Safety performance improvements in an organization can increase its resistance or robustness and lower risk of accidents. Safety management practices are the policies, strategies, procedures, and activities implemented or followed by the management of an organization targeting safety of their employees. It is the important element that will approve an effective management of safety organization. There are more than 50 cases involved each year by negligence of driver in Port Pasir Gudang, and death case reported at Port Pulau Pinang. Meanwhile, there is death case reported because crushed by container at Port Klang Westport. Thus, this study want to investigate the relationship between safety management practices and safety performance in port industries, focus on Port Tanjung Pelepas and Port Pasir Gudang at Johor, Malaysia. The data collected by using questionnaire and distributed to 300 employees but only 146 were collected. This study found that safety management practices are important predictor of safety performance in organization.