Evaluation of the Relationship between Serum Lipid Profile andOral Lichen Planus

Abstract

Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. Here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases.Materials and methods. The present cross-sectional study evaluated 88 patients referring to the Department of Oral Medicine in 3 groups (Group 1: erosive OLP; Group 2: non-erosive OLP; Group 3: healthy). A total of 3 mL of blood sample was taken from each subject and the serum levels of cholesterol, triglycerides, HDL and LDL were determined. The mean outcomes of each group were compared with each other and analyzed two by two.Results. The results of statistical analyses showed no significant differences in mean HDL and LDL serum levels between the three groups. The results of post hoc LSD test showed that mean serum levels of subjects with erosive and non-erosive lichen planus were higher than those in healthy subjects. In relation to triglyceride serum levels, the mean serum levels of triglycerides were higher in erosive and non-erosive OLP patients compared to healthy subjects.Conclusion. Triglyceride and cholesterol can be considered to have a critical role in the incidence of lichen planus and in its manifestations as predisposing factors.

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

“…When compared to the control group they found a significant relation between oral LP with triglycerides levels and low HDLC levels (p value of 0.00 and 0.02 respectively). 19 Study done by Sarkar et al could also demonstrate similar results in a case control study done among 25 LP patients and age and gender matched controls. Along with altered HDLC and triglyceride levels, they found that the levels of LDL was also high among LP patients.…”

“…18 Similarly by Mehdipour in their study reported increased prevalence of LP among patients of age group 40 to 60 yrs. 19 Among the patients with metabolic syndrome, maximum number of LP patients belonged to the sixth decade which was 7 (38.88%) of the 18 patients. While among the control group, maximum individuals with metabolic syndrome belonged to fifth and sixth decade which was 9 (28.12%) each in both decades.…”

Comparative evaluation of prevalence and phenotypic variations of Candida species in patients of oral lichen planus and oral lichenoid lesions with healthy individuals - A prospective microbiological study

“…Several studies were done by Mehdipour et al . [ 11 ] and Ebrahimi et al . [ 12 ] show variable results in OLP and control group.…”

“…[ 6 ] Besides Candida albicans , Non- C. albicans strains, such as Candida parapsilosis , Candida tropicalis , C. dubliniensis , Candida krusei and Candida glabrata , are frequently detected in OLP and OLL. [ 6 7 8 9 10 11 12 13 ] Various studies are done which have shown that there is a differing capability of various strains to promote dysplasia by catalyzing the production of nitrosamine (carcinogenic) and also because of metabolism of ethanol to the carcinogenic acetaldehyde and induction of proinflammatory cytokines. [ 14 ] As there is a differing pathogenic potential of various Candida species, identification of species may play a pivotal role in successful clinical management.…”

Alterations of serum lipid profile patterns in oral lichen planus patients: A case–control study

“…The final consequence is an increased accumulation of cholesterol in cells. [ 10 ] When the compensatory response (inflammation) is not able to repair injury, it turns into a harmful reaction, and the lipid changes will become chronic, either by repeated or overwhelming stimulus, enhancing the formation of atherosclerotic lesions. Thus, the classical lipid changes associated may be envisioned as a highly conserved evolutionary response aimed at tissue repair.…”