1.62, 11.60), showing significant changes after CGA treatment (P = 0.004). Serum IgG, serum histamine, PLN cellularity, and IgG1 AFCs were significantly enhanced after CGA treatment (P < 0.05). Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices.

Effect of decaffeinated coffee-enriched chlorogenic acid on blood glucose levels in healthy controls: A systematic review

“…[789] Based on recent findings, there are many biological properties for CGA such as antibacterial, antioxidant, anticarcinogenic, and especially blood glucose lowering effect in animals. [8101112] Several mechanisms have been suggested for the effects of CGA on glucose metabolism. One of these mechanisms is inhibition of α-glucosidase and glucose-6-phosphate translocase 1, which leads to elevated glucagon-like peptide 1 (GLP-1) secretion and delayed intestinal glucose uptake, eventually resulting in altered blood glucose level.…”

Oral ingestion of dandelion juice for vesicular hand eczema: Treatment or challenge?

“…9,10 Chlorogenic acid has been incriminated as a cause of immediate hypersensitivity, but not contact allergy according to the literature. 11 The genera Taraxacum and Lactuca both belong to the subfamily Cichorioideae, tribe Lactuceae. Based on the results in the control patient, who was allergic to Compositae, the dandelion juice most probably contains sesquiterpene lactones, and another possible explanation of the reaction in the fourth patient is that she had a weak/incipient sensitization to either related sesquiterpene lactones or other compounds found both in dandelion and lettuce latex.…”

“…Ferulic acid, although detected in minute amounts in the leaf extract of two Mexican tomato cultivars studied, has been reported as a contact allergen in propolis . Chlorogenic acid has been incriminated as a cause of immediate hypersensitivity, but not contact allergy according to the literature …”

Forsythoside A and Forsythoside B Contribute to Shuanghuanglian Injection-Induced Pseudoallergic Reactions through the RhoA/ROCK Signaling Pathway

“…In recent years, several studies have been performed to identify the chief componential culprits contributing to SHLI-induced hypersensitivity reactions. Chlorogenic acid [26,27] and baicalin [28,29], contained in SHLI, are commonly reported as being the responsible constituents triggering allergic reactions, due to their antigenic properties. However, based on clinical data, most adverse reactions to SHLI occur at the first exposure [6,30], which might suggest that these reactions are unlikely to be immune-mediated.…”