Evaluation of the Reproducibility of Nasal Allergen Challenge in Mild Allergic Asthmatics to Support Drug Development

Management of childhood asthma and tools to evaluate asthma pathophysiology

“…This issue's second editor's choice article evaluates the suitability of nasal allergen challenge (NAC) for small proof of mechanism studies in early clinical development by assessing reproducibility of nasal symptoms and biomarkers of the early-and late-phase allergy response at baseline and after NAC in participants with mild atopic asthma. 4 NAC is often used as a surrogate for bronchial provocation in research and clinical settings for several reasons. 5 Bronchial provocation, which involves inhaling allergens, can be more invasive and potentially riskier than nasal challenges.…”

“…This issue's second editor's choice article evaluates the suitability of nasal allergen challenge (NAC) for small proof of mechanism studies in early clinical development by assessing reproducibility of nasal symptoms and biomarkers of the early‐ and late‐phase allergy response at baseline and after NAC in participants with mild atopic asthma 4 …”

“…To simulate a clinical trial with a novel therapeutic, biomarkers and symptoms were compared in a subset of participants who underwent pre‐treatment with intranasal corticosteroids (INCS) or placebo prior to NAC. Bauer et al 4 . have shown that NAC‐induces reproducible nasal symptoms and biomarkers induction reflecting early‐ and late‐phase allergy response.…”