Evaluation of the pulmonary effects of wood smoke in guinea pigs by repeated CO2 challenges

Wong, King-Lit; Stock, Maryanne F.; Malek, Dolores E.; Alarie, Y.

doi:10.1016/0041-008x(84)90077-2

Cited by 23 publications

(10 citation statements)

References 25 publications

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“…The results obtained indicate that MIC induced severe airways obstruction and that recovery from the pulmonary effects of MIC is very slow-much slower than recovery following pulmonary irritation induced by sulfuric acid (18), toluene diisocyanate (TDI) (20), or smoke from wood (21). The recovery from MIC is similar to that following exposure to smoke from polyvinyl chloride (22 figure).…”

Section: Discussionsupporting

confidence: 59%

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Alarie¹,

Ferguson²,

Stock³

et al. 1987

Environ Health Perspect

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Methyl isocyanate (MIC) was evaluated for sensory and pulmonary irritation in mice. MIC was found to be both a potent sensory and pulmonary irritant in this species. From these results, a safe level of exposure for a period of 8 hr was estimated to be about 0.02 ppm for humans. Guinea pigs were also exposed to MIC for a single 3-hr exposure at a concentration of 37 ppm. During exposure to MIC, coughing was observed in all animals. Pulmonary function was evaluated immediately following exposure and intermittently on the next 35 days using CO2 challenges and flow-volume loops. Highly abnormal responses to CO2 were observed immediately after exposure in all animals. Six of the eight animals exposed to MIC died. In the two survivors, an apparent recovery was seen during the 5 days following exposure, but a worsening effect was observed at days 21 and 28, with a partial recovery at day 35. The data clearly demonstrated that the primary pulmonary effect of MIC was one of airways obstruction. Oxygen uptake and carbon dioxide output were also measured in the guinea pigs following exposure to MIC. No evidence of a cyanidelike effect was observed, in contrast to a severe depression of oxygen uptake following exposure to hydrogen cyanide.

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Section: Discussionsupporting

confidence: 59%

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Alarie¹,

Ferguson²,

Stock³

et al. 1987

Environ Health Perspect

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“…Similar results have been reported in guinea pigs up to 1 year after a single 19-ppm exposure (Ferguson and Alarie, 1991). Carbon dioxide challenge has also been used to enhance the detection of lung injury produced by sulfuric acid mist (Wong and Alarie, 1982), quartz dust (Chvalova et al, 1974), cotton dust (Ellakkani et al, 1984), and wood smoke (Wong et al, 1984). Furthermore, decreases in CO 2 responsiveness in the rat also have been detected after lung surgical manipulation (insertion of a pleural catheter), as well as with increasing animal age .…”

Section: Methods For Enhancing the Sensitivity Of Ventilatory Testssupporting

confidence: 74%

Methods, Measurements, and Interpretation of Animal Lung Function in Health and Disease

Tepper¹,

Costa²

2015

Comparative Biology of the Normal Lung

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“…In addition to the common rodent models (rats and mice) (Barrett et al 2006;Dubick et al 2002;Ho and Kou 2002;Huang et al 2006;Ischiropoulos et al 1994;Liang et al 1988;Matthew et al 2001;Mumford et al 1990;Reed et al 2006;Samuelsen et al 2008;Tesfaigzi et al 2002Tesfaigzi et al , 2005, other well-known species used in these studies include guinea pigs Hsu et al 1998aHsu et al , 1998bHsu et al , 2000Hsu and Kou 2001;Kou and Lai 1994;Kou et al 1995Kou et al , 1997Kou et al , 1999Lai and Kou 1998a, 1998cLin et al 2001;Wang et al 1996;Wong et al 1984) and rabbits (Bhattacharyya et al 1998;Fick et al 1984;Loke et al 1984;Thorning et al 1982). Other groups have taken advantage of less known species such as pigs/piglets (Jeng et al 2003;Steinberg et al 2005), dogs (Brizio-Molteni et al 1984;Clark et al 1990;Nieman et al 1980;Nieman et al 1989Nieman et al , 1995, and sheep (Hubbard et al 1991;Park et al 2004).…”

Section: Animal Modelsmentioning

confidence: 98%

“…Extrapulmonary assessments have included effects on the cardiovascular system (Brizio-Molteni et al 1984), adjuvant activity (Samuelsen et al 2008 (Bhattacharyya et al 1998;Liang et al 1988;Mumford et al 1990). In addition, these parameters were assessed using a variety of techniques including surfactant supplementation (Jeng et al 2003), footpad injections for adjuvant analysis (Samuelsen et al 2008), whole-body plethysmography (Wong et al 1984) for assessment of pulmonary functions, tracheal and rat lung explants (Bhattacharyya et al 1998;Iba et al 2006), and histopathological assessments (Hubbard et al 1991;Tesfaigzi et al 2002;Thorning et al 1982). In addition to these parameters, others were discussed in the IBSHE workgroup, as well as the availability of research systems to properly assess the health outcomes of these exposures.…”

Section: Parameters Assayedmentioning

confidence: 99%

Biomass smoke exposures: toxicology and animal study design

Migliaccio

Mauderly

2009

Inhalation Toxicology

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The International Biomass Smoke Health Effects (IBSHE) conference was convened in Missoula, MT, to define our current knowledge of smoke exposure and the potential health effects. In an effort to ascertain the relative health effects of an exposure to biomass smoke, numerous studies have utilized either animal or in vitro systems. A wide variety of systems that have been employed ranged from more mainstream animal models (i.e., rodents) and transformed cell lines to less common animal (piglets and dogs) and explant models. The Toxicology and Animal Study Design Workgroup at IBSHE was tasked with an analysis of the use of animal models in the assessment of the health effects of biomass smoke exposure. The present article contains a mini-review of models utilized historically, in addition to the adverse health effects assessed, and an overview of the discussion within the breakout session. The most common question that arose in discussions at the IBSHE conference was from local and federal health departments: What level of smoke is unhealthy? The present workgroup determined categories of exposure, common health concerns, and the availability of animal models to answer key health questions.

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Evaluation of the pulmonary effects of wood smoke in guinea pigs by repeated CO2 challenges

Cited by 23 publications

References 25 publications

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Methods, Measurements, and Interpretation of Animal Lung Function in Health and Disease

Biomass smoke exposures: toxicology and animal study design

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