Evaluation of the relationship between subclinical hypothyroidism and metabolic syndrome components among workers

Cheserek, Maureen Jepkorir; Wu, Guangdong; Shen, Liye; Shi, Yonghui; Li, Guowei

doi:10.2478/s13382-014-0240-5

Cited by 18 publications

(14 citation statements)

References 42 publications

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“…22 This study shows the significant difference in lipid parameters between cases and controls group. Elevated serum concentrations of TC, TG and LDL-cholesterol in SCH patients were supported by MJ Cheserek et al study who reported that subclinical hypothyroidism was associated with metabolic syndrome components in males, not in females 23 while the higher concentration of HDL-cholesterol in the control group is supported by Erdum YT et al 24 Clinical and epidemiological studies have found that for the effectiveness of lowering the lipid concentration the ratio between LDL-cholesterol to HDL-cholesterol is an excellent marker. It was concluded that this LDL-cholesterol/HDL-cholesterol ratio describe the two-way route of cholesterol entering and exiting the arterial intima.…”

Section: Methodssupporting

confidence: 55%

“…18 Significant differences in this cross-sectional study, between SCH male patients and control group, supported the hypothesis that SCH patients are associated with metabolic syndrome components in males. 19 Madathil A et al observed that fatigue and another impaired functional status was associated with SCH males. 20 There was increased BMI in SCH males compared to control group.…”

Section: Methodsmentioning

confidence: 99%

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Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6

Gupta¹,

Sharma²,

Kumar³

et al. 2018

JCDR

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Background: Subclinical hypothyroidism causes development of cardiovascular risk is not very well defined due to contra dictory findings over the years. Role of inflammatory markers in Subclinical hypothyroidism is not very well studied in the past. Objective: The main objective of this study was to assessment of the role of interleukin-6 and C reactive protein in subclinical hypothyroidism patients having TSH <10µIU/ml. Material and Method: Total 90 young adult males from 20-40 years age group were recruited for the study in which 60 males were with recently diagnosed subclinical hypothyroidism and remaining 30 males were healthy controls. Subclinical hypothyroidism was diagnosed by measuring TSH and FT4, which were estimated by enzyme linked immunosorbent assay (ELISA). Total cholesterol, triglycerides, and High Density Lipoprotein-cholesterol were estimated by spectrophotometric method. Friedewald formula was used for the estimation of Low Density Lipoprotein cholesterol. Lipoprotein ratios (total cholesterol/HDL-cholesterol and LDL-Cholesterol/ HDL-cholesterol) were also estimated. C reactive protein and interleukin-6 were also estimated by ELISA. Results: Significant results were obtained among the various parameters between the groups. Thyroid stimulating hormone was significantly (<0.001) different between patients and control group. In subclinical hypothyroidism patients total cholesterol, triglycerides and LDL cholesterol were significantly higher (<0.01). HDL cholesterol was significantly (<0.001) lower in the patient group. Lipoprotein ratios were also highly significant (<0.001) between the groups and concentrations were higher in the patient group. C reactive protein and interleukin-6 were highly significant (<0.001) between the groups. Conclusion: Subclinical hypothyroidism patients having TSH<10µIU/ml are characterized by the atherogenic lipid profile. Increased concentration of interleukin-6 along with higher concentration of C reactive protein might be the sign of early risk of atherogenic risk progression.

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Section: Methodssupporting

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6

Gupta¹,

Sharma²,

Kumar³

et al. 2018

JCDR

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“…The study participants were university employees on routine annual clinical examination at the Jiangnan University hospital. In our previous work ( 24 ), we found high prevalence of metabolic syndrome and its components among male workers compared to females (n=2428) that was attributed to occupation type and SCH ( 25 ). In the present study, we further examined whether there was increased oxidative stress in randomly selected males (35–59 years) with SCH (n=467) compared with individuals with normal thyroid function (n=190).…”

Section: Methodsmentioning

confidence: 77%

Association Between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical Hypothyroidism / Povezanost Izme\U Tireoidnih Hormona, Lipida I Markera Oksidativnog Stresa U SubkliniĉKoj Hipotireozi

