Evaluation of the reaction of cereal cultivars to viruses as a preliminary step in plant health management

Stoev, A.

doi:10.1016/b978-0-12-821629-3.00006-3

Cited by 2 publications

(2 citation statements)

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“…2 At present, there are not many effective and satisfactory anti-plant-virus agents in practical application, especially therapeutic agents. 3 The control effects of the reported agents in field application are mostly below 60%. 4 Facing the harm of plant viruses in agricultural production, it is necessary to develop new and high-efficiency anti-plant-virus drugs.…”

Section: ■ Introductionmentioning

confidence: 98%

“…Plant virus disease pandemics and epidemics were estimated to have a global economic impact of > US $30 billion annually . At present, there are not many effective and satisfactory anti-plant-virus agents in practical application, especially therapeutic agents . The control effects of the reported agents in field application are mostly below 60% .…”

Section: Introductionmentioning

confidence: 99%

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Discovery of Aldisine and Its Derivatives as Novel Antiviral, Larvicidal, and Antiphytopathogenic-Fungus Agents

Yang

Hao

et al. 2022

J. Agric. Food Chem.

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Based on the widespread use of hydrogen bonds in drug design, a series of aldisine derivatives containing oxime, oxime ether, and hydrazone moieties were designed and synthesized, and their antiviral, larvicidal, and fungicidal activities were evaluated for the first time. The bioassay results showed that most of these derivatives were active against tobacco mosaic virus (TMV). Hydrazone derivative 12 showed in vivo inactivation, curative, and protection activities of 52 ± 4, 49 ± 1, and 52 ± 3% at 500 mg/L, which are comparable to that of the commercial antiviral drug ningnanmycin (57 ± 3, 56 ± 2, and 59 ± 1%, respectively) at the same dose. The antiviral mechanism study showed that compound 12 could cause 20S CP (coating protein) disk fusion and disintegration, thus affecting the assembly of virus particles. The result of molecular docking indicated that there were obvious hydrogen bonds between compound 12 and TMV CP. Most derivatives were active against larvae of lepidopteran pests, such as Mythimna separata, Pyrausta nubilalis, and Plutella xylostella. Some compounds also exhibited larvicidal activities against Culex pipiens; among them compounds 9 and 13 exhibited larvicidal activities of 0.81 and 1.54 mg/L (LC50), respectively. Moreover, most of the derivatives showed broad-spectrum fungicidal activities against 14 kinds of phytopathogenic fungi at 50 mg/L.

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Section: ■ Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%