Evaluation of the proteomic profile in saliva of brazilian home-based and informal workers

Araujo, Alda Neis Miranda; Furtado, Danielle Zildeana Sousa; Silva, Heron Dominguez Torres; Olympio, Kelly Polido Kaneshiro; Assunção, Nilson Antônio

doi:10.1289/isee.2021.p-060

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“…In 2019, a proteomic study based on the saliva of informal and home-based jewelry welders showed that exposure to PTEs (As, Cr, Cd, Cu, Mn, Ni, Pb, and Zn) modulates protein expression. According to the results, welders may have immunity problems and their genes were overrepresented in metabolic processes, catalytic activity, stimulus-response, response to toxic substances, metabolism activity, apoptosis, changes in the cell cycle, and stress response 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Is chemical exposure present in informal work associated with Sars-CoV-2 infection?

et al. 2023

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OBJECTIVE: To compare the incidence of Covid-19 symptoms between informal home-based workers and a control group and to assess the association of these cases with blood elements concentrations and other relevant risk factors for Sars-Cov-2 infection. METHODS: Welders chemically exposed to potentially toxic elements (PTEs) (n = 26) and control participants (n = 25) answered questionnaires on adherence to social distancing and signs and symptoms of the disease for five months during the Covid-19 pandemic. After follow-up, Covid-19 serology tests were performed on a subsample of 12 chemically exposed workers and 20 control participants. Before the pandemic, PTE concentrations in blood (As, Mn, Ni, Cd, Hg, Sb, Sn, Cu, Zn, and Pb) were measured by ICP-MS. RESULTS: The chemically exposed group had higher lead and cadmium levels in blood (p < 0.01). The control group presented lower adherence to social distancing (p = 0.016). Although not significant, welders had a 74% greater chance of having at least one Covid-19 symptom compared with control participants, but their adherence to social distancing decreased this chance by 20%. The use of taxis for transportation was a risk factor significantly associated with Covid-19 symptoms. CONCLUSION: The lower adherence to social distancing among the control group greatly influences the development of Covid-19. The literature lacks data linking exposure to PTEs and Sars-Cov-2 infection and/or severity. In this study, despite chemical exposure, working from home may have protected welders against Covid-19, considering that they maintained greater social distancing than control participants.

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Section: Introductionmentioning

confidence: 99%