Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer

Schippinger, Walter; Regitnig, Peter; Dandachi, Nadia; Wernecke, Klaus‐Dieter; Bauernhofer, Thomas; Samonigg, Hellmut; Moinfar, Farid

doi:10.1007/s00428-006-0213-6

Cited by 69 publications

(63 citation statements)

References 19 publications

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“…Our results are consistent with those presented by Shippinger, who found the mean survival time after recurrence to be significantly longer in AR (+) patients (21.89 months vs. 11.99 months) [34]. Correno did not observe any statistically significant association between AR expression and local recurrences [35], which, however, has not been confirmed in our study.…”

Section: Discussionsupporting

confidence: 87%

Androgen receptors as a prognostic and predictive factor in breast cancer.

Agrawal

Jeleń²,

Grzebieniak³

et al. 2008

Folia Histochem Cytobiol.

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Many theoretical and experimental models indicate that androgen receptors can play an important role as prognostic factors in breast cancer. The aim of this study was to evaluate the correlations between the presence of androgen receptors on cancer cells and other selected prognostic and predictive factors with established clinical significance in women with breast cancer after radical surgical treatment. 488 adult females were included in the study, who underwent primary radical surgery for breast cancer. 428 patients (87.7%) had Patey's conservative radical mastectomy and 60 (12.3%) Halsted's radical mastectomy. The mean age at operation was 54.3, ranging from 32 to 79. The mean length of hospitalization was 7.2 days for the patients after Patey's mastectomy and 9.8 days for those after Halsted's mastectomy. The androgen receptor is the most frequently detected steroid receptor on breast cancer cells. Therapeutic efficacy of adjuvant hormone therapy was higher in the group of androgen receptor-positive patients than in androgen receptor-negative ones. The prognosis for androgen receptor-positive patients who underwent adjuvant hormone therapy was better than for those androgen receptor-positive patients who did not receive hormone therapy after primary radical surgery for breast cancer. Assessment of androgen receptor levels on cancer cells should become a routine procedure with patients undergoing primary radical surgery for breast cancer, as it seems to be an important predictive factor.

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Section: Discussionsupporting

confidence: 87%

Androgen receptors as a prognostic and predictive factor in breast cancer.

Agrawal

Jeleń²,

Grzebieniak³

et al. 2008

Folia Histochem Cytobiol.

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“…Some data indicate that AR is more abundant in malignant mammary tissue than ERa (Lea et al 1989, Isola 1993, Schippinger et al 2006, Hanley et al 2008, Park et al 2010. Androgen treatment has yielded conflicting proliferation results in classic breast cancer cell lines, which indicates that the mechanistic role of AR in breast tumors is more complex (Birrell et al 1995).…”

Section: Ar-positive Breast Cancermentioning

confidence: 99%

Influence of stromal–epithelial interactions on androgen action

Nieto

Rider

Cramer

2014

Endocrine-Related Cancer

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Androgen receptor (AR) signaling is vital to the development and function of the prostate and is a key pathway in prostate cancer. AR is differentially expressed in the stroma and epithelium, with both paracrine and autocrine control throughout the prostate. Stromalepithelial interactions within the prostate are commonly dependent on AR signaling and expression. Alterations in these pathways can promote tumorigenesis. AR is also expressed in normal and malignant mammary tissues. Emerging data indicate a role for AR in certain subtypes of breast cancer that has the potential to be exploited therapeutically. The aim of this review is to highlight the importance of these interactions in normal development and tumorigenesis, with a focus on the prostate and breast.

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“…Few groups have studied membrane-associated or cytoplasmic signaling complexes containing both ERα and PR-B or AR [71,72]. However, AR is frequently (70%) expressed in metastatic breast cancer [73], and expression of functional AR defines a sub-set of ER/PR-negative breast cancers [74]. These studies suggest that it will be important to target SRs that may substitute for ERα in the activation of c-Src-dependent mitogenic signaling cascades.…”

Section: Integration Of Rapid Signaling and Nuclear Sr Actionsmentioning

confidence: 99%

Integration of progesterone receptor action with rapid signaling events in breast cancer models

Lange

2008

The Journal of Steroid Biochemistry and Molecular Biology

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Recent discoveries suggest that several protein kinases are rapidly activated in response to ligand binding to cytoplasmic steroid hormone receptors (SRs), including progesterone receptors (PRs). Thus, PRs act as ligand-activated transcription factor "sensors" for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast. Induction of rapid signaling upon progestin-binding to PR-B provides a means to ensure that receptors and co-regulators are appropriately phosphorylated as part of optimal transcription complexes. Alternatively, PR-B activated kinase cascades provide additional avenues for progestin-regulated gene expression independent of PR nuclear action. Herein, an overview of progesterone/PR and signaling cross-talk in breast cancer models is provided. Kinases are emerging as key mediators of PR action. Cross-talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues, and is suspected to contribute to cancer biology.

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Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer

Cited by 69 publications

References 19 publications

Androgen receptors as a prognostic and predictive factor in breast cancer.

Androgen receptors as a prognostic and predictive factor in breast cancer.

Influence of stromal–epithelial interactions on androgen action

Integration of progesterone receptor action with rapid signaling events in breast cancer models

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