Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation

Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models

“…Additionally, more recent research carried out on rabbit foetuses by Jimenez-Bravo et al (2016) showed that PPTis capable of modifying some biochemical parameters during ischemia in utero and during ensuing reperfusion. For example, the levels https://doi.org/10.17221/43/2021-VETMED of foetal glucose were lower in foetuses without treatment in comparison to those foetuses that received PPT possibly as a result of preserving energy metabolism under hypoxic conditions.…”

“…The mortality rate for human neonates who have experienced asphyxia is approximately 45% while 25% of those who survive have changes on physiological and metabolic levels as well as to the central nervous system (CNS), which is why they exhibit neurological disorders that can range from cerebral palsy, encephalopathy, motor disorders, as well as seizures or cognitive disorders of varying severity, such as attention deficit, hyperactivity, mental retardation and neuropsychiatric syndromes (Boskabadi et al 2015;Capani et al 2016). Therefore, because asphyxia represents one of the main causes of perinatal mortality worldwide and is an important factor in serious neurological in neonates and foetuses, various experimental studies have been carried out in recent years (Fanos et al 2014;Jimenez-Bravo et al 2016;Laptook et al 2017) in order to create protocols that will facilitate the identification, reduction and prevention of physio-metabolic alterations and brain damage caused by perinatal asphyxia. Hence, the objective of this review is to analyse the advantages and disadvantages of the application of various treatments and therapeutic protocols commonly used for the prevention and treatment of perinatal asphyxia in human neonates and in different animal models that have been used in human medicine.…”

Seguimiento de fibras de materia blanca mediante convolución esférica restringida por resonancia magnética para la evaluación empírica del pirofosfato de tiamina en la disminución del daño neuronal estructural neonatal

“…Valenzuela et al [42] demostraron limitación del daño neuronal mediante la aplicación de PPT en ratas neonatas sometidas a Isquemia. En un estudio reciente, se demostró que la administración del PPT en conejas gestantes, evitó cambios gasométricos en los fetos sometidos a un proceso de I/R [43].…”

“…Mediante la visualización ultrasónica en tiempo real de los movimientos de los fetos, el corazón, y los vasos sanguíneos, así como las variaciones en la intensidad del eco retornado como una gráfica simple de las variaciones de la amplitud en el tiempo, se determinó la viabilidad y cantidad de los fetos. Corroborada la gestación y el número de fetos, se asignó en forma aleatoria a uno de dos grupos: a) Grupo control: dos conejas b) Grupo experimental: 10 conejas El grupo experimental fue dividido en dos conjuntos asignados de manera aleatoria y cegado a la administración de una dosis de cocarboxilasa a 40mg/kg [43] intravascular vs solución salina inyectable. La administración del medicamento o el placebo, fue cegado al grupo de investigación por el Laboratorio Manuell S.A. Ciudad de México, México.…”