Cheserek¹,

Wu²,

Ntazinda³

et al. 2015

Journal of Medical Biochemistry

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SummaryBackgroundOxidative stress plays a role in the pathogenesis of many chronic diseases. It is recognized in overt hypothyroidism while its existence in subclinical hypothyroidism (SCH) is not well established. The aim of this study was to determine whether there was increased oxidation of lipids and proteins in SCH, and examine their association with lipids and thyroid hormones.MethodsMale adults (35–59 years) with SCH (n=467) and euthyroid controls (n=190) were studied. Anthropometric measurements, plasma lipids, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total antioxidant capacity (T-AOC), lipid peroxidation products, malondialdehyde (MDA), advanced oxidation protein products (AOPP) and dityrosine concentrations were measured.ResultsPlasma concentrations of MDA were significantly higher (p<0.05) in SCH (8.11±1.39 nmol/mL) compared with euthyroid controls (7.34±1.31 nmol/mL) while AOPP, dityrosine and T-AOC levels were not different. MDA was not associated with TSH (β=−0.019, P=0.759), FT4 (β=−0.062, P=0.323) and FT3 (β=−0.018, P=0.780) in SCH while levels increased with elevated total cholesterol (β=0.229, P=0.001), LDL (β=0.203, P=0.009) and triglycerides (β=0.159, P=0.036) after adjustment for age and body mass index. T-AOC reduced (β=−0.327, P=0.030) with increased MDA in euthyroid controls and not in SCH (β=−0.068, P=0.349), while levels increased with elevated triglycerides in both groups.ConclusionsOxidative stress was increased in subclinical hypothyroidism as evidenced by the elevated lipid peroxidation product, malondialdehyde, while protein oxidation was absent. Thus, reduction of oxidative stress may be beneficial in patients with subclinical hypothyroidism.

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“…Hadaegh et al [16] found that female gender had lower risk for incident of MetS than male [HR: 0.58 (0.47-0.70)]. Also, Cheserek et al [22] showed that subclinical hypothyroidism was associated with metabolic syndrome components in males but not in females.…”

Section: Prace Oryginalnementioning

confidence: 98%

Niedoczynność tarczycy u pacjentów z zespołem metabolicznym

Gierach

Junik

2015

Endokrynologia Polska

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Introduction: Metabolic syndrome involves abdominal obesity, arterial hypertension, type 2 diabetes and lipid disorders manifested as atherogenic dyslipidaemia. Abnormal thyroid function affects the severity of MetS components, since regulating metabolism is one of the most important functions of thyroid hormones. In this study, we present the influence of hypothyroidism on lipid and carbohydrate disorders in patients with MetS. Material and methods: The described study was a prospective, two-centre screening study of 24-month duration. The study participants were 441 patients (350 women, 91 men, aged 28-82) with metabolic syndrome diagnosed according to the 2005 IDF. Results: By comparing the study and the control group, statistically significant differences were observed in the mean triglyceride levels (respectively 161,5 vs. 134,8 mg/dL, p = 0.047), mean fasting glycaemia (respectively 111,8 vs. 126,1 mg/dL, p = 0.044) and TG/HDL ratio (4,74 vs. 3,71, p = 0.043). Hypothyroidism shows a positive correlation with the TG levels and TG/HDL-C ratio and a negative correlation with the mean fasting glycaemia in people with MetS. A significantly higher TG/HDL-C ratio and lower mean insulin sensitivity ratio observed in men with hypothyroidism, indicated higher insulin resistance in men. Conclusions: In view of the above, it may be hypothesized that in patients with both MetS and hypothyroidism, especially of male gender, the risk of death of cardiovascular causes is greater due to the severity of MetS components. Moreover, we suggest that in patients recently diagnosed with MetS, active detection of hypothyroidism should be performed by determining the TSH levels, while patients diagnosed with hypothyroidism (apart from replacement therapy) should be monitored for the possible occurrence of MetS in the future.

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Evaluation of the relationship between subclinical hypothyroidism and metabolic syndrome components among workers

Cited by 18 publications

References 42 publications

Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6

Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6

Association Between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical Hypothyroidism / Povezanost Izme\U Tireoidnih Hormona, Lipida I Markera Oksidativnog Stresa U SubkliniĉKoj Hipotireozi

Niedoczynność tarczycy u pacjentów z zespołem metabolicznym

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