Evaluation of the Relationship of Intracranial Pressure with the Levels of Hypothalamic-Pituitary-Gonadal Axis Hormones on Prognosis in Severe Brain Injury

Abstract

Anah tar Ke li me ler Öz AbstractObjective: Head traumas have an important place among all traumatic injuries and it is an important public health problem worldwide. Novel methods predicting prognosis may contribute to a decrease in the mortality and morbidity rates. Materials and Methods: Continuous intracranial pressure (ICP) measurements, initial cerebral computed tomography (CT) and measurement of the hypothalamicpituitary-gonadal (HPG) axis hormones between the 0 th and 4 th days were performed in 15 adult male patients with severe head trauma. The relationship of these parameters with the short-term results of the patients on the 15 th day was evaluated. Additionally, provocation tests were carried out to evaluate the HPG axis function. Results: High ICP and compression of basal cisterna increased mortality and they were found to affect prognosis (p=0.009 and p=0.033, respectively) No statistically significant association was found between midline shift and prognosis. No relationship was found between mortality and mean basal hormone values on the 0 th day and between the 1 st and 4 th days. Conclusion:ICP measurement values and the presence of compression of basal cistern on the initial brain CT can be used to predict the prognosis in severe head injury but there is no significant relationship between hypophyseal hormone values and prognosis.Amaç: Kafa travmaları tüm travmatik yaralanmalar içinde önemli bir yer tutar ve ülkeler için önemli bir sağlık problemidir. Prognozu tahmin edici öngören yöntemlerin artması mortalite ve morbidite oranlarının azalmasını sağlayabilir. Gereç ve Yöntemler: Çalışmada 15 ağır kafa travmalı yetişkin erkek olguda sürekli intrakraniyal basınç (İKB) ölçümleri, ilk bilgisayarlı beyin tomografisi (BT), 0-4. günlerde büyüme hormonu, tiroid uyarıcı hormon, lüteinleştirici hormon, folikül uyarıcı hormon, prolaktin T3, T4 ve Te hormon düzeyleri ölçümü yapıldı. Bu