Evaluation of the reaction kinetics of CORTOSSTM, a thermoset cortical bone void filler

Pomrink, G.J.; DiCicco, Michael; Clineff, Ted D.; Erbe, Erik M.

doi:10.1016/s0142-9612(02)00443-x

Cited by 33 publications

(21 citation statements)

References 10 publications

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“…High final monomer conversion is required for good physical/mechanical composite properties in addition to the low risk of toxic monomer leaching [49,50]. The final monomer conversion of Cortoss in the current study was lower than that previously obtained (80 %) using differential scanning calorimetry (DSC) [51]. DSC, however, has given higher final conversion compared to FTIR in other studies [52,53].…”

Section: Polymerization Of Freshly Prepared Materialscontrasting

confidence: 74%

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

Panpisut

Main

Khan

et al. 2018

Preprint

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14 Purpose: The aim was to determine effects of diluent monomer and monocalcium 15 phosphate monohydrate (MCPM) on polymerization kinetics and volumetric stability, 16 apatite precipitation, strontium release and fatigue of novel dual-paste composites for 17 vertebroplasty. 18 Materials and methods: Polypropylene (PPGDMA) or triethylene (TEGDMA) glycol 19 dimethacrylates (25 wt%) diluents were combined with urethane dimethacrylate (70 20 wt%) and hydroxyethyl methacrylate (5 wt%). 70 wt% filler containing glass particles, 21 glass fibers (20 wt%) and polylysine (5 wt%) was added. Benzoyl peroxide and MCPM 22 (10 or 20 wt%) or N-tolyglycine glycidyl methacrylate and tristrontium phosphate (15 23 wt%) were included to give initiator or activator pastes. Commercial PMMA (Simplex) 24 and bone composite (Cortoss) were used for comparison.

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Section: Polymerization Of Freshly Prepared Materialscontrasting

confidence: 74%

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

Panpisut

Main

Khan

et al. 2018

Preprint

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“…Bioactive materials are gaining greater importance and exhibit superior characteristics to classic allografts in biomechanical studies and small clinical short-term settings, 35,38 but they still have to stand the test of time. Osteoconductive bioresorbable materials, tissue engineering, 36,37,40,41 osteoinduction by growth factors, and gene therapy 12,17,31 are only recently gaining access in larger clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Long-term results following titanium cranioplasty of large skull defects

Čabraja¹,

Klein

Lehmann³

2009

FOC

269

171

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Object Decompressive craniectomy is an established procedure to lower intracranial pressure. Therefore, cranioplasty remains a necessity in neurosurgery as well. If the patient's own bone flap is not available, the surgeon can choose between various alloplast grafts. A review of the literature proves that 4–13.8% of polymethylmethacrylate plates and 2.6–10% of hydroxyapatite-based implants require replacement. In this retrospective study of large skull defects, the authors compared computer-assisted design/computer-assisted modeled (CAD/CAM) titanium implants for cranioplasty with other frequently used materials described in literature. Methods Twenty-six patients underwent cranioplasty with CAD/CAM titanium implants (mean diameter 112 mm). With the aid of visual analog scales, the patients' pain and cosmesis were evaluated 6–12 years (mean 8.1 years) after insertion of the implants. Results None of the implants had to be removed. Of all patients, 68% declared their outcomes as excellent, 24% as good, 0.8% as fair, and 0% as poor. There was no resulting pain in 84% of the patients, and 88% were satisfied with the cosmetic result, noting > 75 mm on the visual analog scale of cosmesis. All patients would have chosen cranioplasty again, stating an improvement in their quality of life by the calvarial reconstruction. Nevertheless, follow-up images obtained in 4 patients undergoing removal of meningiomas was only suboptimal. Conclusions With the aid of CAD technology, all currently used alloplastic materials are suited even for large skull defect cranioplasty. Analysis of the authors' data and the literature shows that cranioplasty with CAD/CAM titanium implants provides the lowest rate of complications, reasonable costs, and acceptable postoperative imaging. Polymethylmethacrylate is suited for primary cranioplasty or for long-term follow-up imaging of tumors. Titanium implants seem to be the material of choice for secondary cranioplasty of large skull defects resulting from decompressive craniectomy after trauma or infarction. Expensive HA-based ceramics show no obvious advantage over titanium or PMMA.

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“…[2] Many synthetic substitutions of dura and bone are often used for reconstruction of the skull base; unfortunately, these methods bear significant disadvantages and can induce chronic inflammation, carry a high risk of infection, and are inferior to the biological sources in terms of strength and sealing quality,[3839] [with the probable exception of some materials, such as titanium mashes and CortossTM (Orthovita®, Malvern, USA), which prove to have more strength than the thin split thickness calvarial bone]. [40–42]…”

Section: Disadvantagementioning

confidence: 99%

Split calvarial bone graft for the reconstruction of skull defects

Agrawal

Garg

2011

J Surg Tech Case Report

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Cranioplasty is a common, but formidable surgical procedure for neurosurgeons, in patients with scalp and / or calvarial defects. This procedure can be simple or complex. The main objectives of cranioplasty are: To achieve primary wound healing, obliterate dead space, and seal off sterile cranial areas from contaminated oronasal cavities, to restore the normal barriers protecting the intracranial structures (together with a satisfactory cosmetic result) and obtain a permanent or very durable reconstruction, using biologically inert materials, and also to restore the aesthetics. The greatest problem is selecting the optimum material for repair of the cranial defect. Many synthetic substitutions of the dura and bone are often used for reconstruction of the skull base; unfortunately, these methods bear significant disadvantages and can induce chronic inflammation, carry a high risk of infection, and are inferior to biological sources in terms of strength and sealing quality [with the exception of some materials, such as titanium mashes and CortossTM (Orthovita®, Malvern, USA), which are seen to have more strength than the thin split thickness calvarial bone]. The primary aim of this article is to review the basic principles to use the split calvarial graft for the reconstruction of the skull defect.

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Evaluation of the reaction kinetics of CORTOSSTM, a thermoset cortical bone void filler

Cited by 33 publications

References 10 publications

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

Long-term results following titanium cranioplasty of large skull defects

Split calvarial bone graft for the reconstruction of skull defects

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